<i>S100A3</i> mRNA expression displays an inverse correlation to breast cancer progression

Lloyd, Bryony H.; Ruddell, Carolyn J.; Rudland, Philip S.; Barraclough, Roger

doi:10.1042/bst024340s

Cited by 10 publications

(9 citation statements)

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“…We and others also identified psoriasin as one of the few genes that is highly and more frequently expressed in ductal carcinoma in situ (DCIS) than in invasive breast carcinomas, suggesting a potential role in tumor progression (3,(6)(7)(8)(9). Other members of the S100 gene family have also been shown to be associated with breast tumor progression; most notably, S100A4 has been implicated in promoting cell invasion and metastasis, and correlating with this, its expression is associated with worse outcome in breast cancer (10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

A Putative Role for Psoriasin in Breast Tumor Progression

et al. 2005

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Psoriasin (S100A7) was identifi'ed as a gene highly expressed in psoriatic keratinocytes and highly and more frequently expressed in ductal carcinoma in situ (DCIS) than in invasive breast carcinomas (IBC), suggesting a potential role in tumor progression. Psoriasin expression is associated with poor prognostic factors in both DCIS and IBC. Several putative functions have been proposed for psoriasin in various disease types, but none of these can fully explain its involvement in breast tumor progression. Here, we show that downregulation of endogenous psoriasin expression via stable short hairpin RNAs in a human IBC cell line (MDA-MB-468) increases cell migration and invasion without influencing cell proliferation and survival in vitro but inhibits tumor growth in vivo. These seemingly paradoxical results are potentially explained by the dramatic up-regulation and down-regulation of matrix metalloproteinase-13 and vascular endothelial growth factor (VEGF), respectively, observed in cells with decreased psoriasin levels compared with controls. Correlating with this, high psoriasin expression in human IBC is associated with increased angiogenesis and worse clinical outcome, and psoriasin mRNA levels are coordinately regulated with VEGF and other genes related to hypoxia and mitochondrial reactive oxygen species (ROS). Based on these results, we propose that psoriasin may play a role in breast tumor progression by promoting angiogenesis and enhancing the selection for cells that overcome its anti-invasive function. This hypothesis may explain why psoriasin expression is highest in high-grade and/or estrogen receptor-negative tumors, as these are associated with increased hypoxia and ROS, a setting in which the angiogenic effects of psoriasin are most important. (Cancer Res 2005; 65(24): 11326-34)

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Section: Introductionmentioning

confidence: 99%

A Putative Role for Psoriasin in Breast Tumor Progression

et al. 2005

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“…There is no information regarding function or physiologic properties of the S100A3 protein available. One study reports that the S100A3 mRNA expression is inversely correlated to breast cancer progression (12), and one study show that the expression of S100A3 protein is increased in anaplastic astrocytomas compared to low-grade astrocytomas (13). S100A4, however, is known to induce metastatic phenotype in otherwise non-metastatic tumor cells, correlate to metastatic disease and worse prognosis in several tumor forms and seem to be involved in cell motility, as well as specific phosphorylation events in the cell, acting through PKCs (14).…”

Section: Discussionmentioning

confidence: 98%

Differentially Expressed cDNAs in PLCβ3-Induced Tumor Suppression in a Human Endocrine Pancreatic Tumor Cell Line: Activation of the Human Mismatch Repair Protein 3 Gene

Stålberg

Lopez-Egido

Wang

et al. 2001

Biochemical and Biophysical Research Communications

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“…Therefore, they participate in the immune response, cell migration and chemotaxis, tissue repair, and tumor cell invasion (Donato et al, 2013). S100A3 is overexpressed in head and neck cancer, colorectal cancer, bladder cancer, gastric cancer, and astrocytic tumors, but has an inverse correlation to breast cancer progression (Lloyd et al, 1996;Camby et al, 2000;Yao et al, 2007;Liu et al, 2008Liu et al, , 2013Tyszkiewicz et al, 2014). It is also highly expressed in hair root cells, and is thought to have a role in epithelial cell differentiation and Ca 2+ -dependent hair cuticular barrier formation (Kizawa et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…It is specifically expressed in cuticular cells, and to a lesser extent in the cortical cells of hair follicles in humans (Kizawa et al, 1996;Takizawa et al, 1999), mice (Kizawa et al, 1998), and rats (Kizawa and Ito, 2005). In addition, S100A3 is expressed in head and neck cancer (Tyszkiewicz et al, 2014), breast cancer (Lloyd et al, 1996), gastric cancer (Liu et al, 2008), colorectal cancer (Liu et al, 2013), bladder cancer (Yao et al, 2007), and astrocytic tumors (Camby et al, 2000). Because these cell types are characterized by high proliferation rates, S100A3 is thought to be involved in cell cycle progression.…”

Section: Introductionmentioning

confidence: 99%

Blockade of S100A3 activity inhibits murine hair growth

Guan¹,

Deng²,

Yu³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Using mouse gene expression microarray analysis, we obtained dynamic expression profiles of the whole genome in a depilationinduced hair growth mouse model. S100A3 expression increased during the anagen phase and returned to normal during the telogen phase. The effects of S100A3 blockade on the hair growth cycle were examined in mice after subcutaneous injection of an anti-mouse S100A3 antibody. Protein localization of S100A3 was confined to the hair shafts during the anagen phase and the sebaceous glands during the telogen phase. S100A3 blockade delayed hair follicle entry into the anagen phase, decreased hair elongation, and reduced the number of hair follicles in the subcutis, which correlated with the downregulated expression of hair growth inductionrelated genes in vivo. The present study demonstrates that anti-S100A3 antibody inhibits mouse hair growth, suggesting that S100A3 can be used as a target for hair loss treatment.

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S100A3 mRNA expression displays an inverse correlation to breast cancer progression

Cited by 10 publications

References 0 publications

A Putative Role for Psoriasin in Breast Tumor Progression

A Putative Role for Psoriasin in Breast Tumor Progression

Differentially Expressed cDNAs in PLCβ3-Induced Tumor Suppression in a Human Endocrine Pancreatic Tumor Cell Line: Activation of the Human Mismatch Repair Protein 3 Gene

Blockade of S100A3 activity inhibits murine hair growth

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