<i><scp>RAGE</scp></i> polymorphisms and oxidative stress levels in <scp>H</scp>ashimoto's thyroiditis

Giannakou, Maria E.; Saltiki, Katerina; Mantzou, Emily; Loukari, Eleni; Philippou, Georgios; Terzidis, Konstantinos; Lili, Kiriaki; Stavrianos, Charalampos; Kyprianou, Miltiades; Alevizaki, Maria

doi:10.1111/eci.12739

Cited by 15 publications

(14 citation statements)

References 40 publications

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“…Studies in euthyroid patient with HT showed that the oxidative balance in these patients is shifted toward the oxidant side ( 20 , 21 , 22 ). Also, there are few studies that showed an association between high oxidative stress and the progression of HT ( 23 , 34 , 35 ). In the same direction, the present finding showed that women with HT who were in need of thyroxine replacement therapy to be euthyroid had higher oxidative stress levels compared to those who were euthyroid without therapy.…”

Section: Discussionmentioning

confidence: 99%

“…The PerOx-(TOS/TOC) kit defines TOS values <180 μmol/L as low oxidative stress, TOS values 180–310 μmol/L as moderate oxidative stress and TOS values >310 μmol/L as high oxidative stress. In a previous study using the PerOx-(TOS/TOC) kit in the same population, it was shown that TOS had significant ability to discriminate between the two HT groups ( 35 ). Further analysis showed that the cutoff value that offered the best tradeoff between sensitivity and specificity was 590 μmol/L ( 35 ).…”

Section: Methodsmentioning

confidence: 99%

“…In a previous study using the PerOx-(TOS/TOC) kit in the same population, it was shown that TOS had significant ability to discriminate between the two HT groups ( 35 ). Further analysis showed that the cutoff value that offered the best tradeoff between sensitivity and specificity was 590 μmol/L ( 35 ). Based on these results, TOS values for the present study were recoded as ‘high TOS’ (≥590 μmol/L) vs ‘medium/low TOS’ (<590 μmol/L).…”

Section: Methodsmentioning

confidence: 99%

“…Studies evaluating the effect of thyroxine replacement therapy in newly diagnosed hypothyroid HT patients showed an improvement in the oxidative status of these patients when they became euthyroid ( 32 , 33 ). Recent studies showed that high oxidative stress is associated with the severity and the progression of HT from euthyroidism to overt hypothyroidism ( 23 , 34 , 35 ). The aim of the present study was to investigate whether high oxidative stress is further influenced by obesity and dietary habits in euthyroid women with Hashimoto thyroiditis.…”

Section: Introductionmentioning

confidence: 99%

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The effect of obesity and dietary habits on oxidative stress in Hashimoto’s thyroiditis

Giannakou

Saltiki

Mantzou³

et al. 2018

Endocrine Connections

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ObjectiveIncreased oxidative stress has been described in patients with Hashimoto’s thyroiditis (HT). The aim of the present study was to investigate whether high oxidative stress is further influenced by obesity and dietary habits in euthyroid women with HT.MethodsTwo hundred eighteen consecutive euthyroid women with HT were studied and separated in two groups; 102 with thyroxine replacement and 114 without. For the evaluation of oxidative stress, total lipid peroxide levels in serum (TOS) were measured and recoded as ‘high TOS’ vs ‘medium/low TOS’. The type of food and consumption frequency were recorded. Two binary variables were considered; normal vs low fruit consumption and daily vs sporadic vegetable consumption.Results‘High TOS’ was more frequent in women under thyroxine replacement (31.4% vs 14.7%, OR = 2.7, 95% CI: 1.4–5.2). The prevalence of ‘high TOS’ was higher among overweight/obese women compared to women with normal BMI (30.4% vs 12.5%, OR = 3.1, 95% CI: 1.5–6.4). Low fruit consumption was associated with increased ‘high TOS’ prevalence (30.6% vs 12.9%, OR = 3.0, 95% CI: 1.4–6.2). Sporadic vegetable consumption was associated with increased ‘high TOS’ prevalence compared to daily consumption (29.9% vs 13.5%, OR = 2.7, 95% CI: 1.3–5.7). The examined risk factors were independent and additive in their effect on TOS. At least three risk factors had to be concomitantly present for the likelihood of ‘high TOS’ to be significantly elevated.ConclusionsOxidative stress is increased in women with HT under thyroxine replacement. Nevertheless, normal BMI, daily fruit and vegetable consumption, all contribute in maintaining oxidative stress at low levels.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effect of obesity and dietary habits on oxidative stress in Hashimoto’s thyroiditis

Giannakou

Saltiki

Mantzou³

et al. 2018

Endocrine Connections

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“…Oxidative stress is associated with the progression of Hashimoto's disease [28,36], while in patients with improved thyroid function, a simultaneous improvement of the antioxidant potential was observed. Examining the impact of diet on changes in the oxidation and reduction potential of the body, expressed in the total number of peroxides in plasma, a relationship between the consumption of vegetables and fruit in the diet and the amount of oxidative damage measured in the blood was established.…”

Section: Factors Connected With Ethiopatogenesis Of Hashimoto's Diseasementioning

confidence: 99%

The importance of nutritional factors and dietary management of Hashimoto’s thyroiditis

Ihnatowicz¹,

Drywień²,

Wątor³

et al. 2020

Ann Agric Environ Med.

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Hashimoto (HT) is an autoimmune disease in which destruction of the thyroid occurs as a result of lymphocyte infiltration. It is caused by an increased level of titers of antibody against thyroid peroxidase (TPO) and thyroglobulin (TG). Because of that,in HT patients, changes are observed in the level and metabolism of thyroid hormones, which leads to unspecified physical and psychological symptoms. A high level of antibodies attacking thyroid antigens has been positively correlated with the symptoms. From the etiological point of view, the most important are genetic factors; however, environmental factors are necessary to provoke the immune system to attack until the process is over. Scientists indicate specified stress, toxification, microbiota dysbiosis and under-or over-nutrition, to name only a few. Dietotherapy of Hashimoto's is based on the proper nourishment of the body and regulation of the immune system by an anti-inflammatory diet. Observational and controlled trials have shown frequent nutrition deficiencies in HT patients. In literature, there is evidence for selenium, potassium, iodine, copper, magnesium, zinc, iron, vitamin A, C, D and B. The role of the proper level of protein intake, dietary fibre and unsaturated fatty acids, especially the n-3 family, has been indicated. HT patients should often eliminate lactose because of intolerance and interactions with levothyroxine and gluten because of possible interactions of gliadin with thyroid antigens. The article describes the nutrition factors of HT patients, and share nutrition recommendations for diet therapy.

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Real-time oxidative stress biomarkers measured in patients with Hashimoto’s thyroiditis—an electron paramagnetic resonance study

et al. 2019

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RAGE polymorphisms and oxidative stress levels in Hashimoto's thyroiditis

Abstract: Our findings indicate that both examined risk factors may be implicated in the occurrence of Hashimoto's thyroiditis, but this covers only a fraction of the pathophysiology of the disease.

Cited by 15 publications

References 40 publications

The effect of obesity and dietary habits on oxidative stress in Hashimoto’s thyroiditis

The effect of obesity and dietary habits on oxidative stress in Hashimoto’s thyroiditis

The importance of nutritional factors and dietary management of Hashimoto’s thyroiditis

Real-time oxidative stress biomarkers measured in patients with Hashimoto’s thyroiditis—an electron paramagnetic resonance study

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