Lactobacillus in Jelly Enhances the Effect of Influenza Vaccination in Elderly Individuals

Effect of probiotics and prebiotics on immune response to influenza vaccination in adults: A systematic review and meta-analysis of randomized controlled trials

“…Meta-analysis was performed using Review Manager (RevMan) [ Figure 1 shows the search process and outcomes. A total of 19 publications with 20 RCTs were included for our systematic review [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]. Two trials (a pilot and a confirmatory study) with different patient numbers, treatment protocols, and years of study were published together [35].…”

“…Two trials (a pilot and a confirmatory study) with different patient numbers, treatment protocols, and years of study were published together [35]. Thirteen trials focused on probiotics [22,[26][27][28][29][30][31][32][33][34][35][36], while the other six RCTs focused on prebiotics [23][24][25][37][38][39]. Only one study concentrated on synbiotics [21].…”

“…These studies were conducted worldwide, with six trials in Japan [22][23][24]27,28,33], three trials in the USA [32,37,38], two studies each in Spain [31,36] and the UK [21,25], one publication in France [35], and one trial each in Australia [34], Belgium [29], Italy [30], Germany and Denmark [26], and Chile [39]. Seven RCTs enrolled healthy adults or older adults [21,25,26,30,32,34,36], and two trials enrolled healthy older adults [38,39].…”

“…Seven RCTs enrolled healthy adults or older adults [21,25,26,30,32,34,36], and two trials enrolled healthy older adults [38,39]. In another eleven trials, subjects living in hospitals, nursing homes, or long-term care facilities were enrolled [22][23][24][27][28][29]31,33,35,37]. Participants fed by enteral tube or percutaneous endoscopic gastrostomy were enrolled in three studies conducted in Japan [23,24,27].…”

Probiotics and Bacterial Immunomodulators for Prevention of Respiratory Infections

“…Например, в двойном слепом плацебоконтролируемом исследова-нии, проведенном на 42 здоровых взрослых, было пока-зано, что прием Lactobacillus GG в течение 28 сут после вакцинации способствовал нарастанию более высоко-го титра защитных антител по сравнению с группой, получавшей только противогриппозную вакцину [10]. Аналогичные результаты продемонстрированы и другими исследователями [11][12][13][14].…”