1992
DOI: 10.1016/0248-4900(92)90288-c
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Saccharomyces cerevisiae CDC25 [1028–1589] is a guanine nucleotide exchange factor for mammalian ras proteins and is ongenic in HIH3T3 cells

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Cited by 7 publications
(11 citation statements)
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“…The last 23 aa of Ras have been shown to be dispensable for binding, in agreement with the results reported here for the Rab3a-Mss4 interaction (24,25). However, a mutational analysis of Ras has shown that the switch II domain (which consists of L4/␣2), but not the switch I domain, is important for binding to its GEFs (26 -28).…”
Section: Discussionsupporting
confidence: 78%
“…The last 23 aa of Ras have been shown to be dispensable for binding, in agreement with the results reported here for the Rab3a-Mss4 interaction (24,25). However, a mutational analysis of Ras has shown that the switch II domain (which consists of L4/␣2), but not the switch I domain, is important for binding to its GEFs (26 -28).…”
Section: Discussionsupporting
confidence: 78%
“…3). To further characterize the consequences of membrane targeting for Ras GEF function, 'we evaluated the (24) and others (28) have shown that Ras GEFs can stimulate the activity of normal Ras to activate transcription from RREs. While transfection of 1 ug of pZIP-cCDC25 DNA caused limited stimulation of transcription activation from pB4X-CAT (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…We and others have shown that Ras GEFs can stimulate the activity of wild-type Ras to activate transcription from Ras-responsive promoter elements (8,43,44). To determine if FGD1 regulates transcriptional activation via direct stimulation of CDC42, we measured FGD1 activation of the Elk-1, Jun, and SRF reporters in the presence of wild-type CDC42.…”
Section: Fgd1mentioning
confidence: 99%