<i>Salvia hispanica</i> L. (chia) seed improves liver inflammation and endothelial dysfunction in an experimental model of metabolic syndrome

Joubert, Michelle; Degrave, Valentina; Ingaramo, Paola I.; Oliva, María Eugenia; D'Alessandro, María Eugenia

doi:10.1039/d2fo02216h

Cited by 6 publications

(3 citation statements)

References 60 publications

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“…Chia (Salvia hispanica L.) is considered a potentially bioactive food source since it has demonstrated multiple health benefits, such as a decrease in adiposity, modulation of the glucose metabolism [1], a hypoglycemic effect, a reduction in hepatic fat deposition [2], an improved lipid profile [2][3][4][5], reductions in inflammatory processes [4][5][6], antioxidant protection [4,7] and reduced fat content of the heart [7]. Regarding intestinal health, chia seeds have been shown to improve the intestinal brush border membrane and favored its functionality [2,[8][9][10], increasing the production of short-chain fatty acids and increasing the richness of the microbiota [9,10].…”

Section: Introductionmentioning

confidence: 99%

Effects of Intra-Amniotic Administration of the Hydrolyzed Protein of Chia (Salvia hispanica L.) and Lacticaseibacillus paracasei on Intestinal Functionality, Morphology, and Bacterial Populations, In Vivo (Gallus gallus)

et al. 2023

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As a protein source, chia contains high concentrations of bioactive peptides. Probiotics support a healthy digestive tract and immune system. Our study evaluated the effects of the intra-amniotic administration of the hydrolyzed chia protein and the probiotic Lacticaseibacillus paracasei on intestinal bacterial populations, the intestinal barrier, the inflammatory response, and brush border membrane functionality in ovo (Gallus gallus). Fertile broiler (Gallus gallus) eggs (n = 9/group) were divided into 5 groups: (NI) non-injected; (H2O) 18 MΩ H2O; (CP) 10 mg/mL hydrolyzed chia protein; (CPP) 10 mg/mL hydrolyzed chia protein + 106 colony-forming unit (CFU) L. paracasei; (P) 106 CFU L. paracasei. The intra-amniotic administration was performed on day 17 of incubation. At hatching (day 21), the animals were euthanized, and the duodenum and cecum content were collected. The probiotic downregulated the gene expression of NF-κβ, increased Lactobacillus and E. coli, and reduced Clostridium populations. The hydrolyzed chia protein downregulated the gene expression of TNF-α, increased OCLN, MUC2, and aminopeptidase, reduced Bifidobacterium, and increased Lactobacillus. The three experimental groups improved in terms of intestinal morphology. The current results suggest that the intra-amniotic administration of the hydrolyzed chia protein or a probiotic promoted positive changes in terms of the intestinal inflammation, barrier, and morphology, improving intestinal health.

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Section: Introductionmentioning

confidence: 99%

Effects of Intra-Amniotic Administration of the Hydrolyzed Protein of Chia (Salvia hispanica L.) and Lacticaseibacillus paracasei on Intestinal Functionality, Morphology, and Bacterial Populations, In Vivo (Gallus gallus)

et al. 2023

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“…The supplementation of chia oil improves oxidative stress of the liver via transcription factors PPAR-γ and Nrf2 upregulation involving antioxidant responses [137]. In addition, chia seeds ameliorate endothelial dysfunction in metabolic syndrome, liver inflammation or injury, and oxidative stress [138,139]. Extracted mucilage from chia seed showed a prominence of novel biological activities, such as mucoadhesive properties that can be potentially applied for developing various pharmaceutical and cosmetic products [140].…”

Section: Value-added Food Products and Other Potential Applicationsmentioning

confidence: 99%

Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds

Agarwal¹,

Rizwana²,

Tripathi

et al. 2023

Antioxidants

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Quinoa (Chenopodium quinoa Willd) and chia (Salvia hispanica) are essential traditional crops with excellent nutritional properties. Quinoa is known for its high and good quality protein content and nine essential amino acids vital for an individual’s development and growth, whereas chia seeds contain high dietary fiber content, calories, lipids, minerals (calcium, magnesium, iron, phosphorus, and zinc), and vitamins (A and B complex). Chia seeds are also known for their presence of a high amount of omega-3 fatty acids. Both quinoa and chia seeds are gluten-free and provide medicinal properties due to bioactive compounds, which help combat various chronic diseases such as diabetes, obesity, cardiovascular diseases, and metabolic diseases such as cancer. Quinoa seeds possess phenolic compounds, particularly kaempferol, which can help prevent cancer. Many food products can be developed by fortifying quinoa and chia seeds in different concentrations to enhance their nutritional profile, such as extruded snacks, meat products, etc. Furthermore, it highlights the value-added products that can be developed by including quinoa and chia seeds, alone and in combination. This review focused on the recent development in quinoa and chia seeds nutritional, bioactive properties, and processing for potential human health and therapeutic applications.

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“…9 These benefits are due to its nutritional composition as a source of dietary fiber and bioactive compounds. [10][11][12] About gut health, chia may be a viable dietary ingredient that may improve gut health and contribute to intestinal mineral absorption. The intra-amniotic (in ovo) administration of chia seed soluble extracts improved the intestinal morphology, up-regulated Zn-related and iron-related protein gene expression, and increased the relative abundance of Bifidobacterium and Lactobacillus.…”

Section: Introductionmentioning

confidence: 99%

Chia flour combined with a high fat diet increases propionic acid production and improves the microbial richness and diversity in female Wistar rats

Mishima,

da Silva,

Gomes

et al. 2023

Food Funct.

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Salvia hispanica L. (chia) seed improves liver inflammation and endothelial dysfunction in an experimental model of metabolic syndrome

Abstract: The purposes of the present study were to analyze liver inflammation and endothelial dysfunction in an experimental model of Metabolic Syndrome (MS) induced by chronic administration of a sucrose-rich diet...

Cited by 6 publications

References 60 publications

Effects of Intra-Amniotic Administration of the Hydrolyzed Protein of Chia (Salvia hispanica L.) and Lacticaseibacillus paracasei on Intestinal Functionality, Morphology, and Bacterial Populations, In Vivo (Gallus gallus)

Effects of Intra-Amniotic Administration of the Hydrolyzed Protein of Chia (Salvia hispanica L.) and Lacticaseibacillus paracasei on Intestinal Functionality, Morphology, and Bacterial Populations, In Vivo (Gallus gallus)

Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds

Chia flour combined with a high fat diet increases propionic acid production and improves the microbial richness and diversity in female Wistar rats

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