<i><scp>ALDH</scp>2</i> gene G487A polymorphism and coronary artery disease: a meta‐analysis including 5644 participants

Li, Yanyan; Wang, Hui; Wu, Jingjing; Kim, Hyun Jun; Yang, Xinxing; Geng, Hong‐yu; Gong, Ge

doi:10.1111/jcmm.13443

Cited by 18 publications

(16 citation statements)

References 31 publications

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“…These lend some support to our hypothesis concerning greater susceptibility to CVD-related conditions associated with ALDH2*2. Broadly, these findings are consistent with Asian studies that found increased risks associated with ALDH2*2 for CVD (Jo et al, 2007;Li et al, 2018), diabetes (Li et al, 2017;Yin et al, 2016), hypertension (Jia et al, 2015), and low-density lipoprotein cholesterol (Kotani et al, 2012). Though most of these studies did not consider drinking, interactions between alcohol consumption and ALDH genotypes have also been reported in a small number of studies.…”

Section: Discussionsupporting

confidence: 83%

Alcohol Consumption, Cardiovascular‐Related Conditions, and ALDH22* Ethnic Group Prevalence in Asian Americans

Cook

Tam

Luczak

et al. 2021

Alcoholism Clin & Exp Res

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Background Little is known about the relationships between alcohol consumption and cardiovascular disease (CVD) and related chronic conditions in Asian Americans and how such risk relationships vary among their subgroups. We examine these relationships in Asian Americans and their moderation by ethnic prevalence of a variant the aldehyde dehydrogenase gene: ALDH2*2. Methods Multiple logistic regression modeling was performed using a nationally representative sample of Asian‐American adults aged 30 to 70 (n = 1,720) from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) Waves 2 (2004 to 2005) and 3 (2012 to 2013). Outcomes considered were diabetes, hypertension, high cholesterol, CVD, any of the 3 conditions (i.e., diabetes, high cholesterol, and CVD) documented to have a J‐shaped relationship with drinking (CVDRC3), and any of the CVD‐related conditions (ANYCVD). Demographic and socioeconomic characteristics, health insurance coverage, and other lifestyle risk factors (smoking and obesity/overweight) were adjusted. Analyses were stratified by gender. Results Alcohol consumption level was positively associated only with hypertension in Asian males, with consuming 7 to 14 drinks per week associated with more than double the risk of lifetime abstinence. For females, alcohol consumption had a dose–response relationship with high cholesterol and CVDRC3. Membership in the higher ALDH2*2 ethnic group overall was associated with lower risk of CVD‐related conditions. However, compared to abstainers in lower ALDH2*2 group, females in the higher ALDH2*2 group who consumed more than 7 drinks per week had a higher risk of diabetes, hypertension, CVDRC3, and ANYCVD. Conclusions Asian Americans may have increased risk of CVD‐related conditions at relatively low alcohol consumption levels. Among Asian‐American females, in particular, any amount of drinking may increase risk for high cholesterol or any of the CVD‐related conditions previously documented to have a curvilinear relationship with drinking. These risks may be particularly elevated for those in ethnic groups with a high prevalence of ALDH2*2.

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Section: Discussionsupporting

confidence: 83%

Alcohol Consumption, Cardiovascular‐Related Conditions, and ALDH22* Ethnic Group Prevalence in Asian Americans

Cook

Tam

Luczak

et al. 2021

Alcoholism Clin & Exp Res

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“…The mutant genotypes and allele frequencies of rs671 are markedly different among different populations and are particularly more prevalent in East Asian populations (Chinese, Japanese and Korean individuals) than in other populations (38, 39). Many studies have demonstrated that the ALDH2 rs671 G>A polymorphism maybe associated with the development of various diseases, such as digestive system cancer (40), diabetes (41), coronary heart disease (42), and ischemic stroke (43), especially in East Asians.…”

Section: Discussionmentioning

confidence: 99%

Association Between Aldehyde dehydrogenase-2 Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 Individuals

et al. 2019

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Objective: A number of studies have reported that aldehyde dehydrogenase-2 ( ALDH2 ) polymorphisms maybe associated with the risk of Alzheimer's disease (AD) and Parkinson's disease (PD). However, the results of such studies are inconsistent. We therefore conducted a meta-analysis to clarify the association between ALDH2 polymorphisms and the risk of AD and PD. Methods: Five online databases were searched and the relevant studies were reviewed from inception through May 10, 2018. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated in each genetic model of the general population and various subgroups. Furthermore, we simultaneously performed heterogeneity, cumulative, sensitivity, and publication bias analyses. Results: Overall, nine case-control studies involving 5,315 subjects were included in this meta-analysis. Potential associations were found between the ALDH2 rs671 G>A polymorphism and the risk of AD (A vs. G: OR = 1.46, 95%CI = 1.01–2.11, P = 0.05, I 2 = 84.2%; AA vs. GG: OR = 2.22, 95%CI = 1.03–4.77, P = 0.04, I 2 = 79.2%; AA vs. GG+GA: OR = 1.94, 95%CI = 1.03–3.64, P =0.04, I 2 = 71.1%). In addition, some similar results were observed in other subgroups. Moreover, no significant association between ALDH2 polymorphisms and PD risk. Conclusions: In conclusion, our meta-analysis indicated that the ALDH2 rs671 G>A polymorphism plays an important role in AD development.

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“…The ALDH2*2 (rs671) variant is an independent risk factor of coronary heart disease in many population-based studies [164–168]. In 248 patients with coronary heart disease, the variant ALDH2 genotypes (GG & GA) were associated with increased serum levels of 4-HNE, severity of coronary artery stenosis and atherosclerosis [169].…”

Section: Therapies Targeting Mitochondria In Heart Failurementioning

confidence: 99%

Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities

Kiyuna

Albuquerque

Chen

et al. 2018

Free Radical Biology and Medicine

153

131

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Mitochondrial dysfunction characterized by impaired bioenergetics, oxidative stress and aldehydic load is a hallmark of heart failure. Recently, different research groups have provided evidence that selective activation of mitochondrial detoxifying systems that counteract excessive accumulation of ROS, RNS and reactive aldehydes is sufficient to stop cardiac degeneration upon chronic stress, such as heart failure. Therefore, pharmacological and non-pharmacological approaches targeting mitochondria detoxification may play a critical role in the prevention or treatment of heart failure. In this review we discuss the most recent findings on the central role of mitochondrial dysfunction, oxidative stress and aldehydic load in heart failure, highlighting the most recent preclinical and clinical studies using mitochondria-targeted molecules and exercise training as effective tools against heart failure.

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ALDH2 gene G487A polymorphism and coronary artery disease: a meta‐analysis including 5644 participants

Cited by 18 publications

References 31 publications

Alcohol Consumption, Cardiovascular‐Related Conditions, and ALDH22* Ethnic Group Prevalence in Asian Americans

Alcohol Consumption, Cardiovascular‐Related Conditions, and ALDH22* Ethnic Group Prevalence in Asian Americans

Association Between Aldehyde dehydrogenase-2 Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 Individuals

Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities

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ALDH2 gene G487A polymorphism and coronary artery disease: a meta‐analysis including 5644 participants

Cited by 18 publications

References 31 publications

Alcohol Consumption, Cardiovascular‐Related Conditions, and ALDH2*2 Ethnic Group Prevalence in Asian Americans

Alcohol Consumption, Cardiovascular‐Related Conditions, and ALDH2*2 Ethnic Group Prevalence in Asian Americans

Association Between Aldehyde dehydrogenase-2 Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 Individuals

Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities

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Alcohol Consumption, Cardiovascular‐Related Conditions, and ALDH22* Ethnic Group Prevalence in Asian Americans

Alcohol Consumption, Cardiovascular‐Related Conditions, and ALDH22* Ethnic Group Prevalence in Asian Americans