Se-Pair Search for Deciphering Selenium-Encoded Peptide and a Pyrolysis-Thermolysis Dietary Model for Minimizing Loss of “KKSe(M)R” during Processing
Xin Wang,
Wei Jia
Abstract:Dietary
deficiency of selenium is a global health hazard. Supplementation
of organic selenopeptides via food crops is a relatively safe approach.
Selenopeptides with heterogeneous selenium-encoded isotopes or a poorly
fragmented peptide backbone remain unidentified in site-specific selenoproteomic
analysis. Herein, we developed the Se-Pair Search, a UniProtKB-FASTA-independent peptide-matching
strategy, exploiting the fragmentation patterns of shared peptide
backbones in selenopeptides to optimize spectral int… Show more
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