Rhinacanthus nasutusImproves the Levels of Liver Carbohydrate, Protein, Glycogen, and Liver Markers in Streptozotocin-Induced Diabetic Rats

Abstract

The present study was designed to investigate the total carbohydrate, total protein, and glycogen levels in the liver and to measure functional liver markers such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in streptozotocin-(STZ-) induced diabetic rats after treatment with methanolic extract of Rhinacanthus nasutus (R. nasutus). The methanolic extract of R. nasutus was orally administered at 200 mg/kg/day while glibenclamide was administered at 50 mg/kg/day. All animals were treated for 30 days before being sacrificed. The amounts of carbohydrate, glycogen, proteins, and liver markers (AST and ALT) were measured in the liver tissue of the experimental animals. The levels of carbohydrate, glycogen, and proteins were significantly reduced in the diabetic rats but were augmented considerably after 30 days of R. nasutus treatment. The elevated AST and ALT levels in diabetic rats showed a significant decline after treatment with R. nasutus for 30 days. These results show that the administration of R. nasutus ameliorates the altered levels of carbohydrate, glycogen, proteins, and AST and ALT observed in diabetic rats and indicate that R. nasutus restores overall metabolism and liver function in experimental diabetic rats. In conclusion, the outcomes of the present study support the traditional belief that R. nasutus could ameliorate the diabetic state.

Four‐Week Consumption of Malaysian Honey Reduces Excess Weight Gain and Improves Obesity‐Related Parameters in High Fat Diet Induced Obese Rats

“…Meanwhile, the biochemical indices such as enzymes found in the liver and kidneys are useful markers for assessment of tissue damage [ 39 ]. Tissue enzymes can also indicate tissue cellular damage caused by chemical compounds before structural damage that can be detected by conventional histological techniques [ 40 ]. The observation showed that liver enzymes such as ALP, AST, and ALT were significantly higher in HFD and HFDO groups ( Table 4 ).…”

Anti-herpes simplex virus type 2 activity from Rhinacanthus nasutus (Linn.) Kurz. extracts as affected by different extraction solvents

“…In previous reports, methanol was reported as a suitable solvent for isolating the active components from R. nasutus (Rao et al, 2013). Brimson et al (2011) has shown that the root extract of R. nasutus prevented the hyotoxic conditions from HT-22 cell death by reducing the production of reactive oxygen species (ROS).…”

Antihyperglycemic and Antihyperlipidemic Activity of HydroponicStevia rebaudianaAqueous Extract in Hyperglycemia Induced by Immobilization Stress in Rabbits

“…It is known that hyperglycemia is commonly associated with disturbance of lipid metabolism, leading to the increased TC and low-density lipoprotein as well as decreased high-density lipoprotein levels [6, 29–32]. The elevated levels of TC and LDL could be risk factors for cardiovascular disease; conversely, the increased HDL levels, which play a key role in cholesterol transport from the periphery to the liver, reduce the risk of cardiovascular disease [6, 32].…”