SWELL1is a glucose sensor required for β-cell excitability and insulin secretion

Abstract

23Insulin secretion from the pancreatic β-cell is initiated by activation of voltage-gated Ca 2+ channels 24(VGCC) to trigger Ca 2+ -mediated insulin vesicle fusion with the β-cell plasma membrane. The firing of 25VGCC depends on the β-cell membrane potential, which is in turn mediated by the balance of 26 depolarizing (excitatory) and hyperpolarizing (inhibitory) ionic currents 1-3 . While much attention has 27 focused on inhibitory potassium currents 4-10 there is little knowledge about the excitatory currents 28 required to depolarize the β-cell, including the molecular identity of these excitatory currents 3 . Here we

Trends in volume-regulated anion channel (VRAC) research: visualization and bibliometric analysis from 2014 to 2022

“…This is partly because it not only transports inorganic anions but also organic osmolytes, such as taurine, amino acids, ATP, cGAMP, and xenobiotics like specific antibiotics, cytostatics, and dyes (Hyzinski-García et al, 2014;Lee et al, 2014;Qiu et al, 2014;Voss et al, 2014;Planells-Cases et al, 2015;Gaitán-Peñas et al, 2016;Lutter et al, 2017;Zhou C. et al, 2020;Lahey et al, 2020;Model et al, 2022). Several studies have highlighted the role of VRAC in glucose sensing and insulin signaling (Zhang et al, 2017;Kang et al, 2018;Stuhlmann et al, 2018), myoblast differentiation (Chen et al, 2019a;Chen et al, 2020;Kumar et al, 2020), sperm development (Lück et al, 2018), immune response through cGAMP signaling (Zhou C. et al, 2020;Lahey et al, 2020;Concepcion et al, 2022), NLRP3 activation (Daniels et al, 2016;Green et al, 2020), maintenance of vascular function (Alghanem et al, 2021), and tumor drug resistance (Planells-Cases et al, 2015;Sørensen et al, 2016). Moreover, VRAC has been associated with disease states including agammaglobulinemia (Sawada et al, 2003), male sterility (Bao et al, 2018), type 2 diabetes (Gunasekar et al, 2022), stroke (Yang et al, 2019b;, and diverse types of cancer (Zhang et al, 2018;Konishi et al, 2019;Lu et al, 2019;Kurashima et al, 2021).…”