<i>Streptococcus sanguis</i>Modulates Type II Collagen-Induced Arthritis in DBA/1J Mice

Costalonga, Massimo; Hodges, James S.; Herzberg, Mark C.

doi:10.4049/jimmunol.169.4.2189

Cited by 15 publications

(5 citation statements)

References 52 publications

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“…DBA/1J mice subjected to CIA display less-inflammatory changes when pups are fed shortly postpartum with Streptococcus sanguis (7). Infection of rats with the protozoan responsible for African sleeping sickness (Trypanosoma brucei) partially prevented the development of collagen arthritis (20).…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of an Extract fromAscaris suumin Experimental Arthritis Models

Rocha¹,

Leite²,

Pompeu

et al. 2008

Infect Immun

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We investigated the effect of an extract from a helminth (Ascaris suum) in zymosan-induced arthritis (ZYA) or collagen-induced arthritis (CIA). Rats and mice, respectively, received 1 mg and 0.1 mg zymosan intraarticularly (i.a.). Test groups received an A. suum extract either per os (p.o.) or intraperitoneally (i.p.) 30 min prior to i.a. zymosan. Controls received saline. Hypernociception was measured using the articular incapacitation test. Cell influx, nitrite, and cytokine levels were assessed in joint exudates. The synovia and distal femoral extremities were used for histopathology. Cartilage damage was assessed through determining glycosaminoglycan (GAG) content. DBA/1J mice were subjected to CIA. The test group received A. suum extract i.p. 1 day after CIA became clinically detectable. Clinical severity and hypernociception were assessed daily. Neutrophil influx was determined using myeloperoxidase activity. The A. suum extract, either i.p. or p.o., significantly and dose-dependently inhibited cell influx and hypernociception in ZYA in addition to reducing GAG loss and ameliorating synovitis. The A. suum extract reduced i.a. levels of NO, interleukin-1␤ (IL-1␤), and IL-10 but not tumor necrosis factor alpha (TNF-␣) in rats subjected to ZYA while reducing i.a. IL-10, but not IL-1␤ or TNF-␣, levels in mice. Clinically, mice subjected to CIA treated with the A. suum extract had less severe arthritis. Hypernociception, myeloperoxidase activity, and synovitis severity were significantly reduced. These data show that a helminth extract given p.o. protects from arthritis severity in two classical arthritis models. This A. suum effect is species independent and functions orally and parenterally. The results show clinical and structural benefits when A. suum extract is given either prophylactically or therapeutically.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of an Extract fromAscaris suumin Experimental Arthritis Models

Rocha¹,

Leite²,

Pompeu

et al. 2008

Infect Immun

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“…Reactivity to immunoglobulin isotypes other that IgG should also be considered. Therefore, breaking of tolerance to pig-serum antigens by C. hepatica infection, as suggested in other experimental systems (Costalonga et al 2002, Roep et al 2002, may still be the explanation for this finding. Yet, the raise in antibody levels to pig-serum antigens in previously unresponsive mice, induced by infection with C. hepatica in the absence of further specific antigen administration is intriguing, and suggests that the rats have been, in fact, silenced primed for an immune response.…”

Section: Discussionmentioning

confidence: 75%

Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats

Andrade

Gotardo

Assis

et al. 2004

Mem. Inst. Oswaldo Cruz

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“…Interestingly, the tolerogenic epitope of type II collagen (CII) is structurally mimicked by an epitope within the platelet aggregation-associated protein (PAAP) on Streptococcus sanguis. Feeding S. sanguis to DBA/1J pups delayed the onset of arthritis and reduced the rate, final severity, and percentage of affected limbs [17]. T cells primed with the tolerogenic epitope of CII proliferated more when incubated with PAAP(+) S. sanguis than with PAAP(−) S. gordonii or CII, suggesting an antigen-specific transmucosal tolerogenic effect.…”

Section: Experimental Models Of Protection By Infectionmentioning

confidence: 93%

Infections and Autoimmunity: A Panorama

Pordeus

Szyper‐Kravitz

Levy

et al. 2008

Clinic Rev Allerg Immunol

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For more than 2,000 years, it was thought that malignant spirits caused diseases. By the end of nineteenth century, these beliefs were displaced by more modern concepts of disease, namely, the formulation of the "germ theory," which asserted that bacteria or other microorganisms caused disease. With the emergence of chronic degenerative and of autoimmune diseases in the last century, the causative role of microorganisms has been intensely debated; however, no clear explanatory models have been achieved. In this review, we examine the current available literature regarding the relationships between infections and 16 autoimmune diseases. We critically analyzed clinical, serological, and molecular associations, and reviewed experimental models of induction of and, alternatively, protection from autoimmune diseases by infection. After reviewing several studies and reports, a clinical and experimental pattern emerges: Chronic and multiple infections with viruses, such as Epstein-Barr virus and cytomegalovirus, and bacteria, such as H. pylori, may, in susceptible individuals, play a role in the evolvement of autoimmune diseases. As the vast majority of infections pertain to our resident microbiota and endogenous retroviruses and healthy carriage of infections is the rule, we propose to focus on understanding the mechanisms of this healthy carrier state and what changes its configurations to infectious syndromes, to the restoration of health, or to the sustaining of illness into a chronic state and/or autoimmune disease. It seems that in the development of this healthy carriage state, the infection or colonization in early stages of ontogenesis with key microorganisms, also called 'old friends' (lactobacilli, bifidobacteria among others), are important for the healthy living and for the protection from infectious and autoimmune syndromes.

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Streptococcus sanguisModulates Type II Collagen-Induced Arthritis in DBA/1J Mice

Cited by 15 publications

References 52 publications

Protective Effect of an Extract fromAscaris suumin Experimental Arthritis Models

Protective Effect of an Extract fromAscaris suumin Experimental Arthritis Models

Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats

Infections and Autoimmunity: A Panorama

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