I₂/TBHP mediated domino synthesis of 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-aryl/alkyl benzamides and evaluation of their anticancer and docking studies

Abstract

A novel I2/TBHP mediated domino reaction of isatins for the synthesis of 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-phenyl benzamides was described. The synthesized compounds gave promising results and were screened for cytotoxicity against cancerous cell lines.