I₂/DMSO mediated multicomponent reaction for the synthesis of 2-arylbenzo[d]imidazo[2,1-b] thiazole derivatives

Abstract

A series of 2-arylbenzo[d]imidazo[2,1-b] thiazoles tethered with barbituric acid has been prepared using I2 in DMSO medium under conventional or microwave heating conditions.

A Review on Molecular Iodine Catalyzed/Mediated Multicomponent Reactions

“…Many thiazole and thiazine derivatives have been synthesized, using molecular iodine as catalyst, from benzaldehydes or aryl methyl ketones under mild reaction conditions. A threecomponent reaction of aryl methyl ketones, 2-aminobenzothiazoles and barbituric acids catalyzed by iodine in DMSO for the synthesis of 2-arylbenzo[d]imidazo[2,1-b] thiazole derivatives 102 was given by Jana et al [102] (Scheme 52). Terminal aryl acetylenes in place of aryl methyl ketones also give the same product under similar reaction conditions.…”

α-Aminoazoles/azines: key reaction partners for multicomponent reactions

“…Consequently, a series of benzothiazole-fused imidazoles 139 and 140 was prepared in good yield ( Scheme 45 ). 115 …”

Iodine-Catalyzed Multicomponent Synthesis of Highly Fluorescent Pyrimidine-Linked Imidazopyridines

“… 12 The design and synthesis of hybrid molecules bearing more than one pharmacophore has gained considerable interest in recent times. 13 Considering the importance of hybrid molecules, imidazopyridines and the pyrimidine moiety, and in continuation of our work on the development of new methodologies, 14 we turned our attention to developing a new metal-free methodology for the synthesis of pyrimidine-linked imidazopyridines from the readily available starting materials. From the literature, we realized that the reaction of aryl methyl ketone and aminopyridine has been utilized for the preparation of diverse substituted imidazopyridine derivatives under different reaction conditions ( Scheme 1 ).…”