<i><scp>P</scp>urpureocillium lilacinum</i> tattoo‐related skin infection in a kidney transplant recipient

Trinh, Sonya; Angarone, Michael

doi:10.1111/tid.12689

Cited by 26 publications

(30 citation statements)

References 11 publications

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“…Most clinical manifestations are associated with ocular and cutaneous/subcutaneous infections as described by Borba and Brito [9,63,64,65,66,67,68,69,70,71,72,73,74]. More recently, an onychomycosis [75] and a rare case of nasal perforation [76] were published.…”

Section: Pathogenic Paecilomyces Sppmentioning

confidence: 99%

Human Pathogenic Paecilomyces from Food

2018

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Paecilomyces spp. and Byssochlamys spp. are heat-resistant fungi important to industry because they can cause food and beverage spoilage, incurring economic loss. The consequences of food or beverage fungal colonization is the loss of nutritional value, structure and taste, and the possibility of producing toxic secondary metabolites that may result in medical problems. Furthermore, these fungi can infect animals and humans and it is unknown if contaminated foods may be fomites. P. variotii is the principal agent of food spoilage or contamination and it is most frequently associated with human hyalohyphomycosis with clinical manifestations including peritonitis, cutaneous and disseminated infections, among others. Byssochlamys spp. had not been identified as a cause of systemic infection until the case of a dog with a fungal infection, after immunosuppressive therapy. P. variotii has clinical importance because it causes severe infection in immunosuppressed patients and also because the number of immunocompetent infected patients is increasing. This review draws attention to the ability of these species to grow at high temperatures, to colonize food products, and to cause human disease.

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Section: Pathogenic Paecilomyces Sppmentioning

confidence: 99%

Human Pathogenic Paecilomyces from Food

2018

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“…We are aware of very few cases of cutaneous infection by this fungus reported in the literature and, to our knowledge, these are the only images with black papules. According to Saghrouni et al, successful cure has been achieved with griseofulvin, itraconazole, ketoconazole, and voriconazole in other cases 2,3. Voriconazole was initiated for this patient; however, he was lost to follow-up.…”

Section: Discussionmentioning

confidence: 88%

Atypical Fungal Rash

Adel

Bellamkonda

2019

Clinical Practice and Cases in Emergency Medicine

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“…Such highly PHMB-resistant P. lilacinum strains can spoil and contaminate numerous PHMB-containing products, such as medical supplies, cosmetics, and household products, as well as production lines and public places (e.g., pools and bathing houses) where PHMB is used for decontamination. PHMB is also a preservative in solutions for contact lenses; thus, the resistant strains increase the risk of infections, particularly endophthalmitis [29], keratitis [33], and skin infection [34]. Nevertheless, our ndings have considerable implications for microbial control.…”

Section: Discussionmentioning

confidence: 91%

Isolation and characterization of the polyhexamethylene biguanide hydrochloride-resistant fungus, Purpureocillium lilacinum

Yamamoto

Takahashi

Alimu

et al. 2020

Preprint

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Polyhexamethylene biguanide hydrochloride (PHMB), an antimicrobial agent, has been widely used as a disinfectant in medical industries and public facilities. However, long-term use of any antimicrobial agent increases the risk of the microorganisms developing resistance. We aimed to examine the presence of microorganisms highly resistant to PHMB to address potential medical safety and public health concerns and devise strategies to prevent resistance development. We isolated and characterized a fungus from a 20% aqueous solution of PHMB and compared its microbiological characteristics and resistance profile with those of other major antimicrobial agents. Additionally, we sequenced the genome of the isolate to predict PHMB resistance-related genes. Based on the internal transcribed spacer (ITS) region of ribosomal DNA, the fungus was identified as Purpureocillium lilacinum. Although the P. lilacinum type and resistant strains showed similar morphology, the latter had extremely low PHMB susceptibility and was able to grow in the 20% aqueous solution of PHMB, which killed the type strain. Additionally, the minimum inhibitory concentration (MIC) of PHMB against the resistant strain was approximately four times higher than that against the type strain. In contrast, the MICs of four other antimicrobial agents and seven antifungal agents against the resistant strain were either less than or equal to those against the type strain. Furthermore, MICs of PHMB against four pathogenic filamentous fungi and two yeasts were significantly lower than those against the resistant strain. Despite its specific high resistance to PHMB, no gene homologous to fungal PHMB-resistant gene was found in the genome of the resistant strain. In summary, P. lilacinum was found to be significantly more resistant to PHMB than previously reported, suggesting an unidentified novel mechanism underlying drug resistance in the fungi.

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Purpureocillium lilacinum tattoo‐related skin infection in a kidney transplant recipient

Cited by 26 publications

References 11 publications

Human Pathogenic Paecilomyces from Food

Human Pathogenic Paecilomyces from Food

Atypical Fungal Rash

Isolation and characterization of the polyhexamethylene biguanide hydrochloride-resistant fungus, Purpureocillium lilacinum

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