I.S.Mu.L.T - Rotator Cuff Tears Guidelines

Oliva, Francesco; Piccirilli, Eleonora; Bossa, M.; VIa, Arion; Colombo, A; Chillemi, Claudio; Gasparre, Giuseppe; Pellicciari, Leonardo; Franceschetti, Edoardo; Rugiero, Clelia; Scialdoni, Alessandro; Vittadini, Filippo; Brancaccio, Paola; Creta, Domenico; Buono, Angelo Del; Garofalo, Raffaele; Franceschi, Francesco; Frizziero, Antonio; Mahmoud, Ahmed Abdelaal Ahmed; Merolla, Giovanni; Nicoletti, S.; Spoliti, Marco; Osti, Leonardo; Padulo, Johnny; Portinaro, Nicola; Tajana, G; Castagna, Alessandro; Foti, Calogero; Masiero, Stefano; Porcellini, Giuseppe; Tarantino, Umberto; Maffulli, Nicola

doi:10.32098/mltj.04.2015.01

Cited by 52 publications

(8 citation statements)

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“…Supraspinatus tendon (ST) tear is a widespread disorder characterized by functional deficits in the shoulder such as weakness, decreased range of motion, and debilitating pain . Mesenchymal stem cell (MSC) therapy provides a unique opportunity for redirecting the healing process away from scar formation and toward the regeneration of a fibrocartilaginous tendon‐bone insertion (enthesis) .…”

Section: Introductionmentioning

confidence: 94%

Visualizing the Fate of Intra‐Articular Injected Mesenchymal Stem Cells In Vivo in the Second Near‐Infrared Window for the Effective Treatment of Supraspinatus Tendon Tears

et al. 2019

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Mesenchymal stem cells (MSCs) are capable of exerting strong therapeutic potential for the treatment of supraspinatus tendon tear. However, MSC therapy remains underutilized and perhaps underrated due to the limited evidence of dynamic visualization of cellular behavior in vivo. Here, second near‐infrared fluorescence imaging with biocompatible PbS quantum dots (QDs) provides a cellular migration map and information on the biodistribution and clearance processes of three densities of intra‐articularly injected, labeled MSCs to treat supraspinatus tendon tear in mice. Intra‐articular injection avoids entrapment of MSCs by filter organs and reduces the QD‐induced organ toxicity. Notably, the MSCs share a similar migration direction, but the moderate density group is somewhat more efficient, showing the longest residence time and highest cell retention rate around the footprint during the repair stage. Furthermore, quantitative kinetic investigation demonstrates that labeled MSCs are cleared by feces and urine. Histomorphometric analysis demonstrates that the moderate density group achieves maximum therapeutic effect and labeled MSCs do not induce any injury or inflammation to major organs, which suggests that administration of too many or few MSCs may decrease their effectiveness. Such an imaging approach provides spatiotemporal evidence for response to MSC therapy in vivo, facilitating the optimization of MSC therapy.

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Section: Introductionmentioning

confidence: 94%

Visualizing the Fate of Intra‐Articular Injected Mesenchymal Stem Cells In Vivo in the Second Near‐Infrared Window for the Effective Treatment of Supraspinatus Tendon Tears

et al. 2019

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“…PRP, glucocorticoids, local anaesthetics, or hyaluronic acid are used to reduce pain and improve performance in patients who undergo rotator cuff repair. Among them, local anaesthetics and glucocorticoids have cytotoxic effects on tenocytes, and hyaluronic acid decreases pain in patients with partial tear of the rotator cuff tendons [8]. Recently, many authors have reported the effects of PRP on partial or complete tears of rotator cuff tendons [9–11].…”

Section: Introductionmentioning

confidence: 99%

Is platelet-rich plasma an ideal biomaterial for arthroscopic rotator cuff repair? A systematic review and meta-analysis of randomized controlled trials

Han

Zhu

et al. 2019

J Orthop Surg Res

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Background Recently, many authors have reported the effects of platelet-rich plasma (PRP) on rotator cuff repair. Whether PRP treatment during arthroscopic rotator cuff repair improves tendon healing rates or restores full function remains unknown. The purpose of this meta-analysis was to evaluate the clinical improvement and radiological outcomes of PRP treatment in patients undergoing arthroscopic rotator cuff repair. Methods PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched. The study included only level 1 or 2 randomized controlled trials (RCTs) that compared the injection of platelet-rich plasma or platelet-rich fibrin matrix. The methodological quality of the trials was assessed using the Cochrane Handbook for Systematic Reviews of Interventions, 5.3. Continuous variables were analysed using the weighted mean difference, and categorical variables were assessed using relative risks. P < 0.05 was considered statistically significant. Results The meta-analysis revealed a lower retear rate following PRP treatment than that following the control method (mean difference, 1.10; 95% CI, 1.03 to 1.18; P = 0.004). Constant shoulder scores improved with PRP (mean difference, 2.31; 95% CI, 1.02 to 3.61; P = 0.0005). PRP treatment also resulted in higher UCLA scores (mean difference, 0.98; 95% CI, 0.27 to 1.69; P = 0.007), and simple shoulder test scores were improved (mean difference, 0.43; 95% CI, 0.11 to 0.75; P = 0.008). Finally, lower visual analogue scale scores were observed with PRP augmentation (mean difference, − 0.35; 95% CI, − 0.57 to − 0.13; P = 0.002). Conclusions The current systematic review and meta-analysis reveals that PRP treatment with arthroscopic repair of rotator cuff tears decreases the retear rate and improves the clinical outcomes. Systematic review registration PROSPERO CRD42016048416

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“…A PROM commonly used to evaluate upper extremity function is the Disabilities of Arm, Shoulder, and Hand questionnaire (DASH) [11] . The DASH can detect and differentiate small and large changes in disability over time after surgery in patients with a variety of upper-extremity musculoskeletal disorders [12–14] .…”

Section: Introductionmentioning

confidence: 99%

Translation and validation of a Hebrew version of the Western Ontario Shoulder Instability index

Gottlieb

Springer

2019

J Orthop Surg Res

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Background The Western Ontario Shoulder Instability index (WOSI) is a questionnaire designed to measure health-related quality of life in patients with shoulder instability. The aim of the current study was to translate the WOSI into Hebrew and assess its psychometric properties. Methods The WOSI was translated into Hebrew according to World Health Organization guidelines. Twenty-five patients completed the WOSI and the Disabilities of Arm, Shoulder, and Hand (DASH) questionnaire 2 weeks and 2 months after surgical shoulder stabilization. Internal consistency (Cronbach’s α), criterion validity (Pearson’s correlation coefficient with DASH), responsiveness, and floor and ceiling effects were assessed. Results Cronbach’s α was 0.88–0.95 for total WOSI (range 0.68–0.95 for different sections). Strong correlation with DASH score ( r = 0.76–0.84) indicated good criterion validity. Changes between baseline and follow-up for WOSI and DASH scores were moderately correlated ( r = 0.68), suggesting moderate responsiveness. Some items demonstrated floor and ceiling effects, especially at baseline, but no floor or ceiling effects were observed for total WOSI or for the WOSI sections. Conclusions The results of the current study demonstrate that the Hebrew version of the WOSI is a valid instrument that can be used to assess disability in patients with shoulder instability. Additional studies are warranted to assess its psychometric properties among various subpopulations. Trial registration The study was pre-registered at the ClinicalTrials.gov website, registration number NCT02978365 .

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I.S.Mu.L.T - Rotator Cuff Tears Guidelines

Cited by 52 publications

References 0 publications

Visualizing the Fate of Intra‐Articular Injected Mesenchymal Stem Cells In Vivo in the Second Near‐Infrared Window for the Effective Treatment of Supraspinatus Tendon Tears

Visualizing the Fate of Intra‐Articular Injected Mesenchymal Stem Cells In Vivo in the Second Near‐Infrared Window for the Effective Treatment of Supraspinatus Tendon Tears

Is platelet-rich plasma an ideal biomaterial for arthroscopic rotator cuff repair? A systematic review and meta-analysis of randomized controlled trials

Translation and validation of a Hebrew version of the Western Ontario Shoulder Instability index

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