[(tBu₂PhP)Ag(μ-OCF₃)]₂: A Thermally Stable, Light-Insensitive Nucleophilic Reagent for Trifluoromethoxylation

Silver(i) Perfluoroalcoholates: Synthesis, Structure, and their Use as Transfer Reagents

“…In recent years, the trifluoromethoxy group (À OCF 3 ) gained importance as a unique functional group in medicinal research, [1,2] materials science, [3] and coordination chemistry. [4][5][6][7] Particularly, trifluoromethoxylation is a useful tool to tune the lipophilicity and metabolic stability, and to influence the conformation of bioactive compounds. [2] Unlike other fluorinated groups, the À OCF 3 group has the advantage of being degradable into non-persistent compounds, like CO 2 and HF.…”

“…[24] M[OC(R F ) 2 F] species with the tendency to decompose can be stabilized by overcoming the lattice energy of MF by dissolution in a suitable solvent. [22] Alternatively, M[OCF 3 ] species like [(SIPr)M(OCF 3 )] (M = Cu or Au), [6] [Ag(bpy)(PPh t Bu 2 )(OCF 3 )], [4] [Ag(PPh t Bu 2 )(OCF 3 )] 2 , [7] or [Ag-(Aryl-BIAN)(THF)(OCF 3 )] [5] are stabilized by using, e. g., phosphines, NHC or bidentate nitrogen ligands. Therefore, we envisaged to prepare and investigate an array of silver(i) salts of perfluoroalkoxy groups that could be used as atom-economic reagents for the introduction of perfluoroalkoxy groups into organic and inorganic molecules.…”