Schisandra Chinensis-dependent Myocardial Protective Action of Sheng-Mai-San in Rats

Abstract

Sheng-Mai-San (SMS), a traditional Chinese formulation used for the treatment of coronary heart disease, is comprised of Radix Ginseng, Fructus Schisandrae and Radix Ophiopogonis. Pretreatment with a lignan-enriched SMS (17 g/kg/day x 3, p.o.) was found effective in protection against isoproterenol-induced myocardial injury in rats, and in ischemia-reperfusion injury in isolated perfused hearts prepared from pretreated animals. Results obtained from pretreatment studies using extracts prepared by mixing various combinations of the three component herbs indicate that the major myocardial protective component in SMS is the lignan-enriched extract of Fructus Schisandrae.

The mechanism of vasorelaxation induced by Schisandra chinensis extract in rat thoracic aorta

“…This finding is consistent with results obtained from Rhyu et al that aqueous extract of Schisandra chinensis caused both endothelium-dependent and independent vasorelaxation (Rhyu et al, 2006). In addition, a lignan-enriched extract of Schizandra had myocardial protective effect in vivo and ex vivo models in rats (Li et al, 1996). Further work is necessary to isolate, identify and characterize the active components of Schisandra chinensis and those acting on endothelial and smooth muscle cells.…”

Immunomodulatory and antioxidants properties of fixed combination of fish oil with plant extracts

“…Schisandrin B pretreatment (0.3 mmol/3.0 mmol/kg/day x 3) produced a dose-dependent protective effect on the CCl 4 -induced hepatotoxicity in mice [41]. The antioxidant activity of Schizandra lignans play a leading role in the hepatoprotective [9,42,43], myocardial protective [44,45] and anti-inflammatory [46] actions of Schizandra preparations.…”

Pharmacology of Schisandra chinensis Bail.: An overview of Russian research and uses in medicine

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“…Similar antioxidative effects were also observed in intact rats. It should be stressed that the antioxidant activity of Schizandra lignans play a leading role in the hepatoprotective (Liu and Lesca, 1982a,b;Liu, 1991, 1992;Liu et al, 1992;Ip et al, 1995Ip et al, , 1996, myocardial protective (McCord, 1988;Li et al, 1996Li et al, , 1997 anti-tumour (Yasukawa et al, 1992) and anti-inflammatory (Wang et al, 1994) actions of Schizandra preparations. These lignans also exhibit a protective action in oxidative stress-associated disorders such as ageing-related brain ischemia (Xue et al, 1992).…”