<i>Sargassum polycystum</i> reduces hyperglycaemia, dyslipidaemia and oxidative stress via increasing insulin sensitivity in a rat model of type 2 diabetes

Motshakeri, Mahsa; Ebrahimi, Mahdi; Goh, Yong Meng; Matanjun, Patricia; Mohamed, Suhaila

doi:10.1002/jsfa.5971

Cited by 51 publications

(44 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, S. polycystum, a brown edible seaweed, exhibited moderate α-amylase inhibitory activity (46 %) which was in agreement with previous reports suggesting the anti-diabetic potential of this seaweed (Motshakeri et al 2013). Brown seaweeds are the most extensively studied marine algae for antidiabetic benefits.…”

Section: Discussionsupporting

confidence: 91%

Alpha-amylase, antioxidant, and anti-inflammatory activities of Eucheuma denticulatum (N.L. Burman) F.S. Collins and Hervey

et al. 2015

View full text Add to dashboard Cite

Eucheuma denticulatum is a red edible seaweed that grows in the East Malaysia coastal region. The objective of this study was to investigate the α-amylase, antioxidant and anti-inflammatory activities of E. denticulatum ethanol extract and its three fractions (n-hexane, ethyl acetate and acetone). α-Amylase activity was assessed by dinitrosalicylic acid (DNS) assay, while the antioxidant property was determined by oxygen radical absorbance capacity (ORAC) analysis. The anti-inflammatory effects of the seaweed samples were evaluated by nitric oxide (NO), interleukin-6 (IL-6), interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) activities on the interferon-gamma/lipopolysaccharide (IFN-γ/LPS)-stimulated murine macrophage cell line (RAW 264.7) using Griess reaction and immunoassays, respectively. At 10 mg mL −1 , E. denticulatum ethanol extract and three fractions inhibited α-amylase activities at variable levels. The highest (67 %) inhibition of α-amylase enzyme was by the ethanol crude extract. The three fractions showed inhibition with a mean of 42 %. Crude ethanol extracts also exhibited higher antioxidant capacity (36,400 ±23.5 mol Trolox equivalent (TE) (100 g) −1 ) when compared to the fractions. Crude extract and fractions (1-100 μg mL −1 ), also exhibited anti-inflammatory activity without showing any cytotoxic effect to RAW 264.7 cells. The present study suggests that E. denticulatum has the potential to be a promising source of effective functional metabolite. An extensive research on the edible varieties would contribute to a better understanding of their importance as functional food.

show abstract

Section: Discussionsupporting

confidence: 91%

Alpha-amylase, antioxidant, and anti-inflammatory activities of Eucheuma denticulatum (N.L. Burman) F.S. Collins and Hervey

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The phytochemicals and soluble fibres present in the extracts of S. polycystum have cholesterol-lowering effects and affect intestinal glucose absorption (Taskinen 2002;Vaugelade et al 2000). The aqueous extract of S. polycystum contains mostly sulphated polysaccharides, which can reduce hyperglycaemia, dyslipidaemia and oxidative stress by increasing insulin sensitivity in rat models of type 2 diabetes (Motshakeri et al 2013). Along with these reported studies, the present investigation adds strong supporting evidence that members of the species Sargassum (S. polycystum and S. wightii) are an excellent source of α-amylase, α-glucosidase and DPP-IV inhibitors.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic potential of marine algae by inhibiting key metabolic enzymes

Unnikrishnan

Suthindhiran

Jayasri

2015

Frontiers in Life Science

View full text Add to dashboard Cite

Two edible seaweeds, Sargassum polycystum and Sargassum wightii, were investigated for their antidiabetic potential using in vitro enzyme inhibitory assays. Among the various extracts, petroleum ether and ethyl acetate extracts of S. wightii showed significant inhibitory effects against α-amylase (IC 50 378.3 μg/ml) and α-glucosidase (IC 50 314.8 μg/ml). Methanol extract of S. wightii showed the highest inhibition against dipeptidyl peptidase-IV (DPP-IV) (IC 50 38.27 μg/ml) and moderate antioxidant activity was observed in acetone extract of S. wightii (44%). Similarly, ethyl acetate extract of S. polycystum showed the highest inhibition against α-amylase (IC 50 438.5 μg/ml) and methanol extract of S. polycystum showed maximum inhibition against α-glucosidase (IC 50 289.7 μg/ml) and DPP-IV (36.94 μg/ml). The antioxidant activity was poor (22%). The extracts were investigated for in vitro cytotoxicity, DNA fragmentation in macrophages and haemolytic activity against erythrocytes, but no notable toxicity was observed with any of the tested extracts. Gas chromatography-mass spectrometry revealed the presence of the antidiabetic compound fucosterol and other major bioactive compounds, giving an insight into the antidiabetic and antioxidant properties of these algae. This study reveals the possible mechanisms of antidiabetic action in vitro, and these two seaweeds may also have an antidiabetic action in vivo.

show abstract

“…In vivo studies and histopathological examinations are necessary to prove their efficacy and safety on the liver, kidney, pancreas, and the other important organs, since biochemical measurements alone are not conclusive. The common edible brown seaweed Sargassum polycystum ( C. Agardh ) (SP) reportedly alleviated hyperglycaemia and dislipidemia in diabetic rats [13], possibly due to its good antioxidant and free radical scavenging properties [14]. SP is reportedly used for eczema, scabies, and psoriasis, ulcer and lung diseases, renal dysfunction, viral hepatitis and heart ailments and to promote bile secretion [7], besides having antilipidemic, antioxidant and membrane stabilizing properties [8, 15].…”

Section: Introductionmentioning

confidence: 99%

“…It was reported to be hepatoprotective under high-fat/high-cholesterol diet [16]. The administration of SP ethanolic or water extracts dose dependently reduced blood glucose, glycosylated hemoglobin (HbA1C) levels, and dyslipidemia in type 2 diabetic animals [13]. SP appeared to be an insulin sensitizer, beneficial in the management of T2DM that can also help reduce atherogenic risk [13].…”

Section: Introductionmentioning

confidence: 99%

Effects of Brown Seaweed (Sargassum polycystum) Extracts on Kidney, Liver, and Pancreas of Type 2 Diabetic Rat Model

Motshakeri

Ebrahimi

Goh

et al. 2014

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

The edible seaweed Sargassum polycystum (SP) is traditionally used against several human diseases. This investigation evaluated the effects of two dietary doses of SP ethanolic and aqueous extracts on the pancreatic, hepatic, and renal morphology of type 2 diabetic rats (T2DM). T2DM was induced by feeding rats on high calorie diet followed by a low dose streptozotocin. Changes in the diabetic rat organs in SP treated groups with different doses of extracts were compared with normal rats, diabetic control rats, and metformin treated rats. After 22 days of treatment, the pathological lesions of the livers and kidneys in the diabetic rats were quantitatively and qualitatively alleviated (P < 0.05) by both the SP extracts at 150 mg/kg body weight and by metformin. All the treated diabetic groups revealed marked improvement in the histopathology of the pancreas compared with the control diabetic group. Oral administration of 300 mg/kg body weight of aqueous and ethanolic extracts of SP and metformin revealed pancreas protective or restorative effects. The seaweed extracts at 150 mg/kg body weight reduced the liver and kidney damages in the diabetic rats and may exert tissue repair or restoration of the pancreatic islets in experimentally induced diabetes to produce the beneficial homeostatic effects.

show abstract

Sargassum polycystum reduces hyperglycaemia, dyslipidaemia and oxidative stress via increasing insulin sensitivity in a rat model of type 2 diabetes

Cited by 51 publications

References 33 publications

Alpha-amylase, antioxidant, and anti-inflammatory activities of Eucheuma denticulatum (N.L. Burman) F.S. Collins and Hervey

Alpha-amylase, antioxidant, and anti-inflammatory activities of Eucheuma denticulatum (N.L. Burman) F.S. Collins and Hervey

Antidiabetic potential of marine algae by inhibiting key metabolic enzymes

Effects of Brown Seaweed (Sargassum polycystum) Extracts on Kidney, Liver, and Pancreas of Type 2 Diabetic Rat Model

Contact Info

Product

Resources

About