Saccharopolyspora : an underexplored source for bioactive natural products

Abstract

Actinomycetes are a rich source for secondary metabolites with a diverse array of biological activities. Among the various genera of actinomycetes, the genus Saccharopolyspora has long been recognized as a potential source for antibiotics and other therapeutic leads that belong to diverse classes of natural products. Members of the genus Saccharopolyspora have been widely reported from several natural sources including both terrestrial and marine environments. A plethora of this genus has been chemically investigated for the production of novel natural products with interesting pharmacological effects. Therefore, Saccharopolyspora is considered one of the pharmaceutical important genera that could provide further chemical diversity with potential lead compounds. In this review, the literature from 1976 until December 2018 was covered, providing a comprehensive survey of all natural products derived from this genus and their semi-synthetic derivatives along with their biological activities, whenever applicable. Moreover, the biological diversity of Saccharopolyspora species and their habitats were also discussed.

Exploration of Chemical Diversity and Antitrypanosomal Activity of Some Red Sea-Derived Actinomycetes Using the OSMAC Approach Supported by LC-MS-Based Metabolomics and Molecular Modelling

“…The top-scoring compounds were determined depending on their docking scores and binding modes in comparison with the reported co-crystallized ligands (binding energy < −8 kcal/mol). As summarized in Figures 9 and 10, both trypanothione reductase (TR) and farnesyl diphosphate synthase (FDS) were found to be the most likely targets for nocardamine (2) and desferrioxamine B (3) and neihumicin (26), which achieved binding energy scores higher than the co-crystalized ligands (from −8.6 to −10.6 kcal/mol), while trichostatin A (16) achieved the highest binding score (−8.8 kcal/mol) against FDS only.…”

“…Actinomycetes are considered talented producers of bioactive secondary metabolites that are spread across a wide range of terrestrial and aquatic habitats. These Gram-positive bacteria can also establish symbiotic relationships with other higher organisms like plants, animals, and insects [1][2][3]. During the last 70 years, actinomycetes from terrestrial environments have been extensively investigated and have gained great success in providing much essential therapeutics (e.g., antibiotics and anticancer agents).…”

“…Induced metabolites(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) of Streptomyces sp. UR23-derived extracts: upon fermentation on the solid medium (black color, 1-4), on the liquid medium (blue color, 5-9), upon the co-fermentation on the solid medium (red color, 10-13), and upon the co-fermentation in the liquid medium (brown color, 14-18).…”

“…The most likely metabolites correlating with the observed antitrypanosomal activity of the active group of extracts according to OPLS-DA. Green color: metabolites (3, 10, 11) that showed high scores by PASS-based and docking-based virtual screenings; orange color: metabolites(2,16,26) that showed high scores by docking-base screening only; black color: metabolites(14,28,45) that did not show high scores upon any method of virtual screenings.…”

The genus Micromonospora as a model microorganism for bioactive natural product discovery

“…2 Actinobacteria represent one of the largest bacterial phyla which widespread across all natural habitats and clearly represented in both terrestrial and marine ecosystems 3,4 as well as extreme environments. 5 Approximately 70% of the naturallyderived compounds that are currently in the market or under clinical trials are derived from them. 6,7 The genus Micromonospora, a member of family Micromonosporaceae was originally proposed by Ørskov in 1923.…”