Senecio serratuloides extract prevents the development of hypertension, oxidative stress and dyslipidemia in nitric oxide-deficient rats

Abstract

<jats:title>Abstract</jats:title><jats:sec id="j_jcim-2018-0073_s_001a_w2aab3b7c31b1b6b1aab1c15b1Aa"><jats:title>Background</jats:title><jats:p>Hypertension is a silent killer with no obvious signs and symptoms; thus, it is crucial to prevent its development. Oxidative stress and hyperlipidemia are associated risk factors for developing hypertension. This study aimed at investigating the role of a crude extract of <jats:italic>Senecio serratuloides</jats:italic> in preventing the development of hypertension, oxidative stress and hyperlipidemia in a rat model of nitric oxide deficiency.</jats:p></jats:sec><jats:sec id="j_jcim-2018-0073_s_001b_w2aab3b7c31b1b6b1aab1c15b2Aa"><jats:title>Methods</jats:title><jats:p>Female Wistar rats were co-treated with Nω-Nitro L-arginine methyl ester (L-NAME) (40 mg/kg) and the hydroethanolic extract of <jats:italic>S. Serratuloides</jats:italic> (HESS150 or HESS300 mg/kg) for 4 weeks. Twenty-hour urine samples were collected weekly during the study. At the end of the study serum, heart and kidneys were harvested for biochemical and histopathological analysis.</jats:p></jats:sec><jats:sec id="j_jcim-2018-0073_s_001c_w2aab3b7c31b1b6b1aab1c15b3Aa"><jats:title>Results</jats:title><jats:p>The higher dose (300 mg/kg) of the extract was more effective in preventing increase in systolic (p&lt;0.001) and diastolic (p&lt;0.05) blood pressure. At the end of the treatment period HESS300 treated rats had significantly (p&lt;0.01) higher concentration of creatinine (91.24 ± 6 mg/dL) in urine and significantly (6.36 ± 0.4 mg/24 h; 0.001) lower proteinuria compared to L-NAME control rats (55.75 ± 8 mg/dL and 18.92 ± 2 mg/24 h, respectively). Creatinine clearance and glomerular filtration rate were lower in the L-NAME control group compared to all treatment groups. HESS300 prevented L-NAME-induced decrease in serum angiotensin II concentration, significantly decreased malondialdehyde concentration in serum (p&lt;0.05) and kidneys (p&lt;0.001). It also significantly (p&lt;0.001) decreased low-density lipoprotein concentration while increasing the concentration of high-density lipoprotein cholesterol. It showed cardio- and reno-protective effects and significantly (p&lt;0.01) prevented collagen deposition in these target organs.</jats:p></jats:sec><jats:sec id="j_jcim-2018-0073_s_001d_w2aab3b7c31b1b6b1aab1c15b4Aa"><jats:title>Conclusion</jats:title><jats:p>These findings demonstrate the potential of <jats:italic>S. Serratuloides</jats:italic> in protecting rats from developing hypertension, hyperlipidemia and oxidative stress.</jats:p></jats:sec>

Phytochemical characterization ofMorus nigrafruit ultrasound‐assisted ethanolic extract for its cardioprotective potential

“…Hyperlipidemia and oxidative stress are highly correlated to developing vascular abnormal contractions (Tata et al, 2020). The present investigation revealed a considerable decrease in elevated blood pressure caused by high cholesterol supplementation and cigarette smoke exposure in M. nigra fruit‐treated rats.…”

“…Hyperlipidemia and oxidative stress are highly correlated to developing vascular abnormal contractions (Tata et al, 2020). The Accordingly, a marked decrease in systolic and diastolic blood pressure and heart rate in isolated rat aorta due to verapamil (Simonovic et al, 2019).…”

Preventing ethanol-induced stomach ulcers in rats using Senecio perralderianus leaf extract

“…On the other hand, administration of different doses of S. perralderianus resulted in an increase in CAT activity, an increase in GSH content and a significant decrease in gastric lipid peroxidation. However, the plasma MDA content was elevated following pre-treatment with ethanol extract of S. Serratuloides in the arterial hypertension model [27]. In the CCl4-induced oxidative model conducted by Okoro and Kadiri [28] using the aqueous extract of S. Biafrae roots demonstrated an increase in GSH content, an intensification in the enzymatic activity of CAT and SOD; with a strong reduction in MDA content in the time, suggesting an in vivo antioxidant activity.…”

Pingyang Jiangya Fang pretreatment reduces the blood pressure of spontaneously hypertensive rats with Liver-Yang hyperactivity syndrome via ROS/Akt oxidative stress pathway

“…It modifies various signal pathways and transcriptional regulation which influence glucose metabolism and damage β-cell function, eventually leading to IR. Occurrence and the generation of reactive oxygen species (ROS) is the fundamental incentive (9). For instance, ROS induces hypertension via the central and peripheral pathways, as well as participate in target organ damage (10).…”