<i>Shewanella putrefaciens</i>bacteraemia associated with terminal ileitis

Yiallouros, Panayiotis K.; Mavri, Antonia; Attilakos, Achilleas; Moustaki, Maria; Leontsini, Fani; Karpathios, Themistocles

doi:10.1179/2046905512y.0000000045

Cited by 9 publications

(2 citation statements)

References 12 publications

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“…biliary tract infections, empyema, endocarditis, dacryocystitis, intracranial abscess, arthritis, peritonitis, ventilator-associated pneumonia and ear infections (Ananth et al, 2014;Constant et al, 2014;Dey et al, 2015;Goyal et al, 2011;Holt et al, 2005;Sharma & Kalawat, 2010;Yiallouros et al, 2013). Shewanella spp.…”

Section: Introductionmentioning

confidence: 99%

Genome analysis of a clinical isolate of Shewanella sp. uncovered an active hybrid integrative and conjugative element carrying an integron platform inserted in a novel genomic locus

et al. 2016

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Shewanella spp. are currently considered to be emerging pathogens that can code for a bla OXA carbapenemase in their chromosome. Complete genome analysis of the clinical isolate Shewanella sp. Sh95 revealed that this strain is a novel species, which shares a lineage with marine isolates. Characterization of its resistome showed that it codes for genes drfA15, qacH and bla OXA-48. We propose that Shewanella sp. Sh95 acts as reservoir of bla . Moreover, analysis of mobilome showed that it contains a novel integrative and conjugative element (ICE), named ICESh95. Comparative analysis between the close relatives ICESpuPO1 from Shewanella sp. W3-18-1 and ICE SXT MO10 from Vibrio cholerae showed that ICESh95 encompassed two new regions, a type III restriction modification system and a multidrug resistance integron. The integron platform contained a novel arrangement formed by gene cassettes drfA15 and qacH, and a class C-attC group II intron. Furthermore, insertion of ICESh95 occurred at a unique target site, which correlated with the presence of a different xis/ int module. Mobility of ICESh95 was assessed and demonstrated its ability to self-transfer with high efficiency to different species of bacteria. Our results show that ICESh95 is a selftransmissible, mobile element, which can contribute to the dissemination of antimicrobial resistance; this is clearly a threat when natural bacteria from water ecosystems, such as Shewanella, act as vectors in its propagation.

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Section: Introductionmentioning

confidence: 99%

Genome analysis of a clinical isolate of Shewanella sp. uncovered an active hybrid integrative and conjugative element carrying an integron platform inserted in a novel genomic locus

et al. 2016

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“…Furthermore, Shewanella often causes skin and soft tissue infections, ear, nose, and throat-related diseases, chest and abdominal cavity infections, blood infections, and even cardiovascular and central nervous system diseases ( Yu et al, 2022 ), causing widespread concern both domestically and internationally. Such bacteria have been isolated from clinical samples of patients with diarrhea in recent years ( Yiallouros et al, 2013 ; Dey et al, 2015 ; Fang et al, 2017 ). Yonglu et al (2009) isolated them for the first time from patients with food poisoning.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and molecular characteristics of Shewanella infection in diarrhea patients in Beijing, China 2017–2019

Kang,

Yu,

Huang

et al. 2024

Front. Microbiol.

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IntroductionShewanella is an important opportunistic pathogen distributed in marine environments that has caused an increasing number of clinical infections. However, there are few reports on the distribution and characteristics of Shewanella in the diarrheal pathogen spectrum. In this study, we have systematically described the prevalence of Shewanella infections in diarrhea patients in Beijing, China 2017–2019, and genome characteristics and antimicrobial susceptibility of Shewanella isolates.MethodsStool samples were collected from diarrhea patients in a surveillance project from 2017 to 2019. Shewanella strains were isolated, and identified using VITEKR 2 COMPACT and MALDI-TOF MS. Average nucleotide identity (ANI) analysis, multi-locus sequence typing (MLST), phylogenetic analysis, virulence-associated genes and antimicrobial resistance genes analysis were used for genome characteristics description. The antibiotic susceptibility test was performed with microbroth dilution method.Results1104 fecal samples were collected, and the Shewanella detection rate was 2.36% (26/1104). The main manifestations of infection caused by Shewanella spp. were diarrhea (100%, 26/26), abdominal pain (65.38%, 17/26), and vomiting (38.46%, 10/26). The 26 isolates were classified into 3 species (S. algae (n = 18), S. indica (n = 5), and S. chilikensis (n = 3)) and 22 sequence types. Core genome single nucleotide polymorphism-based evolutionary tree identified three clone groups corresponding to three infection events in the same months in 2017 and 2019. The putative virulence-associated gene pool consisted of 56 potential virulence genes, including 19 virulence gene factors. The resistance rates of the 26 isolates to 17 antibiotics from high to low were as follows: polymyxin E (76.92%), cefotaxime (57.69%), ampicillin (50%), ampicillin-sulbactam (34.62%), nalidixic acid (15.38%), ciprofloxacin (11.54%), selectrin (3.846%,1/26), and tetracycline (3.846%, 1/26). The rate of multidrug resistance was 38.46% (10/26).DiscussionMonitoring for Shewanella spp. should be added to the routine surveillance of infectious diarrhea during the epidemic season.

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Shewanella: a Marine Pathogen as an Emerging Cause of Human Disease

Janda

2014

Clinical Microbiology Newsletter

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Shewanella putrefaciensbacteraemia associated with terminal ileitis

Cited by 9 publications

References 12 publications

Genome analysis of a clinical isolate of Shewanella sp. uncovered an active hybrid integrative and conjugative element carrying an integron platform inserted in a novel genomic locus

Genome analysis of a clinical isolate of Shewanella sp. uncovered an active hybrid integrative and conjugative element carrying an integron platform inserted in a novel genomic locus

Prevalence and molecular characteristics of Shewanella infection in diarrhea patients in Beijing, China 2017–2019

Shewanella: a Marine Pathogen as an Emerging Cause of Human Disease

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