Serratia marcescens as a cause of unfavorable outcome in the twin pregnancy

Abstract

Several Serratia species are widely distributed in nature, but Serratia marcescens is the only species frequently isolated in hospitals. This pathogen is mainly responsible for nosocomial infection, mostly in immunocompromised hosts. A 26-year-old woman with a twin pregnancy, regularly controlled, was hospitalized at 24 + 5 weeks of gestation due to scant vaginal bleeding, lower abdominal pain, and body temperature up to 37.5°C. Gynecological examination revealed bleeding accompanied by dilatation of the cervix. The laboratory analyses revealed leukocytosis with elevated C-reactive protein (CRP). Treatment was initiated with intravenous antibiotic administration. After admission, fetal membranes spontaneously ruptured, and an extremely preterm dichorionic female twin birth occurred at 25 + 0 weeks of gestation. Both infants died two days after labor. Pathological and microbiological analyses revealed chorioamnionitis caused by S. marcescens. According to the antibiogram, antibiotic treatment was continued for the next 7 days. The examination of cervical and vaginal discharge samples was negative three days and two weeks after therapy. S. marcescens may cause spontaneous miscarriages and, in this important case, caused loss of discordant twins in an extremely preterm birth by an immunocompetent patient. Infection by S. marcescens cannot be excluded as a cause of discordant growth and needs to be confirmed by further research.

Molecular Detection of Serratia Marcescens Isolated From Different Clinical Cases in Wasit Province, Iraq

“…Serratia marcescens is a rod-shaped Gram-negative bacterium that belongs to the family Enterobacteriaceae (Allen et al, 2022). It is a facultative anaerobic bacterium that can grow in the presence and absence of oxygen at temperatures 30-37°C (Ferreira et al, 2018;Kljakić et al, 2021). Serratia marcescens become an opportunist thogen causing pa nosocomial infections and is commonly involved inhospital-acquired infections (HAIs); especially urinary tract infections (UTIs), pneumonia, septicemia, meningitis ,and wound infections (Prado et al, 2021).…”