<i>Sasa quelpaertensis</i>and<i>p</i>-Coumaric Acid Attenuate Oleic Acid-Induced Lipid Accumulation in HepG2 Cells

Kim, Jeong‐Hwan; Kang, Seong-Il; Shin, Hye-Sun; Yoon, Seon-A; Kang, Seung-Woo; Ko, Hee-Chul; Kim, Se-Jae

doi:10.1271/bbb.130167

Cited by 34 publications

(17 citation statements)

References 15 publications

(15 reference statements)

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“…SQE has shown beneficial effects on colitis in previous studies. Moreover, the bioactive component of SQE, tricin and p -coumaric acid, have exhibited antioxidant, anti-inflammatory, and anticancer effects which remain to be investigated in relation to gut microbiota [17, 18, 20, 34]. …”

Section: Discussionmentioning

confidence: 99%

“…Its leaf extract has been reported to mediate various health promoting properties, including anti-inflammation, anti-cancer effects, and anti-obesity effect [16–18]. Sasa quelpaertensis leaves extract (SQE) is a mixture of polysaccharides, amino acids, and polyphenols, including p -coumaric acid and tricin, and has exhibited anti-inflammatory and anti-obesity effects [19, 20]. In particular, SQE has been found to mediate anti-inflammatory effects by regulating inflammatory mediators such as nitric oxide, tumor necrosis factor α, and COX-2 both in vivo and in vitro [17].…”

Section: Introductionmentioning

confidence: 99%

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Sasa quelpaertensis leaf extract regulates microbial dysbiosis by modulating the composition and diversity of the microbiota in dextran sulfate sodium-induced colitis mice

Yeom

Kim

et al. 2016

BMC Complement Altern Med

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BackgroundInflammatory bowel diseases (IBD) are related to a dysfunction of the mucosal immune system and they result from complex interactions between genetics and environmental factors, including lifestyle, diet, and the gut microbiome. Therefore, the effect of Sasa quelpaertensis leaf extract (SQE) on gut microbiota in a dextran sulfate sodium (DSS)-induced colitis mouse model was investigated with pyrosequencing of fecal samples.MethodsThree groups of animals were examined: i) a control group, ii) a group that was received 2.5% DSS in their drinking water for 7 days, followed by 7 days of untreated water, and then another 7 days of 2.5% DSS in their drinking water, and iii) a group that was presupplemented with SQE (300 mg/kg body weight) by gavage for two weeks prior to the same DSS treatment schedule described in ii.ResultsSQE supplementation alleviated disease activity scores and shortened colon length compared to the other two groups. In the DSS group, the proportion of Bacteroidetes increased, whereas that the proportion of Firmicutes was decreased compared to the control group. SQE supplementation recovered the proportions of Firmicutes and Bacteroidetes back to control levels. Moreover, the diversity of microbiota in the SQE supplementation group higher than that of the DSS group.ConclusionSQE was found to protect mice from microbial dysbiosis associated with colitis by modulating the microbial composition and diversity of the microbiota present. These results provide valuable insight into microbiota-food component interactions in IBD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sasa quelpaertensis leaf extract regulates microbial dysbiosis by modulating the composition and diversity of the microbiota in dextran sulfate sodium-induced colitis mice

Yeom

Kim

et al. 2016

BMC Complement Altern Med

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“…This result is consistent with their numerically lower liver weight (Table ), less dyed‐in‐red hepatic lipid droplets (Figure ), and normalized hepatic structure (Figure ). Decrease of HMG‐CoA reductase activity, elevation of AMPK phosphorylation, and inhibition of fatty acids synthase expression might be the possible mechanisms for gallic acid and ρ‐coumaric acid to exhibit preventive effects on hepatic lipid accumulation (Kim et al, ; Punithavathi, Stanely Mainzen Prince, Kumar, & Selvakumari, ). In NAFLD patients, fat accumulation in liver usually accompanied with hepatic enzymes released into serum (Ekstedt et al, ).…”

Section: Resultsmentioning

confidence: 99%

Phenolic acids alleviate high-fat and high-fructose diet-induced metabolic disorders in rats

Guo

Wang

et al. 2017

J Food Biochem

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Phenolic acids are naturally occurring compounds with meritorious physiological activities. The purpose of this study was to compare the ameliorative effects of six common phenolic acids on diet‐induced metabolic syndrome (MS) in rats. SD rats were fed with high‐fat and high‐fructose diet supplemented with equimolar concentration of individual phenolic acids for 13 weeks. Results showed that different phenolic acids ameliorated MS through different ways. Compared with other phenolic acids, caffeic acid exerted more comprehensive effect in alleviating MS, with significant effects in attenuating hyperlipidemia, elevating glucose tolerance, improving antioxidant status, and normalizing hepatic functions. Ellagic acid exhibited good performance in hypolipidemia, anti‐inflammation, and reducing visceral fat. Gallic acid and ρ‐coumaric acid showed marked effects in regulating liver steatosis, while chlorogenic acid exhibited potential hepatic protective and anti‐inflammatory abilities. These results will benefit the application of these phenolic acids in the development of functional food for MS population. Practical applications The high morbidity of metabolic syndrome (MS) has driven people to seek for natural and safe compounds to maintain optimal health. Different phenolic acids were shown to ameliorate MS through different ways, which provides experimental basis for developing combinations or formulas of phenolic acids with more comprehensive effects. Conversely, caffeic acid showed relatively better effects in attenuating features of metabolic disorders, and was suggested for the future development of functional foods for the population with MS.

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“…AMPK is an evolutionarily conserved metabolic stress-sensing kinase that regulates cellular energy status through phosphorylation of key substrates (23). An in vitro study identified that activation of AMPK increases the expression of CPT1a (24). Dahlhoff et al (25) demonstrated that methyl-donor supplementation (MDS) in obese mice prevented the progression of NAFLD, and suggested that MDS activates AMPK and increases CPT1a expression in the liver, resulting in the promotion of fatty acid oxidation.…”

Section: Discussionmentioning

confidence: 99%

Alogliptin alleviates hepatic steatosis in a mouse model of nonalcoholic fatty liver disease by promoting CPT1a expression via Thr172 phosphorylation of AMPKα in the liver

et al. 2018

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Pioglitazone (PIO) has been reported to be effective for nonalcoholic fatty liver disease (NAFLD) and alogliptin (ALO) may have efficacy against NAFLD progression in patients with type 2 diabetes mellitus (T2DM). The present study examined the effectiveness of ALO in a rodent model of NAFLD and diabetes mellitus. KK‑Ay mice were used to produce an NAFLD model via administration of a choline‑deficient (CD) diet. To examine the effects of alogliptin, KK‑Ay mice were provided with a CD diet with 0.03% ALO and/or 0.02% PIO orally for 8 weeks. Biochemical parameters, pathological alterations and hepatic mRNA levels associated with fatty acid metabolism were assessed. Severe hepatic steatosis was observed in KK‑Ay mice fed with a CD diet, which was alleviated by the administration of ALO and/or PIO. ALO administration increased the hepatic carnitine palmitoyltransferase 1a (CPT1a) mRNA expression level and enhanced the Thr172 phosphorylation of AMP‑activated protein kinase α (AMPKα) in the liver. PIO administration tended to decrease the hepatic fatty acid synthase mRNA expression level and increase the serum adiponectin level. Homeostasis model of assessment‑insulin resistance values tended to improve with ALO and PIO administration. ALO and PIO alleviated hepatic steatosis in KK‑Ay mice fed with a CD diet. ALO increased hepatic mRNA expression levels associated with fatty acid oxidation. In addition, the results of the present study suggested that ALO promotes CPT1a expression via Thr172 phosphorylation of AMPKα.

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Sasa quelpaertensisandp-Coumaric Acid Attenuate Oleic Acid-Induced Lipid Accumulation in HepG2 Cells

Cited by 34 publications

References 15 publications

Sasa quelpaertensis leaf extract regulates microbial dysbiosis by modulating the composition and diversity of the microbiota in dextran sulfate sodium-induced colitis mice

Sasa quelpaertensis leaf extract regulates microbial dysbiosis by modulating the composition and diversity of the microbiota in dextran sulfate sodium-induced colitis mice

Phenolic acids alleviate high-fat and high-fructose diet-induced metabolic disorders in rats

Alogliptin alleviates hepatic steatosis in a mouse model of nonalcoholic fatty liver disease by promoting CPT1a expression via Thr172 phosphorylation of AMPKα in the liver

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