<i>Roseburia</i>
            Spp.: A Marker of Health?

Tamanai-Shacoori, Zohreh; Smida, Imen; Bousarghin, Latifa; Loréal, Olivier; Meuric, Vincent; Fong, Shao Bing; Bonnaure‐Mallet, Martine; Jolivet‐Gougeon, Anne

doi:10.2217/fmb-2016-0130

Cited by 492 publications

(411 citation statements)

References 118 publications

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“…Roseburia spp. , commensal bacteria that have been demonstrated to produce short‐chain fatty acids, and alteration in their abundance might affect numerous metabolic diseases , as they were less in postmenopausal women than in premenopausal women, which might be correlated with change of metabolism.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, Eubacterium eligens was reported to have reduced abundance in postmenopausal women with breast cancer [16], and a higher abundance in the Eubacterium rectale cluster stimulated by isoflavones had the ability to prevent women from developing menopause syndrome [33]. Roseburia spp., commensal bacteria that have been demonstrated to produce short-chain fatty acids, and alteration in their abundance might affect numerous metabolic diseases [34], as they were less in postmenopausal women than in premenopausal women, which might be correlated with change of metabolism.…”

Section: B a C T E R O I D E T E S F I R M I C U T E S P R O T E O B mentioning

confidence: 99%

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Compositional and functional features of the female premenopausal and postmenopausal gut microbiota

Zhao

Chen

et al. 2019

FEBS Letters

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Endogenous estrogen deficiency accelerates many diseases in postmenopausal women, and gut microbes contribute to estrogen level modulation. However, the compositional alterations and influences of the gut microbiota in postmenopausal women remain uncertain. A metagenome‐wide association study was performed to compare the gut microbiota of 24 premenopausal and 24 postmenopausal women. Firmicutes and Roseburia spp. are depleted, while Bacteroidetes and the toluene‐producing genus Tolumonas are overrepresented in fecal samples from postmenopausal women. The pentose phosphate pathway is enriched in premenopausal women. Homocysteine synthesis‐related processes are enriched in postmenopausal women. The gut microbiomes of premenopausal and postmenopausal women differ and produce different metabolites. The gut microbiome may be a therapeutic target to reduce risks and improve the quality of life in postmenopausal women.

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Section: Resultsmentioning

confidence: 99%

Section: B a C T E R O I D E T E S F I R M I C U T E S P R O T E O B mentioning

confidence: 99%

Compositional and functional features of the female premenopausal and postmenopausal gut microbiota

Zhao

Chen

et al. 2019

FEBS Letters

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“…Indeed, it has been shown both in humans and in mice that probiotic supplementation with lactobacilli and bifidobacteria, by stimulating a cross-feeding mechanism, increases Roseburia abundance and butyrate production [68]. Moreover, pre- and probiotic administration could represent a feasible intervention for AN patients because of its extremely low calories or calorie-free content, improving recovery rates.…”

Section: Discussionmentioning

confidence: 99%

Microbiota in anorexia nervosa: The triangle between bacterial species, metabolites and psychological tests

Borgo

Riva

Benetti³

et al. 2017

PLoS ONE

201

248

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Anorexia nervosa (AN) is a psychiatric disease with devastating physical consequences, with a pathophysiological mechanism still to be elucidated. Metagenomic studies on anorexia nervosa have revealed profound gut microbiome perturbations as a possible environmental factor involved in the disease. In this study we performed a comprehensive analysis integrating data on gut microbiota with clinical, anthropometric and psychological traits to gain new insight in the pathophysiology of AN. Fifteen AN women were compared with fifteen age-, sex- and ethnicity-matched healthy controls. AN diet was characterized by a significant lower energy intake, but macronutrient analysis highlighted a restriction only in fats and carbohydrates consumption. Next generation sequencing showed that AN intestinal microbiota was significantly affected at every taxonomic level, showing a significant increase of Enterobacteriaceae, and of the archeon Methanobrevibacter smithii compared with healthy controls. On the contrary, the genera Roseburia, Ruminococcus and Clostridium, were depleted, in line with the observed reduction in AN of total short chain fatty acids, butyrate, and propionate. Butyrate concentrations inversely correlated with anxiety levels, whereas propionate directly correlated with insulin levels and with the relative abundance of Roseburia inulinivorans, a known propionate producer. BMI represented the best predictive value for gut dysbiosis and metabolic alterations, showing a negative correlation with Bacteroides uniformis (microbiota), with alanine aminotransferase (liver function), and with psychopathological scores (obsession-compulsion, anxiety, and depression), and a positive correlation with white blood cells count. In conclusion, our findings corroborate the hypothesis that the gut dysbiosis could take part in the AN neurobiology, in particular in sustaining the persistence of alterations that eventually result in relapses after renourishment and psychological therapy, but causality still needs to be proven.

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“…Of the 30 species enriched in controls (Figure 5) and identified only by metagenomics, three were particularly associated with a beneficial effect for the host in the literature (Takagaki and Nanjo, 2015; Ze et al, 2015; Tamanai-Shacoori et al, 2017). These three species namely Roseburia intestinalis, Ruminococcus broomii , and Adlercreutzia equolifaciens can also be beneficial in the restoration of a healthy flora, short chain fatty acid production, and antioxidants metabolism.…”

Section: Discussionmentioning

confidence: 99%

Gut Bacteria Missing in Severe Acute Malnutrition, Can We Identify Potential Probiotics by Culturomics?

et al. 2017

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Severe acute malnutrition is the world-leading cause of children under-five's death. Recent metagenomics studies have established a link between gut microbiota and severe acute malnutrition, describing an immaturity with a striking depletion in oxygen-sensitive prokaryotes. Amoxicillin and therapeutic diet cure most of the children with severe acute malnutrition but an irreversible disruption of the gut microbiota is suspected in the refractory and most severe cases. In these cases, therapeutic diet may be unable to reverse the microbiota alteration leading to persistent impaired development or death. In addition, as enteric sepsis is a major cause of death in this context, identification of missing gut microbes to be tested as probiotics (live bacteria that confer a benefit to the host) to restore rapidly the healthy gut microbiota and prevent the gut pathogenic invasion is of foremost importance. In this study, stool samples of malnourished patients with kwashiorkor and healthy children were collected from Niger and Senegal and analyzed by culturomics and metagenomics. We found a globally decreased diversity, a decrease in the hitherto unknown diversity (new species isolation), a depletion in oxygen-sensitive prokaryotes including Methanobrevibacter smithii and an enrichment in potentially pathogenic Proteobacteria, Fusobacteria and Streptococcus gallolyticus. A complex of 12 species identified only in healthy children using culturomics and metagenomics were identified as probiotics candidates, providing a possible, defined, reproducible, safe, and convenient alternative to fecal transplantation to restore a healthy gut microbiota in malnourished children. Microbiotherapy based on selected strains has the potential to improve the current treatment of severe acute malnutrition and prevent relapse and death by reestablishing a healthy gut microbiota.

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Roseburia Spp.: A Marker of Health?

Cited by 492 publications

References 118 publications

Compositional and functional features of the female premenopausal and postmenopausal gut microbiota

Compositional and functional features of the female premenopausal and postmenopausal gut microbiota

Microbiota in anorexia nervosa: The triangle between bacterial species, metabolites and psychological tests

Gut Bacteria Missing in Severe Acute Malnutrition, Can We Identify Potential Probiotics by Culturomics?

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