<i><scp>E</scp>lizabethkingia</i> species sepsis after lung transplantation: case report and literature review

Ramanan, Poornima; Razonable, Raymund R.

doi:10.1111/tid.12146

Cited by 9 publications

(5 citation statements)

References 40 publications

(53 reference statements)

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“…First observed as a causative agent of neonatal meningitis by King (1959), Elizabethkingia infections can cause a variety of conditions including necrotizing fasciitis (Lee et al 2006), endophthalmitis (Young et al 2014), pneumonia (da Silva and Pereira 2013), and sepsis (Green et al 2008; Ramanan and Razonable 2013). Elizabethkingia infections are most commonly observed in immunocompromised patients, mechanically ventilated patients, and neonates, but have been reported to cause meningitis in an immunocompetent adult (Hayek et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Revisiting the taxonomy of the genus Elizabethkingia using whole-genome sequencing, optical mapping, and MALDI-TOF, along with proposal of three novel Elizabethkingia species: Elizabethkingia bruuniana sp. nov., Elizabethkingia ursingii sp. nov., and Elizabethkingia occulta sp. nov.

Nicholson

Gulvik

Whitney

et al. 2017

Antonie van Leeuwenhoek

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The genus Elizabethkingia is genetically heterogeneous, and the phenotypic similarities between recognized species pose challenges in correct identification of clinically derived isolates. In addition to the type species Elizabethkingia meningoseptica, and more recently proposed Elizabethkingia miricola, Elizabethkingia anophelis and Elizabethkingia endophytica, four genomospecies have long been recognized. By comparing historic DNA-DNA hybridization results with whole genome sequences, optical maps, and MALDI-TOF mass spectra on a large and diverse set of strains, we propose a comprehensive taxonomic revision of this genus. Genomospecies 1 and 2 contain the type strains E. anophelis and E. miricola, respectively. Genomospecies 3 and 4 are herein proposed as novel species named as Elizabethkingia bruuniana sp. nov. (type strain, G0146 = DSM 2975 = CCUG 69503 = CIP 111191) and Elizabethkingia ursingii sp. nov. (type strain, G4122 = DSM 2974 = CCUG 69496 = CIP 111192), respectively. Finally, the new species Elizabethkingia occulta sp. nov. (type strain G4070 = DSM 2976 = CCUG 69505 = CIP 111193), is proposed.

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Section: Introductionmentioning

confidence: 99%

Revisiting the taxonomy of the genus Elizabethkingia using whole-genome sequencing, optical mapping, and MALDI-TOF, along with proposal of three novel Elizabethkingia species: Elizabethkingia bruuniana sp. nov., Elizabethkingia ursingii sp. nov., and Elizabethkingia occulta sp. nov.

Nicholson

Gulvik

Whitney

et al. 2017

Antonie van Leeuwenhoek

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“…Patients infected with Elizabethkingia exhibited a high mortality rate of 34-60% (20). The immune status of patients and virulence factors of microorganisms may be associated with the high case-fatality rate of Elizabethkingia infections (21). Moreover, a number of previous studies have shown that patients with Elizabethkingia infections frequently had chronic illnesses (22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

Clinical manifestations, antimicrobial resistance and genomic feature analysis of the multi-drug resistance Elizabethkingia strains

Xiong

Liao

et al. 2023

Preprint

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Background Elizabethkingia are now emerging as an opportunistic pathogenic bacterium in human. The aim of this study is to investigate the clinical epidemiology, antimicrobial resistance, virulence factors, genome features, and comparative genomics of this pathogen. Methods Seven Elizabethkingia isolates were identified by MALDI-TOF MS, and antimicrobial susceptibility testing also was performed. They were conducted whole-genome sequencing (WGS) and compared with a global strain data set, including 83 Elizabethkingia whole-genomes sequences collected from NCBI database. Average nucleotide identity (ANI), pan-genome analysis, and KEGG analyses were performed, and orthologous groups were evaluated. Results A total of 71 Elizabethkingia strains were mainly obtained from the department of ICU (36.6%, 26/71) and emergency (32.4%, 23/71). The number of strains isolated from the respiratory tract specimens was the highest. The mean age of the infected patients was 56.9 years and 64.8% were male. All patients had a history of broad-spectrum antimicrobial exposure. Hospitalization for invasive mechanical ventilation or catheter insertion were found to be the risk factors for infection. Isolates displaced high susceptibility rate to levofloxacin, trimethoprim-sulfamethoxazole, and all were sensitive to minocycline. Genomics analysis revealed that five β-lactamase genes (blaGOB, blaB, blaCME, blaOXA, blaTEM) responsible for β-lactams resistance, seventeen virulence genes involve in stress adaption, adherence and immune modulation. The bulk of the core genomes in the Elizabethkingia genomes were associated with metabolism, according to a function study of the COGs, whereas the unique gene families were largely involved in "information storage and processing." The five type species of the Elizabethkingia genus were identified by pan-genome analysis to have a total of 2,077 clusters of orthologous groups. Conclusion The comparative analysis of the clinical data and associated genomes of patients infected with Elizabethkingia can provide a better understanding of this organism.

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“…infections, as antimicrobial susceptibilities have been inconsistent across reports. [8] Interestingly, E. meningoseptica is often susceptible to agents generally used to treat infections caused by Gram-positive bacteria, such as rifampicin, clindamycin, erythromycin, trimethoprimsulfamethoxazole, quinolones, and vancomycin. Our patient's recognizable risk factors for E. meningoseptica are underlying hypocortisolism and prolonged intensive care and hospital stay.…”

Section: Discussionmentioning

confidence: 99%

Nosocomial Elizabethkingia meningoseptica meningitis and bacteremia in a post transsphenoidal hypophysectomy complicated with sagittal sinus thrombosis: A case report

Balakrishnan

Ghani

Hassan

et al. 2022

Surgical Neurology International

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Background: Elizabethkingia meningoseptica meningitis is rare and challenging to manage infection. As this infection is always associated with superimposed multidrug-resistant organisms, a combination and prolonged antibiotic treatment are necessary to ensure the complete eradication of infections. Case Description: We report successful antibiotic therapies in a patient with E. meningoseptica bacteremia and meningitis complicated with superimposed extreme-drug-resistant Acinetobacter baumannii infection in a patient post transsphenoidal hypophysectomy complicated with central venous thrombosis. Conclusion: Antibiotic combination therapy with prolonged duration in those with E. meningoseptica with concomitant multi-resistant organisms is needed. Diagnosing associated prothrombotic risk with the infection and prompt treatment would also be essential.

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Elizabethkingia species sepsis after lung transplantation: case report and literature review

Cited by 9 publications

References 40 publications

Revisiting the taxonomy of the genus Elizabethkingia using whole-genome sequencing, optical mapping, and MALDI-TOF, along with proposal of three novel Elizabethkingia species: Elizabethkingia bruuniana sp. nov., Elizabethkingia ursingii sp. nov., and Elizabethkingia occulta sp. nov.

Revisiting the taxonomy of the genus Elizabethkingia using whole-genome sequencing, optical mapping, and MALDI-TOF, along with proposal of three novel Elizabethkingia species: Elizabethkingia bruuniana sp. nov., Elizabethkingia ursingii sp. nov., and Elizabethkingia occulta sp. nov.

Clinical manifestations, antimicrobial resistance and genomic feature analysis of the multi-drug resistance Elizabethkingia strains

Nosocomial Elizabethkingia meningoseptica meningitis and bacteremia in a post transsphenoidal hypophysectomy complicated with sagittal sinus thrombosis: A case report

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