<i>Sargassum fusiforme</i> Fucoidan Alleviates High-Fat Diet-Induced Obesity and Insulin Resistance Associated with the Improvement of Hepatic Oxidative Stress and Gut Microbiota Profile

Zhang, Ya; Zuo, Jihui; Yan, Liping; Yang, Cheng; Li, Qiaojuan; Wu, Siya; Chen, Ling; Thring, Ronald W.; Yang, Yue; Gao, Yitian; Wu, Mingjiang; Tong, Haibin

doi:10.1021/acs.jafc.0c02555

Cited by 73 publications

(63 citation statements)

References 65 publications

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“…Fucoidan from S. fusiforme changed the gut microbiota, particularly by increasing the Bacteroidetes to Firmicutes ratio, to decrease streptozotocin-induced hyperglycaemia in mice [ 48 ]. Further, fucoidan from S. fusiforme decreased high-fat-diet-induced insulin resistance in mice by activating the Nrf2 pathway, changing the gut microbiota and reducing intestinal inflammation [ 49 ]. Fucoidan supplementation of 100 mg/kg/day in high-fat-diet-fed rats improved blood lipid concentrations, decreased fat deposition in the liver and changed the gut microbiota [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Brown Seaweed Sargassum siliquosum as an Intervention for Diet-Induced Obesity in Male Wistar Rats

et al. 2021

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The therapeutic potential of Sargassum siliquosum grown in Australian tropical waters was tested in a rat model of metabolic syndrome. Forty-eight male Wistar rats were divided into four groups of 12 rats and each group was fed a different diet for 16 weeks: corn starch diet (C); high-carbohydrate, high-fat diet (H) containing fructose, sucrose, saturated and trans fats; and C or H diets with 5% S. siliquosum mixed into the food from weeks 9 to 16 (CS and HS). Obesity, hypertension, dyslipidaemia, impaired glucose tolerance, fatty liver and left ventricular fibrosis developed in H rats. In HS rats, S. siliquosum decreased body weight (H, 547 ± 14; HS, 490 ± 16 g), fat mass (H, 248 ± 27; HS, 193 ± 19 g), abdominal fat deposition and liver fat vacuole size but did not reverse cardiovascular and liver effects. H rats showed marked changes in gut microbiota compared to C rats, while S. siliquosum supplementation increased gut microbiota belonging to the family Muribaculaceae. This selective increase in gut microbiota likely complements the prebiotic actions of the alginates. Thus, S. siliquosum may be a useful dietary additive to decrease abdominal and liver fat deposition.

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Section: Discussionmentioning

confidence: 99%

Brown Seaweed Sargassum siliquosum as an Intervention for Diet-Induced Obesity in Male Wistar Rats

et al. 2021

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“…It has been shown that the ethanoic extracts of Garcinia brasiliensis can effectively reduce the growth of Firmicutes and Proteobacteria together with the expressions of an oxidative stress marker malondialdehyde (Ara ujo et al 2019). Another study suggests that the Sargassum fusiforme fucoidan can improve antioxidant status by lowering malondialdehyde levels, increasing GSH/GSSG ratio and activating Nrf2 signalling pathway in a mechanism involving the promotion of Bacteroides, Alistipes, Lactobacillus and reduction of Helicobacter in HFD-fed mice (Zhang et al 2020). Collectively, the evidence above suggests that GM is involved in the regulation of oxidative stress and its alteration can reverse obese features.…”

Section: Gm and Oxidative Stressmentioning

confidence: 99%

Impact of the factors shaping gut microbiota on obesity

et al. 2021

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Obesity is considered as a risk factor for chronic health diseases such as heart diseases, cancer and diabetes 2. Reduced physical activities, lifestyle, poor nutritional diet and genetics are among the risk factors associated with the development of obesity. In recent years, several studies have explored the link between the gut microbiome and the progression of diseases including obesity, with the shift in microbiome abundance and composition being the main focus. The alteration of gut microbiome composition affects both nutrients metabolism and specific gene expressions, thereby disturbing body physiology. Specifically, the abundance of fibre-metabolizing microbes is associated with weight loss and that of protein and fat-metabolizing bacteria with weight gain. Various internal and external factors such as genetics, maternal obesity, mode of delivery, breastfeeding, nutrition, antibiotic use and the chemical compounds present in the environment are known to interfere with the richness of the gut microbiota (GM), thus influencing weight gain/loss and ultimately the development of obesity. However, the effectiveness of each factor in potentiating the shift in microbes' abundance to result in significant changes that can lead to obesity is not yet clear. In this review, we will highlight the factors involved in shaping GM, their influence on obesity and possible interventions. Understanding the influence of these factors on the diversity of the GM and how to improve their effectiveness on disease conditions could be keys in the treatment of metabolic diseases.

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“…Of these, fucoidan and carrageenan are beneficial sulphated polysaccharides, which exhibit anti-obesity properties through altering the composition of gut microbiota 2 . These polysaccharides were extensively studied using high fat diet-induced obese mice and clinical trials with obese population, and these studies proved that their anti-obesity properties were involved in the reduction of Bacteroidetes / Firmicutes ratio 3 , which is a relevant marker of gut dysbiosis in obese population, increased diversity of microbiota 4 , 5 , and increase in specific gut bacteria 5 , 6 .…”

Section: Introductionmentioning

confidence: 99%

Rhamnan sulphate from green algae Monostroma nitidum improves constipation with gut microbiome alteration in double-blind placebo-controlled trial

Terasawa

Okazaki

Nakayama

et al. 2021

Sci Rep

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Rhamnan sulphate (RS), a sulphated polysaccharide from Monostroma nitidum, possesses several biological properties that help in treating diseases such as viral infection, thrombosis, and obesity. In the present study, we first administered RS (0.25 mg/g food volume) orally to high-fat diet-treated mice for 4 weeks. RS increased the faecal volume and calorie excretion with decreased plasma lipids, which was in accordance with the results of our previous zebrafish study. Notably, as the excretion amount by RS increased in the mice, we hypothesised that RS could decrease the chance of constipation in mice and also in human subjects because RS is considered as a dietary fibre. We administrated RS (100 mg/day) to subjects with low defaecation frequencies (3–5 times/week) for 2 weeks in double-blind placebo-controlled manner. As a result, RS administration significantly increased the frequency of dejection without any side effects, although no effect was observed on the body weight and blood lipids. Moreover, we performed 16s rRNA-seq analysis of the gut microbiota in these subjects. Metagenomics profiling using PICRUSt revealed functional alternation of the KEGG pathways, which could be involved in the therapeutic effect of RS for constipation.

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Sargassum fusiforme Fucoidan Alleviates High-Fat Diet-Induced Obesity and Insulin Resistance Associated with the Improvement of Hepatic Oxidative Stress and Gut Microbiota Profile

Cited by 73 publications

References 65 publications

Brown Seaweed Sargassum siliquosum as an Intervention for Diet-Induced Obesity in Male Wistar Rats

Brown Seaweed Sargassum siliquosum as an Intervention for Diet-Induced Obesity in Male Wistar Rats

Impact of the factors shaping gut microbiota on obesity

Rhamnan sulphate from green algae Monostroma nitidum improves constipation with gut microbiome alteration in double-blind placebo-controlled trial

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