Taenia crassiceps:in vivoandin vitromodels

Abstract

Taenia crassiceps is a cestode parasite of wild and domestic animals that rarely affects humans; it has been widely used as an experimental model. The asexual proliferation by budding is a useful attribute of T. crassiceps cysticerci, which allows the various strains to be maintained indefinitely in the peritoneal cavity of inbred mice. Over the last 50 years, experimental results using larval and adult stages of T. crassiceps have yielded much information on the morphology, infectivity, proliferation dynamics, host immune response, endocrinological responses and vaccine research, all of which have contributed to our knowledge of cestode biology.

Murine cysticercosis model: Influence of the infection time and the time of treatment on the cysticidal efficacy of albendazole and praziquantel

“…Also, animal experimentation is an important tool to determine the effectiveness of new drugs in development, including its efficacy and security. Although different strains of T. crassiceps have been used as an alternative model to T. solium for the study of topics such as immunology, genetic, and metabolic pathways (Willms and Zurabian, 2010), only the ORF and WFU strains have been used for the in vivo evaluation of the efficacy of androgens (proposed as anti-parasitic molecules) (Carrero et al, 2010), cysticidal drugs (Zurabian et al, 2013) and new formulations of ABZ (Palomares-Alonso et al, 2010).…”

“…There are some drawbacks to the use of these models, such as the complexity to get infected animals, the difficulty to reproduce the infection in experimental conditions and the high cost of the studies. Taking into account these issues, T. crassiceps cysts, which exhibit extensive antigen similarities with T. solium, have been used as an alternative model for cestode infections (Stringer et al, 2003;Willms and Zurabian, 2010). Additionally, the infection by T. crassiceps is easily attained by its intraperitoneal injection in mice and can be maintained indefinitely by serial sub-inoculations (Freeman, 1962).…”

Sensitive In Vitro System To Assess Morphological and Biochemical Effects of Praziquantel and Albendazole on Taenia solium Cysts

“…Studies using T. solium cysts are difficult because many infected pigs are required, harvesting cysts individually is laborious and time-consuming, and culturing and maintaining cysts in the laboratory is difficult. For these reasons, cysts of a related parasite of the same genus as T. solium, Taenia crassiceps, have been commonly used instead of T. solium cysts for in vitro studies of drug effects and parasite biology (16,17,32). However, it is not known whether any or all of the conclusions from these studies can be applied to T. solium.…”

Cysticidal activity of extracts and isolated compounds from Teloxys graveolens: In vitro and in vivo studies

“…This metacestode has been used as an alternative model of T. solium for the study of topics as development of vaccines and metabolic pathways (Willms and Zurabian, 2010). Also it has been used to evaluate the in vitro and in vivo effect of androgens (proposed as anti-parasitic molecules) (Carrero et al, 2010) as well as the cysticidal activity of drugs and new formulations of ABZ (Palomares-Alonso et al, 2010;Zurabian et al, 2013).…”