Salmonella newportcausing osteomyelitis in a patient with diabetes

Abstract

Salmonella is a foodborne pathogen that commonly causes intestinal symptoms. Bacteraemia and extraintestinal infections have been documented within the literature, and are more frequently associated with immunodeficiency and general debilitation. We discuss the case of a previously well 36-year-old man who presented with a septic knee and new-onset diabetes. Imaging confirmed osteomyelitis and a Brodie's abscess, with blood and tissue cultures revealing the isolate Salmonella enterica newport. He denied any previous gastrointestinal symptoms, recent travel, change in usual dietary habit or symptoms of diabetes. So far there have only been three reported cases of S. newport causing osteomyelitis. We discuss the incidence of Salmonella infections, including extraintestinal symptoms, its relation to immunodeficiency and the disease burden of S. newport.

Non-HIV Male with Urinary Tract Infection by Salmonella Enteritidis

“…It would be interesting to clarify whether diabetes mellitus could be related to an increased susceptibility of infection by Salmonella. Other authors relate the presence of diabetes mellitus to a higher risk of neck abscesses [9] and osteomyelitis [10]. It is thus not improbable that diabetes mellitus could also be a risk factor for UTI produced by Salmonella.…”

Genomic Identification of Multidrug-Resistant Salmonella Virchow Monophasic Variant Causing Human Septic Arthritis

“…S . Newport was also reported to cause left knee pain in a 36-year-old man with a fever of 38 °C and new-onset diabetes, whereas the bacteria were isolated from his blood, pus, knee aspirate, and tibia tissue [ 7 ]. S. Montevideo was another rare Salmonella serovar, identified to induce septic arthritis of the knee in a 59-year-old woman who presented with a painful and swollen right knee associated with a fever of 38.8 °C [ 8 ].…”

“…S. Montevideo was another rare Salmonella serovar, identified to induce septic arthritis of the knee in a 59-year-old woman who presented with a painful and swollen right knee associated with a fever of 38.8 °C [ 8 ]. S. Virchow has also been connected with meningitis and knee septic arthritis [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ].…”

“…Meningitis is diagnosed in less than 1% of clinical salmonellosis; Salmonella infections account for 0.8% of osteomyelitis cases. Salmonella infection also causes abscesses, including intra-abdominal infections, spontaneous peritonitis, splenic abscesses, and knee joint infections [3] Many non-typhoid Salmonella serovars, including S. Enteritidis, S. Typhimurium, S. Newport, S. Choleraesuis, S. Ohio, and S. Virchow, have been reported to Pathogens 2021, 10, 536 2 of 8 be the causal factor in osteomyelitis or septic arthritis in humans [4][5][6][7][8][9][10]. Fever and back pain were reported as the main symptoms for vertebral osteomyelitis caused by Salmonella infection [5].…”

“…A case report showed that S. Ohio caused septic arthritis and a bone abscess in a 44-year-old immunocompetent man in Japan, and the S. Ohio strain was isolated from his bone abscess and from joint tissue of his swollen left knee [6]. S. Newport was also reported to cause left knee pain in a 36-year-old man with a fever of 38 • C and new-onset diabetes, whereas the bacteria were isolated from his blood, pus, knee aspirate, and tibia tissue [7]. S. Montevideo was another rare Salmonella serovar, identified to induce septic arthritis of the knee in a 59-year-old woman who presented with a painful and swollen right knee associated with a fever of 38.8 • C [8].…”