2023
DOI: 10.1101/2023.10.27.564475
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Staphylococcus aureusPersistence in Osteocytes: Weathering the Storm of Antibiotics and Autophagy/Xenophagy

Nicholas J. Gunn,
Anja R. Zelmer,
Stephen P. Kidd
et al.

Abstract: BackgroundStaphylococcus aureusis a major causative pathogen of osteomyelitis. Intracellular infection of osteocytes and other bone cell types have been reported, with the bacteria able to survive and persist for an extended period, despite application of gold-standard clinical interventions. The mechanisms, by which intracellularS. aureuspersists through antibiotic therapy are unknown. In this study we investigated if antibiotic-mediated dysregulation of autophagy is a contributing factor.MethodsHuman osteocy… Show more

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