Abstract:The Six3 transcription factor is essential for forebrain and eye development, and SIX3 mutations cause the congenital disorder holoprosencephaly. We created a six3 mutant in Xenopus tropicalis with a mild holoprosencephaly phenotype, and unlike mouse Six3 mutants that are headless/eyeless, the Xenopus mutant forms some eye structures, allowing direct study of Six3 function in eye formation. We focus here on striking deficits in lens formation. Early lens induction occurs normally in the mutant, e.g., the essen… Show more
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