<i>Sleep Deprivation and Vigilant Attention</i>

Lim, Julian; Dinges, David F.

doi:10.1196/annals.1417.002

Cited by 1,007 publications

(888 citation statements)

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“…However they are comparable to the findings from Van de Werken [44], showing that the reaction times under DsL were similar to the one under control condition. One could argue that the PVT needs a higher and, more probably, a sustained level of arousal than the SART test -which is not reached here -to get to optimal performance levels, since this task is much more monotonous with much fewer stimuli (e.g., [45]). The absence of a significant effect could be traced back to the fact that we compared reaction times after one night of sleep restriction between two light conditions.…”

Section: Discussionmentioning

confidence: 85%

Dawn simulation light impacts on different cognitive domains under sleep restriction

Gabel

Maire

Reichert

et al. 2015

Behavioural Brain Research

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Section: Discussionmentioning

confidence: 85%

Dawn simulation light impacts on different cognitive domains under sleep restriction

Gabel

Maire

Reichert

et al. 2015

Behavioural Brain Research

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“…Finally, we did not collect any type of psychomotor vigilance data, reaction time data, or attentional measurements. Several studies have suggested that sleep deprivation has a major impact on sustained attention [46,47]. Thus, it could be that the observed sleep deprivation-related impairments in RGDT and SSWT performance were a result of brief attentional lapses rather than an impairment of CAP per se.…”

Section: Discussionmentioning

confidence: 98%

Effects of sleep deprivation on central auditory processing

et al. 2012

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BackgroundSleep deprivation is extremely common in contemporary society, and is considered to be a frequent cause of behavioral disorders, mood, alertness, and cognitive performance. Although the impacts of sleep deprivation have been studied extensively in various experimental paradigms, very few studies have addressed the impact of sleep deprivation on central auditory processing (CAP). Therefore, we examined the impact of sleep deprivation on CAP, for which there is sparse information. In the present study, thirty healthy adult volunteers (17 females and 13 males, aged 30.75 ± 7.14 years) were subjected to a pure tone audiometry test, a speech recognition threshold test, a speech recognition task, the Staggered Spondaic Word Test (SSWT), and the Random Gap Detection Test (RGDT). Baseline (BSL) performance was compared to performance after 24 hours of being sleep deprived (24hSD) using the Student’s t test.ResultsMean RGDT score was elevated in the 24hSD condition (8.0 ± 2.9 ms) relative to the BSL condition for the whole cohort (6.4 ± 2.8 ms; p = 0.0005), for males (p = 0.0066), and for females (p = 0.0208). Sleep deprivation reduced SSWT scores for the whole cohort in both ears [(right: BSL, 98.4 % ± 1.8 % vs. SD, 94.2 % ± 6.3 %. p = 0.0005)(left: BSL, 96.7 % ± 3.1 % vs. SD, 92.1 % ± 6.1 %, p < 0.0001)]. These effects were evident within both gender subgroups [(right: males, p = 0.0080; females, p = 0.0143)(left: males, p = 0.0076; females: p = 0.0010).ConclusionSleep deprivation impairs RGDT and SSWT performance. These findings confirm that sleep deprivation has central effects that may impair performance in other areas of life.

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“…The PVT is a reaction-time task that has been validated in laboratory, clinical, and field studies investigating sleep, respiratory, and neurological disorders. [18][19][20] The PVT has been demonstrated to be highly sensitive to sleep loss and can easily be used in a clinical setting. We also assessed other factors, including demographics, disability, pain, mood, and sleep quality, to assess their relative contribution to psychomotor vigilance performance in this population.…”

Section: Original Articlementioning

confidence: 99%

Multiple Sclerosis Fatigue is Associated with Reduced Psychomotor Vigilance

Rotstein

O’Connor²,

Lee³

et al. 2012

Can. J. Neurol. Sci.

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Fatigue is a common and disabling symptom in those who suffer from multiple sclerosis (MS). Studies indicate that more than 75% of MS patients suffer from fatigue. 1-3 Two-thirds of MS patients rank fatigue as one of their three most debilitating symptoms. 1 Multiple sclerosis fatigue is particularly aggravated by heat and can significantly impair physical activity. 1 It is one of the main causes of work absenteeism in individuals with MS. 4 Yet fatigue is a lay term that remains subjectively defined and assessment of fatigue is therefore dependent on self-report. Perhaps as a result, the physiologic substrates of MS fatigue are not well-described. The subjective experience of fatigue is multifactorial and has been correlated with factors such as disability, depression, and pain. [5][6][7] Interestingly, no clear association has been established between MS fatigue and demographic factors, such as age and gender; lesion burden; or the clinical form of MS. 1,[7][8][9] ABSTRACT: Background: Fatigue is common and disabling in multiple sclerosis, yet its physiologic substrates remain poorly defined. The aim of this study was to determine the relationship between fatigue and an objective measure of alertness in MS patients. Methods: This study enrolled 49 consecutive MS clinic patients at two academic hospitals in Toronto. Alertness was assessed with the psychomotor vigilance test (PVT), a ten-minute reaction-time test that measures attention and is sensitive to sleep loss. Patients with visual impairment or arm weakness were excluded. Validated tools were used to assess fatigue, disability, mood, and pain. Results: The average age was 43; 65% were women. Median EDSS was 2.0 (range 0-7.5). Fifty-five percent reported a high impact of fatigue on their lives. Psychomotor vigilance test performance was worse than in an age-and sex-matched population, with a mean reaction time of 315 msecs and 3.98 lapses >500 msec (p<0.001). In a multiple regression analysis, fatigue was the most significantly correlated factor with mean PVT reaction time (p<0.05), and disability was also significantly correlated (p<0.01). Mood and pain did not correlate with the PVT. Eighteen (37%) reported often experiencing restlessness in their legs at night. Conclusion: Subjective fatigue and disability were associated with poor performance on alertness testing in MS patients. This research highlights a potential role for psychomotor vigilance testing in providing a standardized assessment tool for an important aspect of MS-related fatigue.RÉSUMÉ: La fatigue dans la sclérose en plaques est associée à une diminution de la vigilance psychomotrice. Contexte : La fatigue est un symptôme fréquent et invalidant chez les patients atteints de la sclérose en plaques (SP) et sa cause physiologique demeure mal définie. Le but de cette étude était de déterminer la relation entre la fatigue et une mesure objective de vigilance chez des patients atteints de la SP. Méthode : Nous avons inclus 49 patients consécutifs de cliniques de SP situées dans deux hôpitaux ac...

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Sleep Deprivation and Vigilant Attention

Cited by 1,007 publications

References 130 publications

Dawn simulation light impacts on different cognitive domains under sleep restriction

Dawn simulation light impacts on different cognitive domains under sleep restriction

Effects of sleep deprivation on central auditory processing

Multiple Sclerosis Fatigue is Associated with Reduced Psychomotor Vigilance

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