<i>Staphylococcus saprophyticus</i>surface-associated protein (Ssp) is associated with lifespan reduction in<i>Caenorhabditis elegans</i>

Szabados, Florian; Mohner, Amelie; Kleine, Britta; Gatermann, Sören

doi:10.4161/viru.25875

Cited by 11 publications

(10 citation statements)

References 30 publications

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“…Extracellular enzymes such as the Streptococcal Surface Enolase (SE) and glyceradehyde-3-phosphate degydrogenase (GAPDH) have evolved to also function as adhesins in some pathogens (Li et al, 2015). The McaP of Moraxella catarrhalis is a lipase/adhesin (Timpe et al, 2003); the Ssp of Staphylococcus saprophytycus is a surface-associated lipase that contributes to virulence (Sakinc et al, 2005, Szabados et al, 2013). The Als family of adhesins in Candida albicans are multifunctional family of proteins (Hoyer and Cota, 2016).…”

Section: Establishment Of Other Bacterial Infectionsmentioning

confidence: 99%

Mycobacterium tuberculosis Primary Infection and Dissemination: A Critical Role for Alveolar Epithelial Cells

Ryndak

Laal

2019

Front. Cell. Infect. Microbiol.

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Globally, tuberculosis (TB) has reemerged as a major cause of morbidity and mortality, despite the use of the Mycobacterium bovis BCG vaccine and intensive attempts to improve upon BCG or develop new vaccines. Two lacunae in our understanding of the Mycobacterium tuberculosis ( M. tb )-host pathogenesis have mitigated the vaccine efforts; the bacterial-host interaction that enables successful establishment of primary infection and the correlates of protection against TB. The vast majority of vaccine efforts are based on the premise that cell-mediated immunity (CMI) is the predominating mode of protection against TB. However, studies in animal models and in humans demonstrate that post-infection, a period of several weeks precedes the initiation of CMI during which the few inhaled bacteria replicate dramatically and disseminate systemically. The “Trojan Horse” mechanism, wherein M. tb is phagocytosed and transported across the alveolar barrier by infected alveolar macrophages has been long postulated as the sole, primary M. tb :host interaction. In the current review, we present evidence from our studies of transcriptional profiles of M. tb in sputum as it emerges from infectious patients where the bacteria are in a quiescent state, to its adaptations in alveolar epithelial cells where the bacteria transform to a highly replicative and invasive phenotype, to its maintenance of the invasive phenotype in whole blood to the downregulation of invasiveness upon infection of epithelial cells at an extrapulmonary site. Evidence for this alternative mode of infection and dissemination during primary infection is supported by in vivo, in vitro cell-based, and transcriptional studies from multiple investigators in recent years. The proposed alternative mechanism of primary infection and dissemination across the alveolar barrier parallels our understanding of infection and dissemination of other Gram-positive pathogens across their relevant mucosal barriers in that barrier-specific adhesins, toxins, and enzymes synergize to facilitate systemic establishment of infection prior to the emergence of CMI. Further exploration of this M. tb :non-phagocytic cell interaction can provide alternative approaches to vaccine design to prevent infection with M. tb and not only decrease clinical disease but also decrease the overwhelming reservoir of latent TB infection.

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Section: Establishment Of Other Bacterial Infectionsmentioning

confidence: 99%

Mycobacterium tuberculosis Primary Infection and Dissemination: A Critical Role for Alveolar Epithelial Cells

Ryndak

Laal

2019

Front. Cell. Infect. Microbiol.

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“…Genome analysis revealed that S. saprophyticus ATCC 15305 T does not possess genes coding for common S. aureus virulence factors such as coagulase and enterotoxins but does contain genes responsible for urease production and adhesion to uroepithelial cells, which might be involved in establishing uncomplicated urinary tract infections (Kuroda et al, 2005 ). While S. saprophyticus surface-associated protein and lipase have been suggested as potential virulence factors (Sakinc et al, 2005 , 2007 ; Szabados et al, 2013 ; Tang et al, 2009 ), no investigations into the pathogenicity of S. saprophyticus in the urinary tract or the expression of potential virulence genes in this environment have been published as yet.…”

Section: Classification Habitat and Virulence Of Cnsmentioning

confidence: 99%

Food-derived coagulase-negative Staphylococcus as starter cultures for fermented foods

Heo

Lee

Jeong

2020

Food Sci Biotechnol

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Food safety is of significant concern to consumers and is a major issue for the food industry. As such, the industry is aware of the importance of safety assessments of starters used in the production of fermented foods. Coagulase-negative staphylococci (CNS) are the predominant bacteria found in fermented foods worldwide. Because of this, food-derived CNS are used as starters for cheese and meat fermentation, and have been investigated for use as starters in soybean fermentation. Although food-derived CNS are generally considered non-pathogenic, their safety remains uncertain following the isolation of CNS from skin infections in humans and animals, and because they belong to the same genus as the highly pathogenic species Staphylococcus aureus. This review explores what is known about the safety of food-derived CNS, focusing on antibiotic resistance, enterotoxin genes, and biogenic amine production, to aid in the selection of starter candidates.

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“…S. saprophyticus is primarily a pathogen of the urinary tract, and the factors involved in the mediation of UTI caused by S. saprophyticus are relatively well studied. S. saprophyticus possesses various types of adhesins such as hemagglutinins, autolysin Ass, and surface-associated lipases such as Ssp, which facilitate effective bacterial adherence to fibronectin and fibrinogen and, hence, colonization of the uroepithelium [12][13][14]. It can also form a bacterial biofilm, which confers an anti-phagocytic and antimicrobial-resistance phenotype and increases the virulence of the bacteria [15].…”

Section: Discussionmentioning

confidence: 99%

Emergence of Staphylococcus lugdunensis as a Cause of Urinary Tract Infection: Results of the Routine Use of MALDI-TOF MS

et al. 2020

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We analyzed the incidence and the clinical and laboratory characteristics of Staphylococcus lugdunensis urinary tract infections (UTIs) during a 10-year period (2009–2018) and compared them with those of Staphylococcus saprophyticus UTIs. A total of 38 and 162 episodes of S. lugdunensis and S. saprophyticus UTIs were observed. The number of S. saprophyticus UTIs was stable throughout the 10 years, whereas there was an obvious surge in the apparent number of S. lugdunensis UTIs since 2014, coinciding with the commencement of a routine use of MALDI-TOF MS. Univariate analysis showed that male sex (p < 0.001), advanced age (p < 0.001), hospital-acquired infections, (p < 0.001), upper UTI (p < 0.005), polymicrobial infections (p < 0.05), hypertension (p < 0.001), solid-organ malignancies (p < 0.001), renal stones (p < 0.001), urinary stricture (p < 0.05), vesicoureteral reflux (p < 0.001), and presence of a urinary catheter (p < 0.001) were significantly associated with S. lugdunensis UTI. Multivariable analysis revealed that S. lugdunensis UTI was associated with male sex (OR = 6.08, p < 0.05), solid-organ malignancies (OR = 12.27, p < 0.01), and urological system abnormalities (OR = 7.44, p < 0.05). There were significant differences in the patient population affected and predisposing factors between S. lugdunensis and S. saprophyticus UTIs.

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Staphylococcus saprophyticussurface-associated protein (Ssp) is associated with lifespan reduction inCaenorhabditis elegans

Cited by 11 publications

References 30 publications

Mycobacterium tuberculosis Primary Infection and Dissemination: A Critical Role for Alveolar Epithelial Cells

Mycobacterium tuberculosis Primary Infection and Dissemination: A Critical Role for Alveolar Epithelial Cells

Food-derived coagulase-negative Staphylococcus as starter cultures for fermented foods

Emergence of Staphylococcus lugdunensis as a Cause of Urinary Tract Infection: Results of the Routine Use of MALDI-TOF MS

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