<i>Stenotrophomonas maltophilia</i>: an emerging multidrug-resistant opportunistic pathogen in the immunocompromised host

Baumrin, Emily; Piette, Evan W.; Micheletti, Robert G.

doi:10.1136/bcr-2017-221053

Cited by 14 publications

(19 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, some microbial markers in HNSCC patients which positively correlated with HPB-releasing adduct levels, have been previously characterized as pathogenic, xenobiotic degrader and/or multidrug resistant taxa. For instance, Stenotrophomonas is reported to be a nosocomial pathogen, particularly associated with immunosuppressed individuals, and resistance to a broad range of antibiotics [37][38][39]. This observation is in line with our findings of increased abundance of predicted polymyxin resistance in cases, correlated with abundances of this taxon.…”

Section: Discussionsupporting

confidence: 90%

Oral Microbiome Profiling in Smokers with and without Head and Neck Cancer Reveals Variations Between Health and Disease

Sharma

DeBusk

Stepanov

et al. 2020

Cancer Prevention Research

View full text Add to dashboard Cite

While smoking is inextricably linked to Oral/Head and Neck Cancer (HNSCC), only a small fraction of smokers develop HNSCC. Thus, we have sought to identify other factors which may influence the development of HNSCC in smokers including microbiology. To determine microbial associations with HNSCC among tobacco users, we characterized oral microbiome composition in smokers with and without HNSCC. 16S rRNA MiSeq sequencing was used to examine the oral mucosa microbiome of 27 smokers with (cases) and 24 without HNSCC (controls). In addition, we correlated previously reported levels of DNA damage with the microbiome data. Smokers with HNSCC showed lower microbiome richness compared to controls (p=0.012). Beta-diversity analyses assessed as UniFrac (weighted and unweighted) and Bray-Curtis distances, showed significant differences in oral mucosal microbiome signatures between cases and controls (r2=0.03, p=0.03) and higher inter-individual microbiome heterogeneity in the former (q<=0.01). Higher relative abundance of Stenotrophomonas and Comamonadaceae and predicted bacterial pathways mainly involved in xenobiotic and amine degradation were found in cases compared to controls. The latter, in contrast, exhibited higher abundance of common oral commensals and predicted sugar degradation pathways. Lastly, levels of DNA damage in the oral cavity were correlated with the microbiome profiles above. Oral microbiome traits differ in smokers with and without HNSCC, potentially informing the risk of eventual HNSCC and shedding light into possible microbially-mediated mechanisms of disease. These findings present data which may be useful in screening efforts for HNSCC among smokers who are unable to quit.

show abstract

Section: Discussionsupporting

confidence: 90%

Oral Microbiome Profiling in Smokers with and without Head and Neck Cancer Reveals Variations Between Health and Disease

Sharma

DeBusk

Stepanov

et al. 2020

Cancer Prevention Research

View full text Add to dashboard Cite

show abstract

“…According to the collected data, the cells which were transformed by the plasmids of multi-drug resistant strain P. aeruginosa 5249, containing blaOXA10 βlactamase gene blaOXA10, pCAT639 and ATP-dependent aminoglycoside Оphosphotransferase gene aph (3') VI, were sensitive to Stp and Cam. It is caused by the plasmid localization of genes blaOXA10 and aph (3') VI and chromosomal localization of pCAT639 [30,31].…”

Section: Discussionmentioning

confidence: 99%

The Plasmid Differences in Multi-Drug Resistant Opportunistic Pathogenic Soil Strains of Pseudomonas and Stenotrophomonas

Babayan

2021

European Journal of Natural Sciences and Medicine

View full text Add to dashboard Cite

The antibiotic resistance and especially mult-idrug resistance is one of the most important factors for any microorganism survival in nature. In a majority of cases the resistance to antibiotics, as a property is being defined by several genes which are localized in plasmids, transposons and in other mobile genetical elements. As a result, it has been found out that in some native opportunistic pathogenic soil strains of Pseudomonas and Stenotrophomonas, the resistance to different antibiotics is caused by simultaneous presence of different plasmids in cells. Besides, the genes of resistance to various classes of antibiotics of I, II, III generations. They can be localized on one plasmid or in more than one plasmids of current bacterial cell. These plasmids of researched strains of Pseudomonas and Stenotrophomonas are able to stabile replication not only in cells permanently contacting with compatible antibiotic molecules in environment, but also in case of long-term cultivation of bacteria on synthetic media without any antibiotic. The antibiotic resistance of researched Pseudomonas and Stenotrophomonas strains, which is caused by mobile genetical elements, can be transferred among the microorganisms both in frames of one species and in interspecific and intergeneric gene transfer processes. The plasmids with the presence of genes of resistance to different antibiotics can be transferred to different microorganisms independently, with the forming of new resistant strains, which are differing in resistance to natural antimicrobial organic acidcs as well as their synthetic derivatives and it has a significant ecological and medical importance.

show abstract

“…Stenotrophomonas maltophilia is a non-fermentative Gram-negative bacillus that can be transmitted by nosocomial sources including contaminated disinfectants, intravenous fluids, hospital water, catheters, central venous and arterial pressure monitors, dialysis equipment, blood gas analyzers, ventilation circuits, thermometers, and intra-aortic balloon pumps [ 1 , 2 ]. Although S. maltophilia is known to colonize the skin, gastrointestinal tract, and respiratory tract, S. maltophilia can cause opportunistic infections, including bacteremia, pulmonary infections, urinary tract infections, and skin and soft tissue infections (SSTI), in immunocompromised hosts [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Stenotrophomonas maltophilia, a Pathogen of Increasing Relevance to Dermatologists: A Case Report and Review of the Literature

et al. 2022

View full text Add to dashboard Cite

Stenotrophomonas maltophilia is a Gram-negative bacillus that causes skin and soft tissue infections (SSTI), as well as bacteremia, pneumonia, and urinary tract infections. S. maltophilia infections are typically nosocomial and are often transmitted through water sources. Although historically described in immunocompromised hosts, S. maltophilia prevalence is increasing in both immunocompromised and immunocompetent populations. In light of high morbidity and mortality, it is critical that dermatologists are aware of this organism because of the limited options for therapy. Here, we describe a case of a S. maltophilia abscess with bacteremia in a patient with chronic lymphocytic leukemia and aplastic anemia that was successfully treated with trimethoprim–sulfamethoxazole. We also review the current standard of care and propose an algorithm for the treatment of S. maltophilia infection.

show abstract

Stenotrophomonas maltophilia: an emerging multidrug-resistant opportunistic pathogen in the immunocompromised host

Cited by 14 publications

References 9 publications

Oral Microbiome Profiling in Smokers with and without Head and Neck Cancer Reveals Variations Between Health and Disease

Oral Microbiome Profiling in Smokers with and without Head and Neck Cancer Reveals Variations Between Health and Disease

The Plasmid Differences in Multi-Drug Resistant Opportunistic Pathogenic Soil Strains of Pseudomonas and Stenotrophomonas

Stenotrophomonas maltophilia, a Pathogen of Increasing Relevance to Dermatologists: A Case Report and Review of the Literature

Contact Info

Product

Resources

About