<i>Streptococcus anginosus</i> infection in oral cancer and its infection route

Sasaki, Masahiro; Yamaura, C.; Ohara‐Nemoto, Yuko; Tajika, Shihoko; Kodama, Yoshitoyo; Ohya, Toshihide; Harada, Renata Midori; Kimura, Shigenobu

doi:10.1111/j.1601-0825.2005.01051.x

Cited by 111 publications

(90 citation statements)

References 33 publications

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“…S. anginosus is an opportunistic pathogen and forms part of the normal flora in the human oral cavity, genitourinary tract, and gastrointestinal tract (3), and it is generally considered to have a relatively low pathogenic potential compared with other streptococci, in particular members of the pyogenic species group. However, S. anginosus is increasingly being recognized as being able to cause a wide range of purulent infections that commonly manifest as abscess formation, and its presence has also been detected in esophageal cancer (4)(5)(6)(7)(8)(9). Despite the increased awareness of the clinical importance of S. anginosus, the molecular basis of pathogenicity of this species has not been determined.…”

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confidence: 99%

Novel Twin Streptolysin S-Like Peptides Encoded in the sag Operon Homologue of Beta-Hemolytic Streptococcus anginosus

Tabata

Nakano

Ohkura

et al. 2013

Journal of Bacteriology

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dStreptococcus anginosus is a member of the anginosus group streptococci, which form part of the normal human oral flora. In contrast to the pyogenic group streptococci, our knowledge of the virulence factors of the anginosus group streptococci, including S. anginosus, is not sufficient to allow a clear understanding of the basis of their pathogenicity. Generally, hemolysins are thought to be important virulence factors in streptococcal infections. In the present study, a sag operon homologue was shown to be responsible for beta-hemolysis in S. anginosus strains by random gene knockout. Interestingly, contrary to pyogenic group streptococci, beta-hemolytic S. anginosus was shown to have two tandem sagA homologues, encoding streptolysin S (SLS)-like peptides, in the sag operon homologue. Gene deletion and complementation experiments revealed that both genes were functional, and these SLS-like peptides were essential for beta-hemolysis in beta-hemolytic S. anginosus. Furthermore, the amino acid sequence of these SLS-like peptides differed from that of the typical SLS of S. pyogenes, especially in their propeptide domain, and an amino acid residue indicated to be important for the cytolytic activity of SLS in S. pyogenes was deleted in both S. anginosus homologues. These data suggest that SLS-like peptides encoded by two sagA homologues in beta-hemolytic S. anginosus may be potential virulence factors with a different structure essential for hemolytic activity and/or the maturation process compared to the typical SLS present in pyogenic group streptococci.

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mentioning

confidence: 99%

Novel Twin Streptolysin S-Like Peptides Encoded in the sag Operon Homologue of Beta-Hemolytic Streptococcus anginosus

Tabata

Nakano

Ohkura

et al. 2013

Journal of Bacteriology

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“…Infecção por Candida tem sido associada com desenvolvimento de câncer na cavidade bucal desde que foi encontrada como causa de leucoplasia bucal e correlacionada com displasia bucal epitelial 8 . Tem-se sugerido que o biofilme dental poderia atuar como um reservatório de S. anginosus que parece frequentemente infectar carcinomas bucais e esofágicos 42 . A sugestão de que bactérias bucais podem passar por meio do tecido mucoso para dentro de uma massa tumoral não é surpreendente; bactérias originadas da boca têm previamente sido apresentadas, infectando sistemicamente e podem translocar para dentro de linfonodos 43 .…”

Section: Discussionunclassified

Biofilmes Orais como Um Possível Fator de Risco ao Câncer Bucal

Ciesielski¹,

Biasoli²,

Goiato³

et al. 2010

Odonto

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127Biofilmes orais como um possível fator de risco ao câncer bucal Oral biofilms as a possible risk factor for oral cancerResumo Introdução: muito se estuda a respeito dos fatores de risco associados ao câncer bucal. Fatores como fumo, álcool e radiação solar já estão bem estabelecidos, porém outros, como a influência bacteriana no desenvolvimento ou progressão de uma neoplasia ainda permanecem inexplicados. O interesse na possibilidade de relação entre bactérias e diferentes estágios do desenvolvimento do câncer aumentou desde a classificação do Helicobacter pylori pela OMS como um carcinógeno definitivo. Subsequentemente, ligações entre infecções e o início de câncer em vários sítios do corpo foram descobertos.Revisão de literatura: esta revisão de literatura buscou demonstrar a influência da má higiene bucal, com consequente acúmulo bacteriano como um possível fator de risco importante ao início e desenvolvimento de neoplasias bucais, bem como correlacionar os possíveis mecanismos pelos quais as bactérias podem iniciar ou promover carcinogênese.Conclusões: existem muitas evidências de que bactérias presentes da cavidade bucal e periodontopatogênicas encontram-se presentes em tecidos neoplásicos, porém, ainda não se pode afirmar que tais bactérias iniciem ou promovam carcinogênese. Palavras-chave:Microbiologia; Câncer Bucal; Biofilme Dentário. AbstRACtIntroduction: much studies regarding risk factors associated with oral cancer. Factors such as smoking and alcohol and solar radiation are well established, but others, such as bacterial influence in the development or progression of a tumor still remain unexplained. Interest in the possible relationship between bacteria and different stages of cancer development has increased since the classification of H. pylori by the WHO as a definite carcinogen. Subsequently, links between infection and the onset of cancer in various sites in the body were discovered.Review of literature: this literature review attempts to show the influence of poor oral hygiene, with consequent bacterial accumulation as a possible important risk factor for the initiation and development of mouth cancer, and correlate the possible mechanisms by which bacteria can initiate or promote carcinogenesis. Conclusion:there is much evidence that bacteria in the oral cavity and periodontopathic are present in tumor tissue, however, still can not affirm that these bacteria initiate or promote carcinogenesis.

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“…S. anginosus ex ists only in dental plaques and cannot be detected in saliva. Sasaki et al [19] discovered high incidence of bacterial infection in patients with oral squamous cell carcinoma, and patients with S. anginosus detected in canceration position were also diagnosed with oral squamous cell carcinoma, which showed the same genotype of S. anginosus in squamous cell carcinoma region similar to that in dental plaques.…”

Section: Relationship Between Oral Microorganisms and Oral Squamous Cmentioning

confidence: 99%

“…Sasaki et al [19] observed that oral Streptococcus infection can induce synthesis of nitric oxide and cyclooxygenase-2, increase DNA damage, and promote occurrence of oral cancer. Some bacterial toxins can also interfere with signal transduction of cells and promote occurrence of tumors.…”

Section: N F L U E Nc E O F O R a L M Ic R O O R G A N I S M S A Ndmentioning

confidence: 99%

Research Progress on the Relationship Between Oral Microbial Community and Tumor

Ma¹

2016

Infection International

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Significant progress was observed in studies of the relationship between oral Helicobacter pylori and gastric cancer and tumors. Based on three distinct and close relationships, namely, the relationship between oral H. pylori and gastric cancer, between oral microbial communities and oral squamous cell carcinoma, and between oral microbial communities of human immunodeficiency virus-infected patients and tumors, this work reviews the relationship between oral microbial communities and tumors. This research also provides reference for further analysis of the relationship between oral microorganisms and tumors to realize early diagnosis of tumor patients through detecting oral microorganisms under adjuvant therapy.

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Streptococcus anginosus infection in oral cancer and its infection route

Abstract: Infection of S. anginosus could occur frequently in oral squamous cell carcinoma and that dental plaque could be a dominant reservoir of the S. anginosus.

Cited by 111 publications

References 33 publications

Novel Twin Streptolysin S-Like Peptides Encoded in the sag Operon Homologue of Beta-Hemolytic Streptococcus anginosus

Novel Twin Streptolysin S-Like Peptides Encoded in the sag Operon Homologue of Beta-Hemolytic Streptococcus anginosus

Biofilmes Orais como Um Possível Fator de Risco ao Câncer Bucal

Research Progress on the Relationship Between Oral Microbial Community and Tumor

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