<i>Streptococcus constellatus</i> Causing Empyema and Sepsis, Necessitating Early Surgical Decortication

Chrastek, David; Hickman, Sarah; Sitaranjan, D; Vokshi, I; Kakisi, Ourania K.; Kadlec, Jakub; Bartosik, Waldemar; Tornout, Filip Van; Kouritas, Vasileios

doi:10.1155/2020/4630809

Cited by 10 publications

(11 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Generally, the prognosis of infection caused by SC is relatively less severe, sufficiently treated with simple drainage and intravenous antibiotics, had a shorter hospital stay, and lower than 30-day mortality rate compared to other SAG species. 2,12 Those reports were similar to the patient in this case which clinically and laboratory improved after being hospitalized for 10 days and was treated with water seal drainage and intravenous combined antibiotics. Clinically, the patient's symptoms such as difficulty in breathing, cough, and weakness were decreasing after 2 days and were resolved after 10 days of therapy.…”

Section: Introductionsupporting

confidence: 71%

See 1 more Smart Citation

Clinical Microbiology Perspective of Empyema caused by Streptococcus constellatus in Malignancy Patient: A Case Report

Sekar

Sarassari

Soedarsono

et al. 2021

View full text Add to dashboard Cite

Introduction: Streptococcus constellatus (SC) is commensal bacteria and belongs to Streptococcus anginosus group (SAG). However, SC causes infections especially in patient with underlying diseases. SC empyema is a clinical case that is described in very few studies, especially in Indonesia.Case: A 45-year-old man was admitted to emergency department in Dr. Soetomo General Hospital Surabaya with respiratory insufficiency on November 11th 2020 after 3 months of non-productive cough and a week of weakness. He was diagnosed with empyema on right hemithorax and received chest tube insertion. SC was isolated from pleural fluid sample after first day of culture on Bactec BD bottle. GeneXpert result of pleural fluid was negative for Mycobacterium tuberculosis (MTB). He completed 10 days of intravenous ampicillin-sulbactam and metronidazole. The CT scan reported solid mass of 4.7x7.4x7.8 cm in posterolateral segment of inferior lobe right lung, right pleural effusion, with adenocarcinoma as biopsy result.Discussion: SC is a normal commensal in respiratory tract, however with the presence of a certain factor such as immunocompromised, colonized SAG directly induces an infection after entering normal sterile sites in the body including pleural fluid.Conclusion: Although infection caused by SC is a rare case, it still should be considered in clinical diagnosis and treatment of related infections, particularly in patients with comorbidities. The prognosis was good with appropriate antibiotics and chest tube insertion.

show abstract

Section: Introductionsupporting

confidence: 71%

“…However, a report in the UK reported a patient with empyema caused by SC that required extensive decortication and prolonged hospital admission. 12 Therefore, the pathogenic potential of commensal bacteria such as SCshould not be underestimated especially in patients with immunocompromised.…”

Section: Introductionmentioning

confidence: 99%

Clinical Microbiology Perspective of Empyema caused by Streptococcus constellatus in Malignancy Patient: A Case Report

Sekar

Sarassari

Soedarsono

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The large anginosus group, which is also called the milleri group, includes two other important species in human pathology. Streptococcus constellatus and Streptococcus intermedius belong to the human microbiota and can be involved in severe invasive infections like bacteremia, endocarditis, or deep abscesses (Tran et al, 2008;Chrastek et al, 2020). Concerning the presence of CRISPR-Cas systems, two types can be found in S. intermedius, type II-A and type II-C, like in S. anginosus but they are less well studied (Ben Zakour et al, 2012).…”

Section: Other Membersmentioning

confidence: 99%

Distribution, Diversity and Roles of CRISPR-Cas Systems in Human and Animal Pathogenic Streptococci

et al. 2022

View full text Add to dashboard Cite

Streptococci form a wide group of bacteria and are involved in both human and animal pathologies. Among pathogenic isolates, differences have been highlighted especially concerning their adaptation and virulence profiles. CRISPR-Cas systems have been identified in bacteria and many streptococci harbor one or more systems, particularly subtypes I-C, II-A, and III-A. Since the demonstration that CRISPR-Cas act as an adaptive immune system in Streptococcus thermophilus, a lactic bacteria, the diversity and role of CRISPR-Cas were extended to many germs and functions were enlarged. Among those, the genome editing tool based on the properties of Cas endonucleases is used worldwide, and the recent attribution of the Nobel Prize illustrates the importance of this tool in the scientific world. Another application is CRISPR loci analysis, which allows to easily characterize isolates in order to understand the interactions of bacteria with their environment and visualize species evolution. In this review, we focused on the distribution, diversity and roles of CRISPR-Cas systems in the main pathogenic streptococci.

show abstract

“…Streptococcus constellatus was the most commonly cultivated pathogen in the DNI patients regardless of whether they had concurrent AE (16.66%) or DNI alone (17.32%) ( Table 3 ). This microorganism is a small catalase-negative coccus, which belongs to the Anginosus group, formerly known as Streptococcus milleri (along with Streptococcus anginosus and Streptococcus intermedius ) [ 24 ]. Streptococcus constellatus infection was reported to be more common in patients aged between 35 and 54 years than in other age groups [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting Patients with Concurrent Deep Neck Infection and Acute Epiglottitis

Wang

Chin

et al. 2021

Diagnostics

View full text Add to dashboard Cite

Deep neck infection (DNI) is a serious disease of deep neck spaces that can lead to morbidities and mortality. Acute epiglottitis (AE) is a severe infection of the epiglottis, which can lead to airway obstruction. However, there have been no studies of risk factors in patients with concurrent DNI and AE. This study was performed to investigate this issue. A total of 502 subjects with DNI were enrolled in the study between June 2016 and August 2021. Among these patients, 30 had concurrent DNI and AE. The relevant clinical variables were assessed. In a univariate analysis, involvement of the parapharyngeal space (OR = 21.50, 95% CI: 2.905–158.7, p < 0.001) and involvement of the submandibular space (OR = 2.064, 95% CI: 0.961–4.434, p < 0.001) were significant risk factors for concurrent DNI and AE. In a multivariate analysis, involvement of the parapharyngeal space (OR = 23.69, 95% CI: 3.187–175.4, p = 0.002) and involvement of the submandibular space (OR = 2.465, 95% CI: 1.131–5.375, p < 0.023) were independent risk factors for patients with concurrent DNI and AE. There were no differences in pathogens, therapeutic managements (tracheostomy, intubation, surgical drainage), or hospital staying period between the 30 patients with concurrent DNI and AE and the 472 patients with DNI alone (all p > 0.05). However, we believe it is significant that DNI and AE are concurrent because both DNI and AE potentially cause airway obstruction, and concurrence of these two diseases make airway protection more difficult. The infections in critical spaces may cause the coincidence of these two diseases. Involvement of the parapharyngeal space and involvement of the submandibular space were independent risk factors associated with concurrent DNI and AE. There were no differences in pathogens between the concurrent DNI and AE group and the DNI alone group.

show abstract

Streptococcus constellatus Causing Empyema and Sepsis, Necessitating Early Surgical Decortication

Cited by 10 publications

References 11 publications

Clinical Microbiology Perspective of Empyema caused by Streptococcus constellatus in Malignancy Patient: A Case Report

Clinical Microbiology Perspective of Empyema caused by Streptococcus constellatus in Malignancy Patient: A Case Report

Distribution, Diversity and Roles of CRISPR-Cas Systems in Human and Animal Pathogenic Streptococci

Factors Affecting Patients with Concurrent Deep Neck Infection and Acute Epiglottitis

Contact Info

Product

Resources

About