<i>Rickettsia slovaca</i>Infection in Humans, Portugal

Sousa, Rita de; Pereira, Branca; Nazareth, Cláudia; Cabral, Susana; Ventura, Conceição; Crespo, Pedro Ochoa; Marques, Nuno; Cunha, Saraiva da

doi:10.3201/eid1910.130376

Cited by 30 publications

(27 citation statements)

References 12 publications

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“…In the period of the present series, some cases of less common Rickettsiosis have been described by our unit (Pereira et al 2011; Sousa et al 2013). …”

Section: Discussionmentioning

confidence: 57%

Mediterranean spotted fever: case series of 24 years (1989–2012)

et al. 2015

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PurposeMediterranean spotted fever (MSF) is the most prevalent zoonosis in Portugal. To characterize it’s evolution between 1989 and 2012, the authors reviewed the cases diagnosed at their unit during this period.MethodsReview of clinical records of patients with MSF diagnosis, between 1989 and 2012.ResultsData from 250 patients was included, 54% male. Mean age at diagnosis was 58 years (11–92). Mean annual incidence was 10 cases, with clear summer predominance. Most patients, 78% lived in rural areas, 34% had contact with dogs and 10% noticed the tick bite. Most common symptoms were: fever (98%), myo-arthralgia (64%) and headache (48%). Maculopapular rash was noticed in 87%, affecting palms in 77% and soles in 69%. Inoculation eschar was found in 60%, mostly located on the trunk. Treatment included doxycycline in 86% and chloramphenicol in 12%, with a mean duration of 8 days. Most frequent blood test abnormalities were C-reactive protein, lactate dehydrogenase, aspartate aminotransferase and alanine transaminase elevations and thrombocytopenia. First serologic evaluation was positive in 37% (78/212), having seroconversion been documented in 85% (72/85). Most frequent complication was acute renal injury. ICU admission occurred in 5%. Average length of hospital stay was 11.2 days (1–106), with a mortality of 3.6%.ConclusionsIn our series, there was clear summer predominance of MSF, which had rural origin in 78%. Most common symptoms were fever, myo-arthralgia and headache. Maculopapular rash was noticed in 87% of cases and inoculation eschar in 60%. Most cases had favourable outcome, having 5% been admitted to ICU. Mortality was 3.6%.Electronic supplementary materialThe online version of this article (doi:10.1186/s40064-015-1042-3) contains supplementary material, which is available to authorized users.

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“…In the period of the present series, some cases of less common Rickettsiosis have been described by our unit (Pereira et al 2011; Sousa et al 2013). …”

Section: Discussionmentioning

confidence: 57%

Mediterranean spotted fever: case series of 24 years (1989–2012)

et al. 2015

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“…135 Notably, a third of patients develop persistent alopecia where the eschar was present. 135 DEBONEL/TIBOLA/ SENLAT is currently the second most prevalent tick-borne rickettsiosis in Europe after that caused by R. conorii, 50 with human cases reported in France, Spain, Hungary, Slovakia, Bulgaria, Italy, Germany, and Portugal, 50,[136][137][138][139] where it tends to affect mainly women and children. 132,135 A case of this syndrome caused by R. massiliae reported in Italy has recently been published.…”

Section: Associated With Regional Lymphadenopathymentioning

confidence: 99%

Syndromic classification of rickettsioses: an approach for clinical practice

Faccini-Martínez

García‐Álvarez

Hidalgo

et al. 2014

International Journal of Infectious Diseases

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Rickettsioses share common clinical manifestations, such as fever, malaise, exanthema, the presence or absence of an inoculation eschar, and lymphadenopathy. Some of these manifestations can be suggestive of certain species of Rickettsia infection. Nevertheless none of these manifestations are pathognomonic, and direct diagnostic methods to confirm the involved species are always required. A syndrome is a set of signs and symptoms that characterizes a disease with many etiologies or causes. This situation is applicable to rickettsioses, where different species can cause similar clinical presentations. We propose a syndromic classification for these diseases: exanthematic rickettsiosis syndrome with a low probability of inoculation eschar and rickettsiosis syndrome with a probability of inoculation eschar and their variants. In doing so, we take into account the clinical manifestations, the geographic origin, and the possible vector involved, in order to provide a guide for physicians of the most probable etiological agent.

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“…The first proven human case of R . slovaca infection was reported in 1997 in continental France and this micro-organism is now known as a cause of disease in various European Mediterranean countries (de Sousa et al, 2013). It is associated with TIBOLA (tickborne lymphadenopathy) syndrome, characterized by lymph node enlargement and scalp eschars (Parola et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Tick-borne pathogens in ticks (Acari: Ixodidae) collected from various domestic and wild hosts in Corsica (France), a Mediterranean island environment

Grech‐Angelini

Stachurski

Vayssier‐Taussat

et al. 2019

Preprint

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2 0 2 1 2 2 2 ABSTRACT 2 3Corsica is a touristic mountainous French island in the north-west of the Mediterranean Sea presenting 2 4 a large diversity of natural environments where many interactions between humans, domestic animals 2 5 and wild fauna occur. Despite this favourable context, tick-borne pathogens (TBPs) have not 2 6 systematically been investigated. In this study, a large number of TBPs were screened in ticks 2 7 collected during one year from domestic and wild hosts in Corsica. More than 1,500 ticks belonging 2 8 to nine species and five genera (Rhipicephalus, Hyalomma, Dermacentor, Ixodes and Haemaphysalis) 2 9were analysed individually or pooled (by species, gender, host and locality). A real-time microfluidic 3 0 PCR was used for high-throughput screening of TBPs DNA. This advanced methodology permitted 3 1 the simultaneous detection of 29 bacterial and 12 parasitic species (including Borrelia, Anaplasma,

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Rickettsia slovacaInfection in Humans, Portugal

Cited by 30 publications

References 12 publications

Mediterranean spotted fever: case series of 24 years (1989–2012)

Mediterranean spotted fever: case series of 24 years (1989–2012)

Syndromic classification of rickettsioses: an approach for clinical practice

Tick-borne pathogens in ticks (Acari: Ixodidae) collected from various domestic and wild hosts in Corsica (France), a Mediterranean island environment

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