<i>Staphylococcus aureus</i> intracellular survival: A closer look in the process

Singh, Sanjay K.

doi:10.1080/21505594.2017.1384896

Cited by 13 publications

(10 citation statements)

References 11 publications

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“…To survive, bacteria must quickly adapt to changing environmental conditions. To date, dozens of group-or species-specific and universal adaptive mechanisms have been uncovered (Anderson and Kendall, 2017;Singh, 2017;Bussi and Gutierrez, 2019). Among them, changes in the architecture of the entire chromosome or particular chromosome regions (e.g., gene promoters) appear to be the most rapid and effective adaptation strategies, particularly in response to sudden stress (Boor, 2006;Morikawa et al, 2006;Trojanowski et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Nucleoid Associated Proteins: The Small Organizers That Help to Cope With Stress

Hołówka

Zakrzewska‐Czerwińska

2020

Front. Microbiol.

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The bacterial chromosome must be efficiently compacted to fit inside the small and crowded cell while remaining accessible for the protein complexes involved in replication, transcription, and DNA repair. The dynamic organization of the nucleoid is a consequence of both intracellular factors (i.e., simultaneously occurring cell processes) and extracellular factors (e.g., environmental conditions, stress agents). Recent studies have revealed that the bacterial chromosome undergoes profound topological changes under stress. Among the many DNA-binding proteins that shape the bacterial chromosome structure in response to various signals, NAPs (nucleoid associated proteins) are the most abundant. These small, basic proteins bind DNA with low specificity and can influence chromosome organization under changing environmental conditions (i.e., by coating the chromosome in response to stress) or regulate the transcription of specific genes (e.g., those involved in virulence).

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Section: Introductionmentioning

confidence: 99%

Nucleoid Associated Proteins: The Small Organizers That Help to Cope With Stress

Hołówka

Zakrzewska‐Czerwińska

2020

Front. Microbiol.

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“…S. aureus uses the ability to survive inside the phagosomes of neutrophils and through a mechanism to avoid the fusion of phagosomes and lysosomes in neutrophils. When neutrophils die by necrosis, their contents spread out, which is harmful to the surrounding tissues and may further bring about a second wave of attack [ 7 ]. Str.…”

Section: Introductionmentioning

confidence: 99%

Effect of Lipopolysaccharide and Muramyl Dipeptide on Apoptosis of Bovine Mammary Gland Lymphocytes

Sláma

Kabourková

Sládek

et al. 2020

Animals

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The aim of this study was to evaluate whether apoptosis of lymphocytes is modulated by stimulation by lipopolysaccharide (LPS) of Escherichia coli or muramyl dipeptide (MDP). Cell populations were obtained by lavaging of the mammary glands 24, 48, 72, and 168 h following intramammary induced inflammation. The portion of apoptotic lymphocytes peaked at 48 h after treatment with LPS or MDP. The analysis of CD44 expression of the same cell populations showed a higher percentage of CD44-positive lymphocytes 24- and 48-h following induction of inflammation by LPS or MDP. The results demonstrate that during both experimental infection of bovine mammary glands with LPS or MDP, apoptosis of lymphocytes was induced in the initial phase of the inflammatory response and CD44 was also overexpressed at the beginning of inflammation. These data suggest a connection of lymphocyte apoptosis with the expression of CD44 receptors.

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“…The present short presentation suggests a novel approach which may shed a new light on how staphylococci and their secreted pro-inflammatory agent [2] and immune complexes can act in concert with polycations, and with exo products released from activated PMNs [10][11][12][13] to injure skin as seen in AD. Internalized staphylococci [18][19][20][21][22][23][24] may persist intra cellularly, unharmed, and capable of re-emerging from cells to re attack skin. Treatment of Atopic Dermatitis with Biologic Drugs my better ameliorate the viscous toxic cycles [27,28].…”

Section: Resultsmentioning

confidence: 99%

“…Intra cellularly, viable staphylococci may be now protected and can survive unharmed until the immune system the host is lowered and can now have a chance for a re attack employing their rich arsenal of pro-inflammatory agents [2] to injure the skin cells [18][19][20][21][22][23][24].…”

Section: About the Studymentioning

confidence: 99%

A Novel Approach That May Explain the Role of Staphylococcus aureus, Polycations, Neutrophils Pro-Inflammatory Agonists and the Bacteriolysis and Auto Immune Phenomena as Possible Major Events in the Pathogenesis of Atopic Dermatitis: A Working Hypothesis

Ginsburg¹,

Koren²

2019

J Clin Exp Dermatol Res

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Staphylococcus aureus intracellular survival: A closer look in the process

Cited by 13 publications

References 11 publications

Nucleoid Associated Proteins: The Small Organizers That Help to Cope With Stress

Nucleoid Associated Proteins: The Small Organizers That Help to Cope With Stress

Effect of Lipopolysaccharide and Muramyl Dipeptide on Apoptosis of Bovine Mammary Gland Lymphocytes

A Novel Approach That May Explain the Role of Staphylococcus aureus, Polycations, Neutrophils Pro-Inflammatory Agonists and the Bacteriolysis and Auto Immune Phenomena as Possible Major Events in the Pathogenesis of Atopic Dermatitis: A Working Hypothesis

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