<i>SECTION OF BIOLOGY</i>*: PHARMACOLOGY AND THERAPEUTIC VALUE OF DIAMIDINE DERIVATIVES—PARTICULARLY OF 2‐HYDROXYSTILBAMIDINE†

Snapper, I.; Schneid, B.; McVay, Leon V.; Lieben, Fritz

doi:10.1111/j.2164-0947.1952.tb01118.x

Cited by 46 publications

(5 citation statements)

References 8 publications

(1 reference statement)

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“…120 This aromatic diamidine does not cause the toxic neurological effect which was almost universally recorded with stilbamidine when the latter drug was given in doses greater than 1 Gm.120-125 Very excellent reviews have been reported on the aromatic diamidin e s . 120 nausea, vomiting, marked anorexia, chills, and fever were reported in the same patients. Nevertheless, these authors conclude that amphotericin B is the drug of choice for disseminated North American blastomycosis.…”

Section: North American Blastomycosissupporting

confidence: 59%

Modern treatment of the systemic fungus diseases

Harrell

Bocobo

1960

Clin Pharma and Therapeutics

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For many years the systemic fungus diseases received little attention from the members of the medical profession and in the curriculum of the medical schools in the United States. Recently there has been a gradual awakening to their importance. The introduction of increasing numbers of antifungal chemotherapeutic agents attest this new interest in the mycotic diseases. Beneficial or curative specific therapy is now possible for many of these diseases which previously were without effective means of treatment.

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Section: North American Blastomycosissupporting

confidence: 59%

Modern treatment of the systemic fungus diseases

Harrell

Bocobo

1960

Clin Pharma and Therapeutics

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“…It is used in the treatment of various protozoal and mycotic infections and may be used for a prolonged period (Snapper, Schneid, McVay, and Lieben, 1952). It may be incorporated into cells and remain active for long periods (Snapper, Schneid, Greenspan, and Lieben, 1950).…”

Section: Resultsmentioning

confidence: 99%

Sensitivity ofHartmannella(Acanthamoeba) to5-fluorocytosine, hydroxystilbamidine, and other substances

Casemore¹

1970

J Clin Pathol

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SYNOPSISThe effect of 24 anti-amoebic and other chemotherapeutic compounds on six strains of hartmannellid amoebae was studied by tissue culture, agar diffusion, and liquid axenic culture.Of the recognized anti-amoebic compounds only one inhibited growth of the amoebae, which were remarkable for their resistance.Two compounds, hydroxystilbamidine isethionate and 5-fluorocytosine, showed some amoebicidal activity while some others were inhibitory.

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“…I n the past few years there has been renewed interest in the design and development of aromatic diamidino compounds that exhibit specific DNA-binding modes as well as important biological and therapeutic applications (Krugh, 1994;Wilson, 1990;Zimmer and Wähnert, 1986). The leading drugs, berenil and 2-hydroxystilbamidine (and other similar compounds), have relevant trypanocidal, fungicidal, and anti-tumor activities (Zimmer and Wähnert, 1986;Baguley, 1982;Newton, 1975;Snapper et al, 1952). In addi-tion, some aromatic diamidines have been shown to inhibit the reverse transcriptase from oncogenic RNA viruses (De Clerq and Dann, 1980) and DNA topoisomerase II activity in kinetoplast DNA from trypanosomes (Shapiro and Englund, 1990;Woynarowski et al, 1989).…”

mentioning

confidence: 99%

A New Fluorescence Reaction in DNA Cytochemistry: Microscopic and Spectroscopic Studies on the Aromatic Diamidino Compound M&B 938

Stockert

Trigoso

Cuéllar

et al. 1997

J Histochem Cytochem.

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We describe the fluorescence properties and cytochemical applications of the aromatic diamidine M&B 938. Treatment of cell smears (chicken blood, Ehrlich ascites tumor, rat bone marrow, mouse mast cells, and Trypanosoma cruzi epimastigotes) with aqueous solutions of M&B 938 (0.5-1 microgram/ml at pH 6-7; UV excitation) induced bright bluish-white fluorescence in DNA-containing structures (interphase and mitotic chromatin, AT-rich kinetoplast DNA of T. cruzi), which was abolished by previous DNA extraction. DNA was the unique fluorescent polyanion after staining with M&B 938 at neutral or alkaline pH, other polyanions such as RNA and heparin showing no emission. M&B 938-stained mouse metaphase chromosomes revealed high fluorescence of the AT-rich centromeric heterochromatin, and strong emission of heterochromatin in human chromosomes 1, 9, 15, 16, and Y was found after distamycin A counterstaining. On agarose gel electrophoresis, M&B 938-stained DNA markers appeared as fluorescent bands. The 1.635-KBP fragment from DNA ladder revealed a higher emission value than that expected from linear regression analysis. Spectroscopic studies showed bathochromic and hyperchromic shifts in the absorption spectrum of M&B 938 complexed with DNA, as well as strong enhancement of fluorescence at 420 nm. In the presence of poly(dA)-poly(dT), the emission of M&B 938 was 4.25-fold higher than with DNA; no fluorescence was observed with poly(dG)-poly(dC). Experimental results and considerations of the chemical structure suggest that the minor groove of AT regions of DNA could be the specific binding site for M&B 938, which shows interesting properties and useful applications as a new DNA fluorochrome.

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*SECTION OF BIOLOGY**: PHARMACOLOGY AND THERAPEUTIC VALUE OF DIAMIDINE DERIVATIVES—PARTICULARLY OF 2‐HYDROXYSTILBAMIDINE†

Cited by 46 publications

References 8 publications

Modern treatment of the systemic fungus diseases

Modern treatment of the systemic fungus diseases

Sensitivity ofHartmannella(Acanthamoeba) to5-fluorocytosine, hydroxystilbamidine, and other substances

A New Fluorescence Reaction in DNA Cytochemistry: Microscopic and Spectroscopic Studies on the Aromatic Diamidino Compound M&B 938

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SECTION OF BIOLOGY*: PHARMACOLOGY AND THERAPEUTIC VALUE OF DIAMIDINE DERIVATIVES—PARTICULARLY OF 2‐HYDROXYSTILBAMIDINE†

Cited by 46 publications

References 8 publications

Modern treatment of the systemic fungus diseases

Modern treatment of the systemic fungus diseases

Sensitivity ofHartmannella(Acanthamoeba) to5-fluorocytosine, hydroxystilbamidine, and other substances

A New Fluorescence Reaction in DNA Cytochemistry: Microscopic and Spectroscopic Studies on the Aromatic Diamidino Compound M&B 938

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Product

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*SECTION OF BIOLOGY**: PHARMACOLOGY AND THERAPEUTIC VALUE OF DIAMIDINE DERIVATIVES—PARTICULARLY OF 2‐HYDROXYSTILBAMIDINE†