SignalingProfiler2.0: a network-based approach to bridge multi-omics data to phenotypic hallmarks
Veronica Venafra,
Francesca Sacco,
Livia Perfetto
Abstract:Unraveling the cellular signaling remodeling upon a perturbation is a fundamental challenge to understand disease mechanisms and to identify potential drug targets. In this pursuit, computational tools that generate mechanistic hypotheses from multi-omics data have invaluable potential. Here we present SignalingProfiler 2.0, a multi-step pipeline to systematically derive context-specific signaling models by integrating proteogenomic data with prior knowledge-causal networks. This is a freely accessible and fle… Show more
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