<i>Saccharomyces boulardii</i>stimulates sIgA production and the phagocytic system of gnotobiotic mice

Rodrigues, A.C.P.; Cara, Denise Carmona; Fretez, S.H.G.G.; Cunha, Fernando; Vieira, Eliane; Nicoli, Jacques R.; Vieira, Leda Quércia

doi:10.1046/j.1365-2672.2000.01128.x

Cited by 146 publications

(134 citation statements)

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“…However, since the results for C3H/HeJ mice are from pools of cells, no statistical analysis was performed. Macrophages from germ-free mice have been shown to be less reactive (and to produce less inflammatory cytokines) than macrophages from conventional mice in several different models (13,(37)(38)(39), a result consistent with the fact that macrophages from germ-free mice produced lower levels of IL-12 p40 when compared to monoassociated mice. However, macrophages from germ-free mice produced similar levels of TNF-α when stimulated with bacterial preparations.…”

Section: Discussionsupporting

confidence: 60%

Lactobacillus delbrueckii UFV-H2b20 induces type 1 cytokine production by mouse cells in vitro and in vivo

Neumann

Ramos

Santos

et al. 2009

Braz J Med Biol Res

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Lactobacillus delbrueckii UFV-H2b20 has been shown to increase clearance of bacteria injected into the blood of germ-free mice. Moreover, it induces the production of type 1 cytokines by human peripheral mononuclear cells. The objective of the present study was to investigate the production of inflammatory cytokines [interleukin-12 (IL-12 p40), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ)] triggered in vitro by live, heat-killed or lysozyme-treated L. delbrueckii UFV-H2b20 and in vivo by a live preparation. Germ-free, L. delbrueckii-monoassociated and lipopolysaccharide (LPS)-resistant C3H/HeJ mice were used as experimental models. UFV-H2b20 induced the production of IL-12 p40 and TNF-α by peritoneal cells and IFN-γ by spleen cells from germ-free or monoassociated Swiss/NIH mice and LPS-hyporesponsive mice (around 40 ng/mL for IL-12 p40, 200 pg/mL for TNF-α and 10 ng/mL for IFN-γ). Heat treatment of L. delbrueckii did not affect the production of these cytokines. Lysozyme treatment decreased IL-12 p40 production by peritoneal cells from C3H/HeJ mice, but did not affect TNF-α production by these cells or IFN-γ production by spleen cells from the same mouse strain. TNF-α production by peritoneal cells from Swiss/NIH L. delbrueckii-monoassociated mice was inhibited by lysozyme treatment. When testing IL-12 p40 and IFN-γ levels in sera from germ-free or monoassociated Swiss/NIH mice systemically challenged with Escherichia coli we observed that IL-12 p40 was produced at marginally higher levels by monoassociated mice than by germ-free mice (40 vs 60 ng/mL), but IFN-γ was produced earlier and at higher levels by monoassociated mice (monoassociated 4 and 14 ng/mL 4 and 8 h after infection, germfree 0 and 7.5 ng/mL at the same times). These results show that L. delbrueckii UFV-H2b20 stimulates the production of type 1 cytokines in vitro and in vivo, therefore suggesting that L. delbrueckii might have adjuvant properties in infection in which these cytokines play a major role.

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Section: Discussionsupporting

confidence: 60%

Lactobacillus delbrueckii UFV-H2b20 induces type 1 cytokine production by mouse cells in vitro and in vivo

Neumann

Ramos

Santos

et al. 2009

Braz J Med Biol Res

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“…During the intestinal transit, S. boulardii interacts with resident microflora and intestinal mucosa. Moreover, experimental studies suggest that S. boulardii is protective against enteric pathogens, modulating the host immune response, decreasing inflammation and hydro electrolytic secretions, inhibiting bacterial toxin and enhancing trophic factors such as brush border membrane enzymes and nutrient transporters (7,8,10,14,37,53,40,44,47) .…”

Section: Discussionmentioning

confidence: 99%

Treatment of Diarrhea-Predominant Irritable Bowel Syndrome With Mesalazine and/or Saccharomyces Boulardii

Boiocchi

Almeida

Leite

et al. 2013

Arq. Gastroenterol.

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-Results -Compared to baseline, there were statistically significant reduction of symptom score after 30 th day therapy in all three groups: MG (P<0.0001); MSbG (P<0.0001) and in SbG (P = 0.003). There were statistically significant differences in the symptom score at 30 th day therapy of the MG, MSbG and SbG groups (P = 0.03). There were no statistical differences between MSbG and MG symptom score at 30th day therapy (P = 0.9). Conclusions -The use of mesalazine alone, Saccharomyces boulardii alone or combined treatment with mesalasine and Saccaromyces boulardii improved IBS-D symptoms. The improvement of the symptom score was greater with mesalazine alone or combined with Sb as compared with Sb treatment alone. These preliminary results suggest that mezalazine may be useful in treatment of IBS-d patients, and warrant further larger studies. HEADINGS -Irritable bowel syndrome. Diarrhea. Mesalamine. Saccharomyces boulardii.

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“…A administração de probiótico elaborado com a levedura favoreceu a resposta imune celular tipos 1 e 2 estimulando a produção de IFN-γ e IL-4 em camundongos gnotobióticos (RODRIGUES et al, 2000). COPPOLA et al (2003) comprovaram que S. boulardii aumentou a resposta imune humoral de camundongos a uma bacterina de E. coli.…”

Section: Probióticos De Saccharomyces Boulardiiunclassified

Probióticos e resposta imune

Coppola

Gil-Turnes

2004

Cienc. Rural

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Saccharomyces boulardiistimulates sIgA production and the phagocytic system of gnotobiotic mice

Cited by 146 publications

References 58 publications

Lactobacillus delbrueckii UFV-H2b20 induces type 1 cytokine production by mouse cells in vitro and in vivo

Lactobacillus delbrueckii UFV-H2b20 induces type 1 cytokine production by mouse cells in vitro and in vivo

Treatment of Diarrhea-Predominant Irritable Bowel Syndrome With Mesalazine and/or Saccharomyces Boulardii

Probióticos e resposta imune

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