<i>Staphylococcus Epidermidis</i>
            : A Major Player in Bacterial Sepsis?

Otto, Michael

doi:10.2217/fmb-2017-0143

Cited by 52 publications

(44 citation statements)

References 20 publications

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“…severe sepsis, is associated with septic shock with multiorgan dysfunction (5). sepsis develops from a range of bacteria present in the blood when the immune system is compromised (6).…”

Section: Introductionmentioning

confidence: 99%

Miliary tuberculosis complicated by staphylococcal sepsis

Stanojević¹,

Antonijevic²,

Vojinović³

et al. 2018

Medicinski časopis

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“…severe sepsis, is associated with septic shock with multiorgan dysfunction (5). sepsis develops from a range of bacteria present in the blood when the immune system is compromised (6).…”

Section: Introductionmentioning

confidence: 99%

Miliary tuberculosis complicated by staphylococcal sepsis

Stanojević¹,

Antonijevic²,

Vojinović³

et al. 2018

Medicinski časopis

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“…More serious infections ranging from bacterial meningitis and cerebral abscesses to necrotizing fasciitis have been reported to be a result of Enterobacter Cloacae as well [16,17]. Micrococcus luteus has been reported in the development of cases of endocarditis and septic arthritis [18,19]. Recent literature agrees that Staphylococcus epidermidis is one of the most frequent pathogens underlying the development of bacteremia and suggests that bacterial sepsis from S. epidermidis may be more species level for evaluation of the depth of microflora present and for possible pathogens.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Bacterial Contamination of Casting Material in a Pediatric Population

Amato

Palyvoda

Vangipuram

et al. 2020

International Journal of Pediatrics

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Surgical site infection is a relatively common and devastating complication following pediatric orthopedic surgery. Many infections have been determined to be the result of settled airborne particles on surgical equipment and the sterile field. Fiberglass casts are commonly used orthopedic fixation devices before and after surgery; however, fiberglass casting material is expelled during the removal process and represents an uninvestigated area for the possibility of cast saw dust as a source of airborne bacterial contamination in an operating room setting. This study evaluates the prevalence and distribution of microbiota on 90 pediatric casts by collecting and culturing fiberglass cast material from 90 pediatric casts. Bacterial identification was performed using a Bruker Biotyper Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry device. 81 out of 90 casts (90%) showed evidence of microbial contamination. Isolated species were very diverse and ranged from normal skin flora to opportunistic pathogens. The 5 most commonly isolated organisms were Acinetobacter pittii, Enterobacter cloacae, Micrococcus luteus, Staphylococcus epidermidis, and Staphylococcus hominis. Further investigation is required to determine if casting material is truly a cause of surgical site infection.

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“…It is also frequently recovered from bacteremia and sepsis samples in neonatal care clinic units, being its most probable etiological agent (Byrd et al 2018;Otto 2009). In clinical practice, it is difficult to assess if SE clones are the causal agents of the disease, are accidental, or opportunistic pathogens (Miragaia et al 2008;Otto 2017). In this work, we conducted a survey at the Instituto Nacional de Perinatología "INPer" in México City, over a period spanning eight years, to register changes in the antibiotic profile of staphylococci species and strains.…”

Section: Discussionmentioning

confidence: 99%

Peer Review #3 of "Genomic diversity of prevalent Staphylococcus epidermidis multidrug-resistant strains isolated from a Children’s Hospital in México City in an eight-years survey (v0.4)"

2019

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Staphylococcus epidermidis is a human commensal and pathogen worldwide distributed. In this work, we surveyed for multi-resistant S. epidermidis strains in eight years at a children's health-care unit in México City. Multidrug-resistant S. epidermidis were present in all years of the study, including resistance to methicillin, beta-lactams, fluoroquinolones, and macrolides. To understand the genetic basis of antibiotic resistance and its association with virulence and gene exchange, we sequenced the genomes of 17 S. epidermidis isolates. Whole-genome nucleotide identities between all the pairs of S. epidermidis strains were about 97% to 99%. We inferred a clonal structure and eight Multilocus Sequence Types (MLST´s) in the S. epidermidis sequenced collection. The profile of virulence includes genes involved in biofilm formation and phenol-soluble modulins (PSMs). Half of the S. epidermidis analyzed lacked the ica operon for biofilm formation. Likely, they are commensal S. epidermidis strains but multi-antibiotic resistant. Uneven distribution of insertion sequences, phages, and CRISPR-Cas immunity phage systems suggest frequent horizontal gene transfer. Rates of recombination between S. epidermidis strains were more prevalent than the mutation rate and affected the whole genome. Therefore, the multidrug resistance, independently of the pathogenic traits, might explain the persistence of specific highly adapted S. epidermidis clonal lineages in nosocomial settings.

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Staphylococcus Epidermidis : A Major Player in Bacterial Sepsis?

Abstract: biofilm • coagulase-negative staphylococci • phenol-soluble modulins • sepsis • Staphylococcus epidermidis • toxin

Cited by 52 publications

References 20 publications

Miliary tuberculosis complicated by staphylococcal sepsis

Miliary tuberculosis complicated by staphylococcal sepsis

Prevalence of Bacterial Contamination of Casting Material in a Pediatric Population

Peer Review #3 of "Genomic diversity of prevalent Staphylococcus epidermidis multidrug-resistant strains isolated from a Children’s Hospital in México City in an eight-years survey (v0.4)"

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