<i>Shigella flexneri</i>perinephric abscess and bacteremia

Alsoub, Hussam; Al-Maslamani, Mona; Al-Khuwaiter, Jameela; Eldeeb, Yasser; Elshafie, Sittana S.

doi:10.5144/0256-4947.2005.419

Cited by 2 publications

(4 citation statements)

References 14 publications

(19 reference statements)

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“…In addition, the α-diversity in the IP group was unchanged until day 4, which was 3 days after Shigella infection induction. In the present study the dose challenge in the IP group was set as 5x10 7 CFU in order to reduce the incidence of mortality; this dosage was lower than that used by both Yang et al (13) and Sharma et al (27), at 5x10 8 CFU and 10 8 CFU, respectively. In these previous studies, all mice in the IP group died within 7 days (13,27).…”

Section: Discussionmentioning

confidence: 99%

“…are usually self-limiting and confined to the mucosa of the distal ileum and the colon (26). However, in rare cases, parenteral infection can lead to bacteremia, multiple organ infections and abscesses (7). In order to investigate the differences in the effects of Shigella intestinal infection and parenteral infection on gut microbiota, and the possible role of gut microbiota in the different infection routes, a Shigella infection mouse model was established by IP injection and gavage in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…The lesions are mainly confined to the colon, and result in mucosal congestion, edema and inflammatory cell infiltration between the ulcers (5) Bacteremia with Shigella is rare, especially in adults (6). In addition to the common route of oral infection, Shigella can also cause damage to multiple organs via the route of extra-intestinal infection, such as kidney and spleen abscesses induced by bacteremia (7,8), perihepatitis-salpingitis caused by unhygienic sexual practices, and vulvovaginitis induced by fecal contamination (9,10). In particular, when Shigella infection is combined with intestinal perforation, appendicitis and peritonitis, clinical manifestations of abdominal infection, such as high fever and septicemia, may occur with a high mortality rate (11).…”

Section: Introductionmentioning

confidence: 99%

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Dynamic comparison of gut microbiota of mice infected with Shigella�flexneri via two different infective routes

Yang

Chen²,

Xia³

et al. 2020

Exp Ther Med

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Shigella is one of the main pathogens causing diarrheal disease, and is associated with high morbidity and mortality in developing countries. Previous clinical data and animal studies have shown that the outcomes of oral and peritoneal infections of Shigella differ, and that the latter is more serious. Furthermore, a variety of pathogenic bacteria are known to cause changes in intestinal flora after infection, and the influence of Shigella infection on intestinal flora remains poorly understood. In the present study, the 16S rRNA high-throughput sequencing method was used to compare the changes in gut microbiota profiles in feces of mice infected with Shigella via two routes. In addition, the present study investigated the association between the differences in infection performance and bacterial communities. The present results suggested that the intraperitoneal route induced a distinct decrease in α-diversity in the fecal microbiota when compared to the control at a later time, while the effect of the oral route on α-diversity was not obvious. Oral infection of Shigella had a rapid and significant effect on gut microbiota, mainly causing a decreased abundance of Lactobacillus and an increased abundance of Prevotella and Escherichia/Shigella in the early stage of infection. By contrast, the effect of intraperitoneal infection on the gut microbiota was relatively slow and small. The principal coordinate analysis results suggested that the dynamic profile of gut microbiota between the two infective routes was consistent with the infection process. Probiotics, such as Lactobacillus reuteri and Faecalitalea exhibited significantly reduced abundance after Shigella infection. Collectively, the present results suggested that gut microbiota may play a pivotal role in the pathogenesis of Shigella infection. Future studies should investigate the effect of Shigella infection on the interaction between pathogenic bacteria and intestinal flora. The present results suggested that the use of probiotics may facilitate the prevention and treatment of shigellosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dynamic comparison of gut microbiota of mice infected with Shigella�flexneri via two different infective routes

Yang

Chen²,

Xia³

et al. 2020

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…A host of other unusual bacteria have also been reported. Among those, Shigella flexneri [37], Stenotrophomonas maltophilia [38], Nocardia [39] group B streptococcus [40], Candida glabrata [41], Aspergillus fumigates [42], Listeria monocytogenes [43], coagulase-negative Staphylococcus [44], Salmonella [45], Torulopsis glabrata [46,47], Bacteroides fragilis [48] and Trichomonas vaginalis [49] have been reported to cause perinephric abscess in non-transplant patients. Mycoplasma hominis [50], Streptococcus agalactiae [51], Nocardia [52], and Gardnerella vaginalis [53] have been reported to cause perinephric abscess in patients with kidney graft.…”

Section: Pathophysiologymentioning

confidence: 99%