<i><scp>PRLH</scp></i> and <i><scp>SOD</scp>1</i> gene variations associated with heat tolerance in Chinese cattle

Zeng, Lulan; Chen, N.; Ning, Qingqing; Yao, Yufei; Chen, H.; Dang, Ruihua; Zhang, H.; Lei, Chuzhao

doi:10.1111/age.12702

Cited by 22 publications

(11 citation statements)

References 27 publications

(20 reference statements)

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“…T and RH over the last 30 years of sampling site of 32 cattle breeds were collected from the Chinese Central Meteorological Office (Supplementary, Table S1) () [22].…”

Section: Methodsmentioning

confidence: 99%

A Missense Mutation of the HSPB7 Gene Associated with Heat Tolerance in Chinese Indicine Cattle

Zeng

Cao

et al. 2019

Animals

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The small heat shock proteins (HSPB) are expressed in response to heat stress, and the heat shock protein family B (small) member 7 (HSPB7) gene has been reported to play an important role in heat tolerance pathways. Only a missense mutation (NC_037329.1: g.136054902 C > G: p.Ala69Gly) was identified in the HSPB7 gene in indicine cattle, which might be a candidate mutation associated with the heat tolerance. Here, we explore the allele frequency of this mutation in 774 individuals belonging to 32 Chinese indigenous cattle breeds using polymerase chain reaction (PCR) and DNA sequencing methods. The distribution of alleles of NC_037329.1: g.136054902 C > G displays significant geographical difference across native Chinese cattle breeds that the allele C was dominant in northern cattle groups, while allele G was dominant in southern indicine cattle groups. Additionally, the association analysis indicated that the G allele was significantly associated with mean annual temperature (T), relative humidity (RH), and temperature humidity index (THI) (p < 0.01), suggesting that cattle carrying allele G were distributed in regions with higher T, RH, and THI. Our results demonstrate that the mutation of the HSPB7 gene in Chinese indicine cattle might be a candidate gene associated with the heat tolerance.

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“…T and RH over the last 30 years of sampling site of 32 cattle breeds were collected from the Chinese Central Meteorological Office (Supplementary, Table S1) () [22].…”

Section: Methodsmentioning

confidence: 99%

A Missense Mutation of the HSPB7 Gene Associated with Heat Tolerance in Chinese Indicine Cattle

Zeng

Cao

et al. 2019

Animals

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“…The frequency of Chinese indicine cattle progressively decreases from south to north [22]. Additionally, China has tropical, subtropical, temperate, and cold regions that provide a geographic basis for SNPs variation [23], which make Chinese cattle suitable for the selection of heat-tolerant SNPs.…”

Section: Introductionmentioning

confidence: 99%

Association of HSF1 Genetic Variation with Heat Tolerance in Chinese Cattle

Rao

Zeng

Guan

et al. 2019

Animals

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The heat shock factor 1 (HSF1) gene is a regulator of the heat stress response, maximizing HSP protein expression survival. In this research, we explored the frequency distribution of a missense mutation (NC_037341.1 g.616087A > G, rs135258919) in the HSF1 gene in Chinese cattle with amino acid substitution, valine to alanine. This mutation could be related to the heat tolerance in Bos indicus. A total of 941 individuals representing 35 Chinese native cattle breeds, combining pure taurine (Angus) and indicine cattle, were used to determine the genotypes of the mutation through PCR and partial DNA sequencing. The results showed significant differences in allele frequencies and their genotypes amongst Chinese cattle from different regions. Allele G or indicine-specific allele frequency diminished from south to north China, while allele A (genotype AA) or the taurine-specific allele had a contrary pattern, which agreed with the distribution of taurine and indicine cattle. According to the association analysis, the NC_037341.1 g.616087A > G (rs135258919) of the bovine HSF1 gene, annual temperature (T), relative humidity (RH), and the temperature humidity index (THI) (p < 0.01) were interrelated closely, which indicated that the NC_037341.1 g.616087A > G of the HSF1 gene is associated with heat tolerance in indicine cattle.

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“…Guangxi Zhuang Autonomous Region undergoes characteristic subtropical monsoon climate with hot and humid summers and dry and mild winters, which provides an environment for the spread of disease. Although the temperature and humidity are significantly higher than the Yangtze region [3], the native FZ buffalo is with high disease resistance. Our results provided the genetic evidence to illustrate the capability of the local buffalo adaptation to the local environment bearing enhanced disease resistance.…”

Section: Discussionmentioning

confidence: 97%

“…In particular, the buffalo distributed in Upper Yangtze exhibited weak gene flow from the Southeast Asian buffalo [ 2 ]. The Fuzhong (FZ) buffalo is a native livestock from Guangxi Zhuang Autonomous Region, one of the hottest and most humid region in the Southwest of China [ 3 ]. Except for its use as a draft animal like other swamp buffaloes, the FZ buffalo has also been used in bullfighting as a folk custom with long history in Guangxi Zhuang Autonomous Region [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Selection signatures of Fuzhong Buffalo based on whole-genome sequences

et al. 2020

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Background Fuzhong buffalo, a native breed of Guangxi Zhuang Autonomous Region, is traditionally used as a draft animal to provide farm power in the rice cultivation. In addition, the Fuzhong buffalo also prepared for the bullfighting festival organized by the locals. The detection of the selective signatures in its genome can help in elucidating the selection mechanisms in its stamina and muscle development of a draft animal. Results In this study, we analyzed 27 whole genomes of buffalo (including 15 Fuzhong buffalo genomes and 12 published buffalo genomes from Upper Yangtze region). The ZHp, ZFst, π-Ratio, and XP-EHH statistics were used to identify the candidate signatures of positive selection in Fuzhong buffalo. Our results detected a set of candidate genes involving in the pathways and GO terms associated with the response to exercise (e.g., ALDOA, STAT3, AKT2, EIF4E2, CACNA2D2, TCF4, CDH2), immunity (e.g., PTPN22, NKX2-3, PIK3R1, ITK, TMEM173), nervous system (e.g., PTPN21, ROBO1, HOMER1, MAGI2, SLC1A3, NRG3, SNAP47, CTNNA2, ADGRL3). In addition, we also identified several genes related to production and growth traits (e.g., PHLPP1, PRKN, MACF1, UCN3, RALGAPA1, PHKB, PKD1L). Our results depicted several pathways, GO terms, and candidate genes to be associated with response to exercise, immunity, nervous system, and growth traits. Conclusions The selective sweep analysis of the Fuzhong buffalo demonstrated positive selection pressure on potential target genes involved in behavior, immunity, and growth traits, etc. Our findings provided a valuable resource for future research on buffalo breeding and an insight into the mechanisms of artificial selection.

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PRLH and SOD1 gene variations associated with heat tolerance in Chinese cattle

Cited by 22 publications

References 27 publications

A Missense Mutation of the HSPB7 Gene Associated with Heat Tolerance in Chinese Indicine Cattle

A Missense Mutation of the HSPB7 Gene Associated with Heat Tolerance in Chinese Indicine Cattle

Association of HSF1 Genetic Variation with Heat Tolerance in Chinese Cattle

Selection signatures of Fuzhong Buffalo based on whole-genome sequences

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