NLRP3 gene polymorphisms in Iranian patients with recurrent aphthous stomatitis

Abstract

Considering the high frequency of the presence of NLRP3 rs3806265 TT genotype in patients with RAS, it seems that this gene polymorphism could affect individual susceptibility to RAS.

Association of the NOD‐like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population

“…Alterations in the NLRP3 gene have been associated with different multifactorial diseases with inflammatory background and the presence of oral ulcers as one of the symptoms, such as Behçet's disease (BD), Crohn's disease, and celiac disease . Recent case‐control study in Iranian population suggested that single nucleotide polymorphism (SNP) NLRP3 rs3806265 might affect RAS development . The aim of our study was to investigate distribution of three NLRP3 SNPs (rs3806265, rs4612666, rs10754558) and their influence on RAS susceptibility in the Czech population.…”

“…The NLRP3 gene variability has recently been identified as a susceptibility factor for RAS in the Iranian population . In agreement with the results of this study, we did not observe correlation between SNP NLRP3 rs10754558 and RAS, even though this variant seems to influence NLRP3 mRNA stability .…”

Association of nod‐like receptor protein‐3 single nucleotide gene polymorphisms and expression with the susceptibility to relapsing–remitting multiple sclerosis

“…We did not detect any association between polymorphism of NLRP3 at position rs4612666 and rs35829419 with MS. In this regard, some studies also have shown no association between these polymorphisms and inflammatory diseases (Bidoki, et al, ; Deng et al, ), although Roberts et al ( reported association between NLRP3 rs35829419 SNP and Crohn's disease. On the other hand, we found decreased frequency of CCCC and TGTC and increased frequency of TCTC and TCCC haplotypes in MS patients.…”

“…About 60 single nucleotide polymorphisms (SNPs) have been recognized within the gene encoding protein of the NLRP3 (Zhang et al, ).The most identified polymorphisms within NLRP3 gene are rs10754558, rs12065526, rs4612666, rs4925648, rs10925019, rs10925027, rs3806265 and rs35829419. These gene polymorphisms have been shown to affect immune cell responses in a number of diseases, such as HIV (Pontillo et al, ), diabetes mellitus (Klen, Goričar, Janež, & Dolžan, ), recurrent aphthous stomatitis (RAS) (Bidoki et al, ) and Crohn's disease (Villani et al, ). Recently, Malhotra et al observed higher frequency of the NLRP3 rs35829419*A allele in IFNβ responder RRMS patients (Malhotra, et al, ).…”

The association of NLRP3 and TNFRSF1A polymorphisms with risk of ankylosing spondylitis and treatment efficacy of etanercept

“…Our study also illustrated that the NLRP3 rs3806265 in AS patients was overexpressed. We thus hypothesized that it could affect NLRP3 synthesis and culminated to the overproduction of IL‐1b (a cytokine involved in the development of AS) . The previous studies reported that the NLRP3 rs10925019 was associated with Crohn's and ulcerative colitis disease.…”