<i>Scedosporium apiospermum</i>: a rare cause of malignant otitis externa

McLaren, Oliver; Potter, Christian

doi:10.1136/bcr-2016-217015

Cited by 13 publications

(11 citation statements)

References 6 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies on MOE have reported increased causative pathogen diversity: Klebsiella species (1), Aspergillus avus (3), and Actinomyces (6). Furthermore, Mc Laren et al described MOE with a rare fungal etiologic pathogen -Scedosporium apiospermum (7). In all cases, including ours, DM was associated co-morbidity.…”

Section: Discussionmentioning

confidence: 53%

Malignant Otitis Externa in an Adult Diabetic Patient Caused by Escherichia coli: a Case Report

Batinović

Kujundžić

Golec

et al. 2023

SN Compr. Clin. Med.

View full text Add to dashboard Cite

Introduction: Malignant otitis externa (MOE) is commonly presented as invasive external otitis resistant to local treatment that classically affects elderly diabetic patients.Case presentation: We presented a 55-year-old man with a history of diabetes mellitus (DM) and ear scratching, initially manifesting with left-sided nocturnal otalgia, purulent otorrhea, and external auditory canal (EAC) edema. A diagnosis of MOE was made based on Levenson's criteria and radiological ndings. Antibiotics were given intravenously based on bacterial cultures from ear swabs, with repeated cultures growing Escherichia coli (E. coli). The patient's MOE caused by E. coli improved after two months of ear toilets, DM management, parenteral and local antibiotics, and hyperbaric oxygen therapy (HBOT).We detected that the MOE was caused by self-in icted local trauma to the EAC on the same side as the dominant hand. Conclusion:The isolation of E. coli from the EAC as the causative organism of MOE with a favorable response to HBOT as an adjunction to antibiotic therapy was previously unreported and could present a novel treatment strategy.

show abstract

Section: Discussionmentioning

confidence: 53%

Malignant Otitis Externa in an Adult Diabetic Patient Caused by Escherichia coli: a Case Report

Batinović

Kujundžić

Golec

et al. 2023

SN Compr. Clin. Med.

View full text Add to dashboard Cite

show abstract

“…The 68 studies included a total of 74 individual cases of fungal TBO (Tables 3 and 4) (8,12,24–89). The mean age (SD) was 55.5 (23.3) years, and 74.3% (55/74) were male.…”

Section: Resultsmentioning

confidence: 99%

Trends and Outcomes of Fungal Temporal Bone Osteomyelitis: A Scoping Review

et al. 2022

View full text Add to dashboard Cite

IntroductionTemporal bone osteomyelitis is an invasive infection most often caused by bacteria and associated with high mortality. Fungal etiologies are rare and little is known of the predictors of disease severity and outcomes in fungal temporal bone osteomyelitis.Materials and MethodsA scoping review was performed to determine what is known from the literature on how clinical, diagnostic, and treatment characteristics relate to patient outcomes in fungal temporal bone osteomyelitis. Using PRISMA guidelines, three databases were searched to identify all published cases of fungal temporal bone osteomyelitis. Data were extracted from each study, including clinical, diagnostic, and treatment characteristics, and outcomes.ResultsSixty-eight studies comprising 74 individual cases of fungal temporal bone osteomyelitis were included. All studies were case reports. There were high rates of diabetes, facial nerve palsy, infectious complications, and need for surgical intervention, as well as a significant delay in the evaluation and diagnosis of fungal temporal bone osteomyelitis. Disease recovery was greater in patients presenting with otorrhea, comorbid diabetes, and in those without facial nerve palsy.DiscussionMany of the defining characteristics of fungal temporal bone osteomyelitis remain unknown, and future reports should focus on determining factors that improve timely diagnosis and treatment of fungal TBO in addition to identifying prognostic indicators for outcomes and survival.

show abstract

“…SBO secondary to fungal species, particularly with S. apiospermum, can lead to fatal complications such as mycotic aneurysms and cerebral infractions [ 3 , 5 ]. In addition, delay in early recognition and treatment can also lead to cranial nerve palsies, intracranial abscesses, and sinus thrombosis [ 6 ]. Johnson et al reported that mortality in SBO is high and can reach up to 10 to 20% [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Rare Cause of Skull Base Osteomyelitis: A Challenging Diagnosis and Management With a Literature Review

Hussain,

Haq,

Arshad

et al. 2023

Cureus

View full text Add to dashboard Cite

This is a case of skull base osteomyelitis (SBO) caused by a rare fungal species, Scedosporium apiospermum. This is a clinical case report with a review of the literature. SBO is a potentially life-threatening infection of the temporal bone. The patient presented to our hospital with a two-month history of left otalgia, otorrhea and reduced hearing, after failed initial intravenous antibiotic therapy. Thorough examination and further investigation confirmed the diagnosis of SBO caused by a rare fungal species, S. apiospermum. The patient was subsequently started on a long-term course of antifungals which led to an improvement of symptoms. This case highlights the importance of early recognition and considering early antifungal treatment in patients with persistent otalgia and otorrhea, particularly in those who have failed to respond to intravenous antibiotics. Further research is needed to better understand the optimal timing and duration of antifungal therapy in these patients.

show abstract

Scedosporium apiospermum: a rare cause of malignant otitis externa

Cited by 13 publications

References 6 publications

Malignant Otitis Externa in an Adult Diabetic Patient Caused by Escherichia coli: a Case Report

Malignant Otitis Externa in an Adult Diabetic Patient Caused by Escherichia coli: a Case Report

Trends and Outcomes of Fungal Temporal Bone Osteomyelitis: A Scoping Review

Rare Cause of Skull Base Osteomyelitis: A Challenging Diagnosis and Management With a Literature Review

Contact Info

Product

Resources

About