Abstract:SummaryDuring infection, a subset of bacterial pathogens invades into the eukaryotic cytosol and spreads between cells of an epithelial layer. This intercellular spread is essential for disease and requires actin-based motility leading to the formation of plasma membrane protrusions. Protrusions are engulfed by the adjacent cell in an active process requiring both bacterial and eukaryotic proteins. Here, we demonstrate that the Shigella spp. type 3 secretion system protein IpaC promotes bacterial spread by red… Show more
To combat infectious diseases, it is important to understand how host cells interact with bacterial pathogens. Signals conveyed from pathogen to host, and vice versa, may be either chemical or mechanical.
To combat infectious diseases, it is important to understand how host cells interact with bacterial pathogens. Signals conveyed from pathogen to host, and vice versa, may be either chemical or mechanical.
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