<i>Schisandra chinensis</i>
            essential oil attenuates acetaminophen-induced liver injury through alleviating oxidative stress and activating autophagy

Zhao, Jing; Ding, Kaixin; Hou, Manting; Li, Yuanhua; Hou, Xiaorong; Dai, Wei; Li, Zhiyong; Zhao, Jingbo; Liu, Wenlong; Bai, Zhaofang

doi:10.1080/13880209.2022.2067569

Cited by 7 publications

(2 citation statements)

References 46 publications

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“…Therefore, it is more effective in improving the inflammatory damage of NAFLD. Modern pharmacological studies showed that the extract of Schisandra chinensis could reduce liver damage and serum ALT, AST levels ( Zhao J et al, 2022 ). Liqustri lucidi Fructus could regulate AMPK signaling pathway to protect hepatocytes from oxidative damage ( Seo et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative efficacy of Chinese patent medicines for non-alcoholic fatty liver disease: A network meta-analysis

Zhang

Liu²,

Gu³

et al. 2023

Front. Pharmacol.

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Background: The incidence of Non-alcoholic fatty liver disease (NAFLD) is increasing year by year. Researches showed that Chinese patent medicines (CPMs) had achieved good efficacy in the treatment of Non-alcoholic fatty liver disease. However, the debate on optimum Chinese patent medicine (CPM) persists. Therefore, we conducted a network meta-analysis to objectively compare the efficacy of different Chinese patent medicines in the treatment of Non-alcoholic fatty liver disease.Methods: PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Database, China Science and Technology Journal Database, and Chinese Biomedical Literature Database were used as databases for RCT researches retrieval. The retrieval time was from establishment of the database to July 2022. After effective data was extracted, Review Manager 5.4 and Cochrane Collaboration System Evaluator’s Manual were used to assess bias risk. STATA 16.0 based on frequency theory was used for the network meta-analysis.Results: Totally 39 studies were included, involving 13 Chinese patent medicines, including 4049 patients, of which 42 patients were lost. In terms of improving clinical efficiency rate, Zhibitai capsule was most likely the best choice of Chinese patent medicine for Non-alcoholic fatty liver disease. Liuwei Wuling tablet had the best effect in reducing serum ALT and AST; Gandan Shukang capsule had the best effect in reducing serum GGT; Qianggan capsule had the best effect in reducing serum TG; Dangfei Liganning capsule had the best effect in reducing serum TC. None of the included studies had serious adverse reactions.Conclusion: For patients with Non-alcoholic fatty liver disease in this NMA, Zhibitai capsule, Liuwei Wuling tablet, Gandan Shukang capsule, Qianggan capsule, Dangfei Liganning capsule might be noteworthy. Due to the uclear risk bias, better designed double-blind, multi center and large sample RCTs are needed which resolve the problems of blinding, selective reporting and allocation concealment.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42022341240.

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Section: Discussionmentioning

confidence: 99%

Comparative efficacy of Chinese patent medicines for non-alcoholic fatty liver disease: A network meta-analysis

Zhang

Liu²,

Gu³

et al. 2023

Front. Pharmacol.

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“…Concerning anticancer effects, for example, the essential oil of Origanum montana inhibited colony growth of human HT-29 colorectal cancer cells by inducing protective autophagy, associated with downregulation of the mTOR/p70S6K pathway and apoptotic cells death, via the activation of the p38 MAPK signalling pathway [110]. In what concerns cell toxicity, the essential oil of Schisandra chinensis was able to attenuate acetaminophen-induced liver injury by alleviating oxidative stress and activating autophagy, showing an upregulation of hepatic LC3-II and a decrease in p62 in mice with an overdose of acetaminophen [111]. Moreover, the essential oil of Acorus tatarinowii ameliorated Aβ-induced toxicity in Caenorhabditis elegans by maintaining protein homeostasis through the autophagy pathway regulated partly by hsf-1 and sir-2.1 genes [112].…”

Section: Carvacrolmentioning

confidence: 99%

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

Zuzarte,

Sousa,

Alves-Silva

et al. 2024

Biomedicines

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Ageing is a natural process characterized by a time-dependent decline of physiological integrity that compromises functionality and inevitably leads to death. This decline is also quite relevant in major human pathologies, being a primary risk factor in neurodegenerative diseases, metabolic disorders, cardiovascular diseases and musculoskeletal disorders. Bearing this in mind, it is not surprising that research aiming at improving human health during this process has burst in the last decades. Importantly, major hallmarks of the ageing process and phenotype have been identified, this knowledge being quite relevant for future studies towards the identification of putative pharmaceutical targets, enabling the development of preventive/therapeutic strategies to improve health and longevity. In this context, aromatic plants have emerged as a source of potential bioactive volatile molecules, mainly monoterpenes, with many studies referring to their anti-ageing potential. Nevertheless, an integrated review on the current knowledge is lacking, with several research approaches studying isolated ageing hallmarks or referring to an overall anti-ageing effect, without depicting possible mechanisms of action. Herein, we aim to provide an updated systematization of the bioactive potential of volatile monoterpenes on recently proposed ageing hallmarks, and highlight the main mechanisms of action already identified, as well as possible chemical entity–activity relations. By gathering and categorizing the available scattered information, we also aim to identify important research gaps that could help pave the way for future research in the field.

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Fermented Syzygium samarangense leaves mitigate oxidative stress-triggered hepatotoxicity through Nrf2 activation and epigenetic regulation

Huang,

Lin,

et al. 2024

Food Bioscience

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Schisandra chinensis essential oil attenuates acetaminophen-induced liver injury through alleviating oxidative stress and activating autophagy

Cited by 7 publications

References 46 publications

Comparative efficacy of Chinese patent medicines for non-alcoholic fatty liver disease: A network meta-analysis

Comparative efficacy of Chinese patent medicines for non-alcoholic fatty liver disease: A network meta-analysis

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

Fermented Syzygium samarangense leaves mitigate oxidative stress-triggered hepatotoxicity through Nrf2 activation and epigenetic regulation

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