<i>Schistosoma haematobium</i>Infection and Morbidity Before and After Large‐Scale Administration of Praziquantel in Burkina Faso

Koukounari, Artemis; Gabrielli, Albis Francesco; Touré, Seydou; Bosqué-Oliva, Elisa; Zhang, Yaobi; Sellin, Bertrand; Donnelly, Christl A.; Fenwick, A; Webster, Joanne P.

doi:10.1086/520515

Cited by 143 publications

(122 citation statements)

References 29 publications

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“…47,48 This gap in the association with chronic parasitic infection is probably caused by the prolonged lag (time elapsed) between initial infection and its effect on linear growth and the detection of growth failure (HAZ −2), which takes months to years to become manifest. 37 Causality is, therefore, difficult to establish because of a multiplicity of potential confounders, particularly those confounders associated with poor diet, poverty, and low SES.…”

Section: Discussionmentioning

confidence: 99%

Impact of Polyparasitic Infections on Anemia and Undernutrition among Kenyan Children Living in a Schistosoma haematobium-Endemic Area

Bustinduy

Parraga

Thomas

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. We measured prevalence of Schistosoma haematobium, Wuchereria bancrofti, Plasmodium falciparum, hookworm, and other geohelminths among school-aged children in four endemic villages in Kwale County, Kenya and explored the relationship between multiparasite burden, undernutrition, and anemia. In 2009-2010 surveys, cross-sectional data were obtained for 2,030 children 5-18 years old. Infections were most prevalent for S. haematobium (25-62%), hookworm (11-28%), and falciparum malaria (8-24%). Over one-half of children were anemic, with high rates of acute and chronic malnutrition. Associations with infection status showed significant age and sex differences. For boys, young age, low socioeconomic standing (SES), S. haematobium, and/or malaria infections were associated with greater odds of anemia, wasting, and/or stunting; for girls, heavy S. haematobium infection and age were the significant cofactors for anemia, whereas low SES and older age were linked to stunting. The broad overlap of infection-related causes for anemia and malnutrition and the high frequency of polyparasitic infections suggest that there will be significant advantages to integrated parasite control in this area.

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Section: Discussionmentioning

confidence: 99%

Impact of Polyparasitic Infections on Anemia and Undernutrition among Kenyan Children Living in a Schistosoma haematobium-Endemic Area

Bustinduy

Parraga

Thomas

et al. 2013

The American Society of Tropical Medicine and Hygiene

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“…16 Currently, the WHO strategy for schistosomiasis control relies on mass-drug administration (MDA) of praziquantel, 17 which is effective in reducing disease-associated morbidity. [18][19][20][21][22] The impact of MDA is measured by a change in infection prevalence and intensity. Guidelines exist for schistosomiasis MDA thresholds, frequency, and target populations (school-based versus community-wide), but there are few objective data supporting them.…”

Section: Introductionmentioning

confidence: 99%

Schistosoma mansoni Morbidity among School-Aged Children: A SCORE Project in Kenya

Samuels

Matey²,

Mwinzi³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Schistosomiasis control programs aim to reduce morbidity but are evaluated by infection prevalence and intensity reduction. We present baseline cross-sectional data from a nested cohort study comparing indicators of morbidity for measuring program impact. Eight hundred twenty-two schoolchildren 7-8 years of age from Nyanza Province, Kenya, contributed stool for diagnosis of Schistosoma mansoni and soil-transmitted helminths (STH) and blood smears for malaria, and were evaluated for anemia, quality of life, exercise tolerance, anthropometry, and ultrasound abnormalities. Schistosoma mansoni, STH, and malaria infection prevalence were 69%, 25%, and 8%, respectively. Only anemia and S. mansoni infection (adjusted odds ratio [aOR] = 1.70; confidence interval [CI] = 1.03-2.80), and hepatomegaly and heavy S. mansoni infection (aOR = 2.21; CI = 1.19-4.11) were associated. Though anemia and hepatomegaly appeared most useful at baseline, additional morbidity indicators may be sensitive longitudinal measures to evaluate schistosomiasis program health impact.

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“…In highly endemic populations, micronutrients are being distributed as part of parasite control programmes to reduce the burden of anaemia. 2,[25][26][27][28][29][30][31] We have used data collected and georeferenced by the Demographic and Health Surveys (DHS), together with highresolution continental maps of selected environmental variables, Abstracts in ‫,عريب‬ 中文, Français, Pусский and Español at the end of each article.…”

Section: Introductionmentioning

confidence: 99%

Spatial heterogeneity of haemoglobin concentration in preschool-age children in sub-Saharan Africa

Magalhães

Clements

2011

Bull. World Health Organ.

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Schistosoma haematobiumInfection and Morbidity Before and After Large‐Scale Administration of Praziquantel in Burkina Faso

Abstract: This study suggests that even a single round of mass chemotherapy can have a substantial impact on S. haematobium infection and its associated morbidity in children.

Cited by 143 publications

References 29 publications

Impact of Polyparasitic Infections on Anemia and Undernutrition among Kenyan Children Living in a Schistosoma haematobium-Endemic Area

Impact of Polyparasitic Infections on Anemia and Undernutrition among Kenyan Children Living in a Schistosoma haematobium-Endemic Area

Schistosoma mansoni Morbidity among School-Aged Children: A SCORE Project in Kenya

Spatial heterogeneity of haemoglobin concentration in preschool-age children in sub-Saharan Africa

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