Streptococcus iniae in Gilthead Seabream (Sparus aurata, L.) and Red Porgy (Pagrus pagrus, L.)

Abstract

Streptococcosis caused by Streptococcus iniae has become one of the most serious marine and freshwater aquatic diseases in the past decade, causing large losses in farmed and wild fish worldwide. In this study, we performed an ultrastructural study of major lesions in gilthead seabream Sparus aurata and red porgy Pagrus pagrus experimentally infected with the S. iniae IUSA-1 strain, isolated in a natural outbreak in Spain in the mentioned species. The transmission electron micrographs revealed the resistance of this pathogen inside the phagosome, indicating that the macrophage may provide a significant bacterial reservoir for continuing infection, disease dissemination, and tissue injury by crossing the blood-brain barrier.

Interactions of Streptococcus iniae with phagocytic cell line

“…S. iniae is reportedly able to withstand the bactericidal activity of macrophages [35]. We have recently described the morphologique changes of S. iniae located in the nervous system of fish, expressing an extracellular microcapsule [36].…”

Complete Genome Sequence of a Virulent Strain, Streptococcus iniae ISET0901, Isolated from Diseased Tilapia

“…In aquaculture, S. iniae is a serious marine and freshwater fish pathogen causing significant economic losses (4, 5). Originally isolated from Amazon freshwater dolphin ( Inia geoffrensis ) in 1976 (6), S. iniae causes mortalities in >30 species of fish, including rainbow trout ( Oncorhynchus mykiss [7]), barramundi ( Lates calcarifer [8]), red drum ( Sciaenops ocellatus [9]), flounder ( Paralichthys spp.…”

Complete Genome Sequence of the Attenuated Novobiocin-Resistant Streptococcus iniae Vaccine Strain ISNO

“…As a serious marine and freshwater fish pathogen, S. iniae causes significant economic losses to aquaculture (4, 5). This pathogen was originally isolated from Amazon freshwater dolphin ( Inia geoffrensis ) in 1976 (6).…”