Streptomyces metabolites in divergent microbial interactions

Abstract

Streptomyces and related bacteria produce a wide variety of secondary metabolites. Of these, many compounds have industrial applications, but the question of why this group of microorganism produces such various kinds of biologically active substances has not yet been clearly answered. Here, we overview the results from our studies on the novel function and role of Streptomyces metabolites. The diverged action of negative and positive influences onto the physiology of various microorganisms infers the occurrence of complex microbial interactions due to the effect of small molecules produced by Streptomyces. The interactions may serve as a basis for the constitution of biological community.

The regulatory mechanism underlying light-inducible production of carotenoids in nonphototrophic bacteria

“…In addition, the mutation in cbl genes causes a defect in the morphological differentiation and in production of two pigment antibiotics in S. coelicolor, although the mutation mostly did not affect the viability in a rich culture medium. 34) The pleiotropic role of Cbl in the development of Streptomyces indicates that Cbl participates in primary metabolism and serves as a signaling compound involved in the signal transduction supporting the complex life cycle.…”

A putative redox‐sensing regulator Rex regulates lincomycin biosynthesis in Streptomyces lincolnensis

“…Streptomycetes are Gram-positive filamentous bacteria and are the main source for numerous secondary metabolites, which are used in medical and industrial applications, such as antibiotics, antifungals, antiparasitics, antitumor agents, or vitamins [1,2]. Lincomycin, which belongs to lincosamide antimicrobial agent, was isolated from Streptomyces lincolnensis in 1962 [3].…”

Impact of otrA expression on morphological differentiation, actinorhodin production, and resistance to aminoglycosides in Streptomyces coelicolor M145

“…Streptomyces species are Gram-positive soil bacteria known for their ability to produce a wide range of metabolites including clinically important antibiotics, biologically active compounds along with agents used in the agricultural, veterinary, and food industries (Chandra and Chater, 2014;Niu et al, 2016;Takano et al, 2016). Strain improvement is indispensable for the profitable commercialization of these natural products (Chen et al, 2010;Baltz, 2016).…”