S inibacillus

Abstract

Si.ni.ba.cil'lus. N.L. fem. pl. n. Sinae China; L. dim. n. bacillus , a small rod; N.L. masc. n. Sinibacillus a rod‐shaped microbe isolated from China. Firmicutes / Bacilli / Bacillales / Bacillaceae / Sinibacillus Cells are Gram‐positive, facultatively anaerobic, motile, and endospore‐forming rods that occur singly or in short chains. Colonies are small, circular, and convex with regular margin. Growth occurs in the temperature range 30–63°C, within a narrow pH range (7.0–9.0), and with NaCl concentrations of 0.5–6% (w/v). The cell wall peptidoglycan type is A1 γ ( meso ‐DAP direct). Cellular fatty acids consist mainly of iso‐ and anteiso‐branched acids with anteiso‐C 15:0 predominating. The major respiratory quinone is MK‐7. Polar lipids mainly consist of diphosphatidylglycerol and phosphatidylglycerol. Phylogenetically related to the genera Pseudogracilibacillus , Ornithinibacillus , Virgibacillus , Oceanobacillus , and other genera of the family Bacillaceae. The members of the genus exhibiting low 16S rRNA gene sequence similarity to the nearest species Ornithinibacillus contaminans (94.9%) and Pseudogracilibacillus marinus (94.6%). Members of the class Bacilli, family Bacillaceae. Known habitats are tropical forest soil and hot spring sediment. DNA G + C content (mol%) : 43.7–44.1 (HPLC). Type species : Sinibacillus soli Yang and Zhou 2014, 1651 VP .

Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node

“…However, there were differences in subcellular localization in different tissues and developmental stages of adult mice (Tanno et al, 2007). And existing data suggest that its subcellular localization can be altered by two nuclear localization signals (NLSs) and two nuclear export signals (NESs) which are located on the protein's amino acid sequences (Yang T. et al, 2019). Under normal physiological conditions, the activity and expression of SIRT1 are simultaneously regulated by multiple mechanisms and maintained at a normal level to adapt to environmental stress.…”